Title:
FIBROBLAST GROWTH FACTOR-HEPARIN COMPLEX BOUND BY CHEMICAL REACTION AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2017/159943
Kind Code:
A1
Abstract:
The present invention relates to a fibroblast growth factor (FGF)-heparin complex in which a fibroblast growth factor and heparin are bound. Specifically, the bond is formed by chemically binding (i) an amine group of at least one lysine in amino acids constituting the fibroblast growth factor with a carboxyl group of heparin, or (ii) a thiol group of at least one cysteine in amino acids constituting the fibroblast growth factor with a vinyl group added to heparin. In addition, the present invention provides a method for preparing a fibroblast growth factor-heparin complex.
Inventors:
HONG JIN KEE (KR)
HAN EUI YOUNG (KR)
HAN EUI YOUNG (KR)
Application Number:
PCT/KR2016/011078
Publication Date:
September 21, 2017
Filing Date:
October 04, 2016
Export Citation:
Assignee:
CHUNG-ANG UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
International Classes:
C07K14/50; C07K19/00; C08B37/00; C12N5/00
Domestic Patent References:
| WO2013082196A1 | 2013-06-06 |
Foreign References:
| JPH07149797A | 1995-06-13 | |||
| US20040229249A1 | 2004-11-18 |
Other References:
FAHAM ET AL.: "Heparin Structure and Interactions with Basic Fibroblast Growth Factor", SCIENCE, vol. 271, 23 February 1996 (1996-02-23), pages 1116 - 1120, XP055422678
DIGABRIELE ET AL.: "Structure of a Heparin-linked Biologically Active Dimer of Fibroblast Growth Factor", NATURE, vol. 393, 1998, pages 812 - 817, XP055551667
DIGABRIELE ET AL.: "Structure of a Heparin-linked Biologically Active Dimer of Fibroblast Growth Factor", NATURE, vol. 393, 1998, pages 812 - 817, XP055551667
Attorney, Agent or Firm:
PCR INTELLECTUAL PROPERTY LAW FIRM (KR)
Download PDF:
Previous Patent: STEM FIXING DEVICE AND STEM SUPPORT INSERTION DEVICE COMPRISING SAME
Next Patent: WIRING BOOKBINDING DEVICE
Next Patent: WIRING BOOKBINDING DEVICE