Title:
FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/113584
Kind Code:
A1
Abstract:
Provided are an FGFR4 inhibitor having the structure of formula (I), and a preparation method therefor and the use thereof. The compound has a very strong inhibitory effect on FGFR4 kinase activity and has a very high selectivity, and can be widely used in the preparation of a drug for treating cancers, especially prostate cancer, liver cancer, pancreatic cancer, esophageal carcinomas, gastric cancer, lung cancer, breast cancer, ovarian carcinomas, colon cancer, skin cancer, glioblastomas or rhabdomyosarcomas, and is expected to be developed into a new generation of FGFR4 inhibitor drugs.
More Like This:
Inventors:
YANG FEI (CN)
DENG HAIBING (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
DENG HAIBING (CN)
YING HAIYAN (CN)
YU HONGPING (CN)
CHEN ZHUI (CN)
XU YAOCHANG (CN)
Application Number:
PCT/CN2017/116186
Publication Date:
June 28, 2018
Filing Date:
December 14, 2017
Export Citation:
Assignee:
ABBISKO THERAPEUTICS CO LTD (CN)
International Classes:
C07D471/04; A61K31/437; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61P35/00; C07D239/84; C07D475/00
Foreign References:
| CN105307657A | 2016-02-03 | |||
| CN104540809A | 2015-04-22 | |||
| CN105658642A | 2016-06-08 |
Other References:
ESWARAKUMAR ET AL., CYTOKINE GROWTH FACTOR, 2005, pages 139 - 149
ORNITZITOH, GENOME BIOL2, 2001
ULLRICHSCHLESSINGER, CELL, vol. 61, 1990, pages 203
POWERS ET AL., ENDOCR RELAT CANCER, vol. 7, 2000, pages 165 - 197
CHESI ET AL., BLOOD, vol. 97, 2001, pages 729 - 726
GOWARDHAN ET AL., BR J CANCER, vol. 92, 2005, pages 320 - 327
JAAKKOLA ET AL., INT J CANCER, vol. 54, 1993, pages 378 - 282
JANG ET AL., CANCER RES, vol. 61, 2001, pages 3541 - 3543
SHARIFF ET AL., EXPERT REV GASTROENTEROL HEPATO, vol. 13, 2009, pages 353 - 367
YE ET AL., CANCER, 2011, pages 5304 - 5313
XU ET AL., BMC CANCER, vol. 11, 2011, pages 84
FAWDAR ET AL., PNAS, vol. 110, 2013, pages 12426 - 12431
See also references of EP 3524603A4
ORNITZITOH, GENOME BIOL2, 2001
ULLRICHSCHLESSINGER, CELL, vol. 61, 1990, pages 203
POWERS ET AL., ENDOCR RELAT CANCER, vol. 7, 2000, pages 165 - 197
CHESI ET AL., BLOOD, vol. 97, 2001, pages 729 - 726
GOWARDHAN ET AL., BR J CANCER, vol. 92, 2005, pages 320 - 327
JAAKKOLA ET AL., INT J CANCER, vol. 54, 1993, pages 378 - 282
JANG ET AL., CANCER RES, vol. 61, 2001, pages 3541 - 3543
SHARIFF ET AL., EXPERT REV GASTROENTEROL HEPATO, vol. 13, 2009, pages 353 - 367
YE ET AL., CANCER, 2011, pages 5304 - 5313
XU ET AL., BMC CANCER, vol. 11, 2011, pages 84
FAWDAR ET AL., PNAS, vol. 110, 2013, pages 12426 - 12431
See also references of EP 3524603A4
Attorney, Agent or Firm:
XU & PARTNERS,LLC. (CN)
Download PDF: