Title:
FBLN5 GENE-DEFICIENT ANIMAL MODEL, AND METHOD FOR SCREENING NERVE OR MUSCLE DISORDER THERAPEUTIC AGENTS USING SAME
Document Type and Number:
WIPO Patent Application WO/2020/091235
Kind Code:
A1
Abstract:
The present invention pertains to: an Fbln5 (Fibulin-5) gene-deficient animal model; a method for screening nerve or muscle disorder therapeutic agents using the animal model; and a pharmaceutical composition containing a nerve or muscle disorder therapeutic agent screened using the method. When the animal model of the present invention is used, demyelinating disease therapeutic agents having good efficacy and few side-effects can be effectively screened, and drug candidate materials can be easily and quickly tested for in vivo side-effects due to the toxicity thereof. Moreover, substances screened by Fbln5 proteins and the zebrafish model of the present invention can be usefully used to alleviate, treat, or prevent nerve or muscle disorders.
Inventors:
LEE JI EUN (KR)
CHANG JONG WOOK (KR)
WON SO YEON (KR)
CHANG JONG WOOK (KR)
WON SO YEON (KR)
Application Number:
PCT/KR2019/012636
Publication Date:
May 07, 2020
Filing Date:
September 27, 2019
Export Citation:
Assignee:
SAMSUNG LIFE PUBLIC WELFARE FOUNDATION (KR)
UNIV SUNGKYUNKWAN RES BUSINESS FOUND (KR)
UNIV SUNGKYUNKWAN RES BUSINESS FOUND (KR)
International Classes:
A01K67/027; C07K14/46; G01N33/50
Foreign References:
| US20170071972A1 | 2017-03-16 | |||
| JP2006204110A | 2006-08-10 |
Other References:
NAKAMURA, T.: "Fibulin-5/DANCE is essential for elastogenesis in vivo", NATURE, 10 January 2002 (2002-01-10), XP002998232
YANAGISAWA, H. ET AL.: "Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo", NATURE, 10 January 2002 (2002-01-10), pages 168 - 171, XP002998230, DOI: 10.1038/415168a
AUER-GRUMBACH, M.: "Fibulin-5 mutations link inherited neuropathies, age-related macular degeneration and hyperelastic skin", BRAIN, vol. 18, June 2011 (2011-06-01), pages 39 - 1852, XP55704427
YANAGISAWA, H. ET AL.: "Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo", NATURE, 10 January 2002 (2002-01-10), pages 168 - 171, XP002998230, DOI: 10.1038/415168a
AUER-GRUMBACH, M.: "Fibulin-5 mutations link inherited neuropathies, age-related macular degeneration and hyperelastic skin", BRAIN, vol. 18, June 2011 (2011-06-01), pages 39 - 1852, XP55704427
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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