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Title:
FGFR4 INHIBITOR AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/090973
Kind Code:
A1
Abstract:
Provided are a class of compounds as shown in formula (I) as FGFR4 inhibitors, and pharmaceutically acceptable salts thereof, preparation methods therefor and the use thereof in the preparation of drugs for treating FGFR4-related conditions.

Inventors:
CHEN ZHENGXIA (CN)
LONG CHAOFENG (CN)
ZHANG YANG (CN)
CHEN XIAOXIN (CN)
WANG YIKAI (CN)
DAI MEIBI (CN)
LIU XING (CN)
ZHAO HAIXIA (CN)
LIU ZHUOWEI (CN)
HU GUOPING (CN)
LI JIAN (CN)
CHEN SHUHUI (CN)
Application Number:
PCT/CN2017/111634
Publication Date:
May 24, 2018
Filing Date:
November 17, 2017
Export Citation:
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Assignee:
GUANGDONG ZHONGSHENG PHARMACEUTICAL CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07D213/74; A61K31/4418; A61K31/505; A61K31/506; A61P35/00; C07D239/42; C07D403/12; C07D405/12
Domestic Patent References:
WO2016164703A12016-10-13
WO2016115412A12016-07-21
WO2014139465A12014-09-18
WO2012136099A12012-10-11
WO2007082434A12007-07-26
Foreign References:
CN105899490A2016-08-24
Other References:
MO, CHENG ET AL.: "2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors", ASC MED. CHEM. LETT., vol. 8, no. 5, 31 March 2017 (2017-03-31), pages 543 - 548, XP055503030, ISSN: 1948-5875
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: doi:10.1002/jps.2600660104
See also references of EP 3543227A4
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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