Title:
FIBROBLAST GROWTH FACTOR RECEPTOR-1 INHIBITORS AND METHODS OF TREATMENT THEREOF
Document Type and Number:
WIPO Patent Application WO2005037235
Kind Code:
A3
Abstract:
The present invention is directed to an antibody or fragments thereof that are specific for a fibroblast growth factor receptor (FGFR)-1(IIIb), FGFR-1(IIIc), and/or FGFR-4. Also, provided herein, are vectors and host cells comprising the nucleic acids encoding those antibodies. The present invention further provides methods of antagonizing FGFR-1 or FGFR-4 as a treatment for obesity, diabetes, or a condition related thereto, and methods of reducing food intake.
Inventors:
SUN HAIJUN (US)
SHEN JUQUN (US)
TONRA JAMES R (US)
SHEN JUQUN (US)
TONRA JAMES R (US)
Application Number:
PCT/US2004/034970
Publication Date:
December 22, 2005
Filing Date:
October 18, 2004
Export Citation:
Assignee:
IMCLONE SYSTEMS INC (US)
SUN HAIJUN (US)
SHEN JUQUN (US)
TONRA JAMES R (US)
SUN HAIJUN (US)
SHEN JUQUN (US)
TONRA JAMES R (US)
International Classes:
A61K39/395; C07K16/28; A61K; (IPC1-7): A61K39/395
Domestic Patent References:
| WO2003063893A2 | 2003-08-07 |
Other References:
See also references of EP 1680140A4
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