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Title:
FILLER FOR AFFINITY CHROMATOGRAPHY
Document Type and Number:
WIPO Patent Application WO/2011/125674
Kind Code:
A1
Abstract:
The disclosed filler for affinity chromatography has a high dynamic binding capacity for proteins, excellent alkali resistance, and excellent storage stability. Said filler contains porous particles comprising a copolymer of: between 40 and 99.5 mass parts of a methacryloyl-group-containing vinyl monomer (M-1) that contains a hydroxide group but no epoxy groups; between 0.5 and 30 mass parts of an epoxy-group-containing vinyl monomer (M-2); between 0 and 59.5 mass parts of a methacryloyl-group-containing vinyl monomer (M-3) other than (M-1) and (M-2); and between 0 and 25 mass parts of a vinyl monomer (M-4) other than (M-1), (M-2), and (M-3). The amounts of (M-1), (M-2), (M-3), and (M-4) sum to 100 mass parts. The disclosed filler also contains: ring-opened epoxy groups obtained by ring-opening epoxy groups in the aforementioned copolymer; and ligands bound to the porous particles.

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Inventors:
TAMORI, Kouji (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
田守　功二 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
ABE, Takayoshi (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
安陪　毅由 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
OKANO, Yusuke (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
岡野　友亮 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
MOMIYAMA, Masaki (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
籾山　昌輝 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
KAWAI, Hiroshi (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
Application Number:
JP2011/057886
Publication Date:
October 13, 2011
Filing Date:
March 29, 2011
Export Citation:
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Assignee:
JSR CORPORATION (9-2 Higashi-Shinbashi 1-chome, Minato-ku Tokyo, 40, 〒1058640, JP)
ＪＳＲ株式会社 (〒40 東京都港区東新橋一丁目９番２号 Tokyo, 〒1058640, JP)
TAMORI, Kouji (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
田守　功二 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
ABE, Takayoshi (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
安陪　毅由 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
OKANO, Yusuke (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
岡野　友亮 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
MOMIYAMA, Masaki (9-2 Higashi-shinbashi 1-chome, Minato-k, Tokyo 40, 〒1058640, JP)
籾山　昌輝 (〒40 東京都港区東新橋一丁目９番２号　ＪＳＲ株式会社内 Tokyo, 〒1058640, JP)
International Classes:
G01N30/88; B01D15/08; B01J20/24; C08F8/00; C08F220/26
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyoch, Chuo-ku Tokyo 13, 〒1030013, JP)
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