Title:
FERMENTED FOOD EXTRACT COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2015/147251
Kind Code:
A1
Abstract:
Provided is a fermented food extract that has a blood pressure-lowering action and is useful as a functional health food or pharmaceutical composition. This fermented food extract is obtained by: subjecting a fermented food, preferably a fermented fagopyrum esculentum lyophilisate, to acetone extraction; eluting the fermented fagopyrum esculentum acetone extract using a solid-phase extract cartridge filled with a resin to which a phenyl group is bonded, with formic acid-containing water used as an eluent; and fractionating and purifying the eluate using a column (PFP column) filled with a carrier to which a pentafluorophenyl group is bonded, with formic acid/methanol-containing water used as a mobile phase. This functional health food or pharmaceutical composition contains said extract or at least a part thereof as an active ingredient.
Inventors:
NAKAMURA KOZO (JP)
Application Number:
PCT/JP2015/059578
Publication Date:
October 01, 2015
Filing Date:
March 27, 2015
Export Citation:
Assignee:
UNIV SHINSHU (JP)
International Classes:
A23L33/00; A61K31/221; A61K31/19; A61K31/194; A61K31/197; A61K31/198; A61K31/205; A61K36/70; A61P9/08; A61P9/12; A61P43/00
Foreign References:
| JP2012162503A | 2012-08-30 | |||
| JP2008239498A | 2008-10-09 | |||
| JP2007143473A | 2007-06-14 | |||
| JP2005304355A | 2005-11-04 | |||
| JPH04334323A | 1992-11-20 |
Other References:
MASAHIRO KOYAMA ET AL.: "Koketsuatsu Shizen Hassho Rat ni Okeru Hakko Kyobaku no Ketsuatsu Josho Yokusei Sayo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU (WEB, vol. 2014, 5 March 2014 (2014-03-05), pages 3B03a16
MASAHIRO KOYAMA ET AL.: "Soba Shokubutsutai o Genryo to shita Hakko Shokuhin ga Seitainai ACE Kassei ni Oyobosu Eikyo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2010, 2010, pages 176
MASAHIRO KOYAMA ET AL.: "Hakko Kyobaku ni Fukumareru Yuko Seibun no Dotei to Koatsu Sayo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU (WEB, vol. 2013, 2013, pages 2A15 P08
KOYAMA M. ET AL.: "Purification and identification of antihypertensive peptides from fermented buckwheat sprouts.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 12, 2013, pages 3013 - 3021, XP055224922, ISSN: 0021-8561
KOYAMA M. ET AL.: "Blood pressure-lowering peptides from neo-fermented buckwheat sprouts:A new approach to estimating ACE-inhibitory activity.", PLOS ONE, vol. 9, no. e105802, September 2014 (2014-09-01), pages 9
MASAHIRO KOYAMA ET AL.: "Soba Shokubutsutai o Genryo to shita Hakko Shokuhin ga Seitainai ACE Kassei ni Oyobosu Eikyo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU, vol. 2010, 2010, pages 176
MASAHIRO KOYAMA ET AL.: "Hakko Kyobaku ni Fukumareru Yuko Seibun no Dotei to Koatsu Sayo", JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY TAIKAI KOEN YOSHISHU (WEB, vol. 2013, 2013, pages 2A15 P08
KOYAMA M. ET AL.: "Purification and identification of antihypertensive peptides from fermented buckwheat sprouts.", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 61, no. 12, 2013, pages 3013 - 3021, XP055224922, ISSN: 0021-8561
KOYAMA M. ET AL.: "Blood pressure-lowering peptides from neo-fermented buckwheat sprouts:A new approach to estimating ACE-inhibitory activity.", PLOS ONE, vol. 9, no. e105802, September 2014 (2014-09-01), pages 9
Attorney, Agent or Firm:
KUZUWA, Kiyoshi (JP)
Seiji Kuzuwa (JP)
Seiji Kuzuwa (JP)
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