Title:
Fc-FUSED HIGH AFFINITY IgE RECEPTOR α-CHAIN
Document Type and Number:
WIPO Patent Application WO/2016/133197
Kind Code:
A1
Abstract:
Provided is an Fc-fused high affinity IgE receptor α-chain having excellent stability at low pH. An Fc fusion protein characterized by comprising (i) a high affinity IgE receptor α-chain and (ii) a Fc region of IgG1, wherein the linker fragment region between (i) and (ii) has the amino acid sequence of SEQ ID NO. 2.
Inventors:
SAKAMOTO TAKASHI (JP)
INADA YOICHI (JP)
YOKOYAMA KAZUMASA (JP)
INADA YOICHI (JP)
YOKOYAMA KAZUMASA (JP)
Application Number:
PCT/JP2016/054854
Publication Date:
August 25, 2016
Filing Date:
February 19, 2016
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
International Classes:
C07K19/00; A61K38/16; A61P11/02; A61P11/06; A61P27/02; A61P37/08; C07K14/705; C07K16/18; C12N15/09
Domestic Patent References:
| WO2013124451A1 | 2013-08-29 | |||
| WO2013124450A1 | 2013-08-29 |
Foreign References:
| JP2005511707A | 2005-04-28 | |||
| JP2013520176A | 2013-06-06 | |||
| JP2013538052A | 2013-10-10 |
Other References:
HAAK-FRENDSCHO M. ET AL.: "Human IgE receptor alpha-chain IgG chimera blocks passive cutaneous anaphylaxis reaction in vivo", J. IMMUNOL., vol. 151, 1993, pages 351 - 358, XP000942183
See also references of EP 3260469A4
See also references of EP 3260469A4
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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