Title:
FILM-COATING COMPOSITION, SOLID ORAL FORMULATION, AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2016/072179
Kind Code:
A1
Abstract:
Provided are a film-coating composition with which tablets are made less likely to adhere to each other even when coating is performed using PVA having a degree of saponification of 85.0-89.0 mol% without adding any additives other than PVA, an oral solid formulation in which the film-coating composition is used, and a method for producing this formulation. This film-coating composition includes a PVA polymer having an average degree of saponification of 85.0-89.0 mol% and fulfilling requirement (A) or (B). Requirement (A): The transparency at 20°C of a solution obtained by adding 130.0 mL of 1-propanol to 100.0 g of a 5.0 mass% aqueous solution of PVA polymer and stirring is 50.0% or less. Requirement (B): The concentration of a supernatant obtained by allowing a solution, obtained by adding 230.0 mL of 1-propanol to 100.0 g of a 5.0 mass% aqueous solution of PVA polymer and stirring, to stand for 24 hours at 20°C is 0.75 mass% or higher.
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Inventors:
KAWADA SHOTARO (JP)
KAWANISHI MASATOSHI (JP)
KAWANISHI MASATOSHI (JP)
Application Number:
PCT/JP2015/077760
Publication Date:
May 12, 2016
Filing Date:
September 30, 2015
Export Citation:
Assignee:
JAPAN VAM & POVAL CO LTD (JP)
International Classes:
A61K47/34; A61K9/32; C09D129/04
Foreign References:
JPS5942325A | 1984-03-08 | |||
JP2008074770A | 2008-04-03 | |||
JP2011195672A | 2011-10-06 | |||
JP2002105383A | 2002-04-10 | |||
JPS56144705A | 1981-11-11 |
Other References:
SHOTARO KAWADA ET AL.: "PVA no Kakushu Parameter no Jozai Coating eno Eikyo", THE 31ST SEIZAI TO RYUSHI SEKKEI SYMPOSIUM KOEN YOSHISHU, 10 October 2014 (2014-10-10), pages 62 - 63
MASATOSHI KAWANISHI ET AL.: "Iyaku Grade PVA no Shokai", THE 30TH SEIZAI TO RYUSHI SEKKEI SYMPOSIUM KOEN YOSHISHU, 2013, pages 38
MASATOSHI KAWANISHI ET AL.: "Iyaku Grade PVA no Shokai", THE 30TH SEIZAI TO RYUSHI SEKKEI SYMPOSIUM KOEN YOSHISHU, 2013, pages 38
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
Tatsu Iwatani (JP)
Tatsu Iwatani (JP)
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