Title:
FCGAMMARIIB POLYMORPHISMS DETECTION IN SYSTEM LUPUS ERYTHEMATOSUS
Document Type and Number:
WIPO Patent Application WO2003072828
Kind Code:
A3
Abstract:
The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding FcgammaRIIB. The invention also provides isolated nucleic acids encoding FcgammaRIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.
Inventors:
PRICOP LUMINITA (US)
Application Number:
PCT/US2003/004111
Publication Date:
November 27, 2003
Filing Date:
February 11, 2003
Export Citation:
Assignee:
NEW YORK SOC FOR THE RUPTURED (US)
PRICOP LUMINITA (US)
PRICOP LUMINITA (US)
International Classes:
C07K14/725; C12N15/12; C12Q1/68; (IPC1-7): C12Q1/68; C07H21/04; C07K14/725; C12N15/12; C12P19/34
Foreign References:
| US20010014460A1 | 2001-08-16 | |||
| US5830652A | 1998-11-03 | |||
| US6303750B1 | 2001-10-16 |
Other References:
MAGEED ET AL.: "Immunopathology and the gene therapy of lupus", GENE THERAPY, vol. 10, 2003, pages 861 - 874, XP002967504
TAKAI T.: "Roles of Fc receptors in autoimmunity", vol. 2, August 2002 (2002-08-01), pages 580 - 592, XP002967505
JIANG ET AL.: "Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus", INTERNATIONAL IMMUNOLOGY, vol. 11, no. 10, June 1999 (1999-06-01), pages 1685 - 1691, XP002967506
KYOGOKU ET AL.: "Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus", ARTHRITIS & RHEUMATSM, vol. 46, no. 5, May 2002 (2002-05-01), pages 1242 - 1254, XP002967507
TAKAI T.: "Roles of Fc receptors in autoimmunity", vol. 2, August 2002 (2002-08-01), pages 580 - 592, XP002967505
JIANG ET AL.: "Genetically determined aberrant down-regulation of FcgammaRIIB1 in germinal center B cells associated with hyper-IgG and IgG autoantibodies in murine systemic lupus erythematosus", INTERNATIONAL IMMUNOLOGY, vol. 11, no. 10, June 1999 (1999-06-01), pages 1685 - 1691, XP002967506
KYOGOKU ET AL.: "Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus", ARTHRITIS & RHEUMATSM, vol. 46, no. 5, May 2002 (2002-05-01), pages 1242 - 1254, XP002967507
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