Title:
FILTRATION METHOD FOR PROTEIN-CONTAINING LIQUID
Document Type and Number:
WIPO Patent Application WO/2018/230397
Kind Code:
A1
Abstract:
A filtration method for a protein-containing liquid, said liquid containing a protein at a concentration of 20-100 mg/mL inclusive, which comprises a prefiltration step for filtering the protein-containing liquid through a prefilter, said prefilter having a pore diameter of 0.08-0.25 μm and comprising a hydrophobic resin, and a virus removal step for, after the prefiltration step, filtering the protein-containing liquid through a virus removal membrane comprising a synthetic polymer, wherein the protein-containing liquid before subjected to the prefiltration step contains a trimeric or larger protein multimer, which has an average diameter of less than 100 nm, in an amount of 0.25 g or greater per square meter of the virus removal membrane.
Inventors:
IWASAKI TAKUMA (JP)
YOKOYAMA YOSHIRO (JP)
YOKOYAMA YOSHIRO (JP)
Application Number:
PCT/JP2018/021574
Publication Date:
December 20, 2018
Filing Date:
June 05, 2018
Export Citation:
Assignee:
ASAHI KASEI MEDICAL CO LTD (JP)
International Classes:
B01D61/14; B01D61/16; B01D61/58; B01D63/08; B01D65/02; B01D69/12; B01D71/34; B01D71/56; B01D71/68; A61K38/00; A61K39/395; A61P31/12
Domestic Patent References:
| WO2015156403A1 | 2015-10-15 | |||
| WO2012176876A1 | 2012-12-27 | |||
| WO2001028667A1 | 2001-04-26 |
Foreign References:
| JP2012519065A | 2012-08-23 | |||
| JPH08164328A | 1996-06-25 | |||
| JP2001120960A | 2001-05-08 | |||
| JP2004277323A | 2004-10-07 | |||
| US20160176921A1 | 2016-06-23 |
Other References:
MANABE.S: "Removal of virus through novel membrane filtration method.", DEV. BIOL. STAND., vol. 88, 1996, pages 81 - 90
BRANDWEIN H ET AL.: "Membrane filtration for virus removal.", DEV BIOL (BASEL, vol. 102, 2000, pages 157 - 63, XP055315724
ARANHA-CREADO ET AL.: "Clearance of murine leukaemia virus from monoclonal antibody solution by a hydrophilic PVDF microporous membrane filter", BIOLOGICALS, vol. 26, no. 2, June 1998 (1998-06-01), pages 167 - 72, XP001543186, DOI: 10.1006/biol.1998.0130
L. MOCE-LLIVINA ET AL.: "Comparison of polyvinylidene fluoride and polyether sulfone membranes in filtering viral suspensions", JOURNAL OF VIROLOGICAL METHODS, vol. 109, no. 1, April 2003 (2003-04-01), pages 99 - 101
BIOTECHNOL. PROG., vol. 31, no. 3, 2015
MASANOBU YOKOGI: "Virus Separation by Cellulose Hollow Fiber Membrane", SEN'I TO KOGYO, vol. 55, no. 10, 1999
"Experimental Study of Viruses, General", pages: 479 - 480
BRANDWEIN H ET AL.: "Membrane filtration for virus removal.", DEV BIOL (BASEL, vol. 102, 2000, pages 157 - 63, XP055315724
ARANHA-CREADO ET AL.: "Clearance of murine leukaemia virus from monoclonal antibody solution by a hydrophilic PVDF microporous membrane filter", BIOLOGICALS, vol. 26, no. 2, June 1998 (1998-06-01), pages 167 - 72, XP001543186, DOI: 10.1006/biol.1998.0130
L. MOCE-LLIVINA ET AL.: "Comparison of polyvinylidene fluoride and polyether sulfone membranes in filtering viral suspensions", JOURNAL OF VIROLOGICAL METHODS, vol. 109, no. 1, April 2003 (2003-04-01), pages 99 - 101
BIOTECHNOL. PROG., vol. 31, no. 3, 2015
MASANOBU YOKOGI: "Virus Separation by Cellulose Hollow Fiber Membrane", SEN'I TO KOGYO, vol. 55, no. 10, 1999
"Experimental Study of Viruses, General", pages: 479 - 480
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
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