Title:
FAT EMULSION
Document Type and Number:
WIPO Patent Application WO/1991/010431
Kind Code:
A1
Abstract:
A fat emulsion mainly comprising 0.001 to 10 % (w/v) of a mitomycin C derivative of general formula (I), 0.5 to 30 % (w/v) of a simple lipid, a phospholipid in an amount of 0.05 to 2 times by weight as large as the simple lipid, and an appropriate amount of water: (I) wherein X represents -(CH2)n-O- or -(CH2)n-NHCOO-; n represents an integer of 0 to 4; and R represents a linear or branched, open-chain or cyclic, saturated or unsaturated hydrocarbon group containing 3 to 25 carbon atomes. This emulsion causes efficient migration of a prodrug of mitomycin C with a carcinostatic action in the form of an injection into the tissues, helps to maintain its blood level, and allows safe administration of an effective dose.
Inventors:
Seki
Junzo, Ushimaru
Kouichi, Sugiyama
Makoto
Junzo, Ushimaru
Kouichi, Sugiyama
Makoto
Application Number:
PCT/JP1991/000006
Publication Date:
July 25, 1991
Filing Date:
January 09, 1991
Export Citation:
Assignee:
Nippon
Shinyaku
Ltd CO.
Shinyaku
Ltd CO.
International Classes:
A61K9/107; A61K31/40; (IPC1-7): A61K9/107; A61K9/127; A61K9/14; A61K31/40
Previous Patent: ESTERS OF 2-ARYLMETHYL-1-NAPHTHOL DERIVATIVES AS 5-LIPOXYGENASE INHIBITORS
Next Patent: ATARACTIC
Next Patent: ATARACTIC