Title:
FGFR INHIBITOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/153373
Kind Code:
A1
Abstract:
An azatricyclic compound (as represented by formula I) which acts as an inhibitor of fibroblast growth factor receptors (FGFR), as well as a pharmaceutical composition thereof, a preparation method, and a use therefor in the treatment of FGFR-mediated diseases. The azatricyclic compound exerts an effect by means of participating in the regulation of a plurality of processes such as cell proliferation, apoptosis, migration, neovascularization, and the like. AA%%%Formula (I)
Inventors:
XU XIAOFENG (CN)
WANG JIABING (CN)
DING LIEMING (CN)
LIU XIANGYONG (CN)
WANG JIABING (CN)
DING LIEMING (CN)
LIU XIANGYONG (CN)
Application Number:
PCT/CN2018/077314
Publication Date:
August 30, 2018
Filing Date:
February 27, 2018
Export Citation:
Assignee:
BETTA PHARMACEUTICALS CO LTD (CN)
International Classes:
A61K31/437; C07D471/14; A61K31/4375; A61K31/4985; A61P35/00; C07D519/00
Domestic Patent References:
| WO2003082871A1 | 2003-10-09 | |||
| WO2013007708A1 | 2013-01-17 |
Foreign References:
| CN105481858A | 2016-04-13 | |||
| EP2543372A1 | 2013-01-09 | |||
| DE2929414A1 | 1981-02-05 | |||
| US4666812A | 1987-05-19 |
Other References:
PEIJUAN DU, CHEMISTRY & BIOENGINEERING, vol. 31, no. 12, 2014, pages 5 - 8
BAE J HSCHLESSINGER J., MOLECULES AND CELLS, vol. 29, no. 5, 2010, pages 443 - 448
DAILEY LAMBROSTTI DMANSUKHANI A ET AL., CYTOKINE & GROWTH FACTOR REVIEWS, vol. 16, no. 2, 2005, pages 233 - 247
MASARU KATOH, INTERNATONAL JOURNAL OF MOLECULAR MEDICINE, vol. 38, 2016, pages 3 - 15
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 3587419A4
BAE J HSCHLESSINGER J., MOLECULES AND CELLS, vol. 29, no. 5, 2010, pages 443 - 448
DAILEY LAMBROSTTI DMANSUKHANI A ET AL., CYTOKINE & GROWTH FACTOR REVIEWS, vol. 16, no. 2, 2005, pages 233 - 247
MASARU KATOH, INTERNATONAL JOURNAL OF MOLECULAR MEDICINE, vol. 38, 2016, pages 3 - 15
"Design of Prodrugs", 1985, ELSEVIER
See also references of EP 3587419A4
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