Title:
FD CHAIN GENE OR L CHAIN GENE EACH CAPABLE OF INCREASING SECRETION AMOUNT OF FAB-TYPE ANTIBODY
Document Type and Number:
WIPO Patent Application WO/2014/175164
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing an antibody having a reduced molecular weight, such as a Fab-type antibody, using yeast as a host, whereby it becomes possible to produce the antibody having a reduced molecular weight with high productivity. According to the present invention, a gene is provided, in which a nucleotide sequence encoding an amino acid residue or an amino acid sequence each capable of increasing the secretion amount of a Fab-type antibody is contained at the 3'-terminal of a nucleotide sequence encoding an amino acid sequence for an Fd chain or an L chain of an antibody.
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Inventors:
NISHIYAMA TOZO (JP)
Application Number:
PCT/JP2014/060941
Publication Date:
October 30, 2014
Filing Date:
April 17, 2014
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12N15/09; C12N1/19; C12P21/08
Domestic Patent References:
| WO2012102171A1 | 2012-08-02 |
Foreign References:
| JP2009508486A | 2009-03-05 | |||
| JP2007215471A | 2007-08-30 | |||
| JP2006320220A | 2006-11-30 | |||
| JP2009082033A | 2009-04-23 |
Other References:
BIOTECHNOLOGY AND BIOENGINEERING, vol. 94, 2006, pages 353 - 361
"Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", GREENE PUBLISHING ASSOCIATES AND WILEY-INTERSCIENCE
"Molecular Cloning", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", GREENE PUBLISHING ASSOCIATES AND WILEY-INTERSCIENCE
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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