Title:
FINE PARTICLE, PROPHYLACTIC DRUG OR THERAPEUTIC DRUG FOR PARKINSON'S DISEASE, AND METHOD FOR IMPROVING PARKINSON'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2023/190267
Kind Code:
A1
Abstract:
Provided are, comprising miRNA downregulated in Parkinson's disease or miRNA used for the treatment of Parkinson's disease: a fine particle containing a prescribed miRNA of interest as a therapeutic means for Parkinson's disease; a prophylactic drug or therapeutic drug for Parkinson's disease; and a method for improving Parkinson's disease.
Inventors:
KOGA SHOJI (JP)
Application Number:
PCT/JP2023/012051
Publication Date:
October 05, 2023
Filing Date:
March 24, 2023
Export Citation:
Assignee:
DEXON PHARMACEUTICALS INC (JP)
International Classes:
A61K31/7105; A61K35/12; A61K35/32; A61K48/00; A61P25/16
Other References:
NARBUTE KARĪNA, PIĻIPENKO VLADIMIRS, PUPURE JOLANTA, DZIRKALE ZANE, JONAVIČĖ UGNĖ, TUNAITIS VIRGINIJUS, KRIAUČIŪNAITĖ KAROLINA, JA: "Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats", STEM CELLS TRANSLATIONAL MEDICINE, ALPHAMED PRESS, INC., US, vol. 8, no. 5, 1 May 2019 (2019-05-01), US , pages 490 - 499, XP093094866, ISSN: 2157-6564, DOI: 10.1002/sctm.18-0162
VENUGOPAL CHAITRA, K SHOBHA, RAI KIRANMAI S., PINNELLI VENKATA BHARATKUMAR, KUTTY BINDU M., DHANUSHKODI ANANDH: "Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano", CURRENT GENE THERAPY, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 18, no. 5, 12 November 2018 (2018-11-12), NL , pages 307 - 323, XP093094869, ISSN: 1566-5232, DOI: 10.2174/1566523218666180913152615
SHARMA YOGITA, SHOBHA K, SUNDEEP MATA, PINNELLI VENKATA BHARATKUMAR, PARVEEN SHAGUFTA, DHANUSHKODI ANANDH: "Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease", CNS & NEUROLOGICAL DISORDERS, BENTHAM SCIENCE PUBLISHERS LTD.,, NL, vol. 21, no. 1, 1 January 2022 (2022-01-01), NL , pages 62 - 76, XP093094873, ISSN: 1871-5273, DOI: 10.2174/1871527320666210311122921
AKVILE JARMALAVICIUTE VIRGINIJUS TUNAITIS, UGNE PIVORAITE, ALGIRDAS VENALIS, AUGUSTAS PIVORIUNAS: "Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis", CYTOTHERAPY, ISIS MEDICAL MEDIA, OXFORD,, GB, vol. 17, no. 7, 1 July 2015 (2015-07-01), GB , pages 932 - 939, XP055434854, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2014.07.013
VENUGOPAL CHAITRA, K SHOBHA, RAI KIRANMAI S., PINNELLI VENKATA BHARATKUMAR, KUTTY BINDU M., DHANUSHKODI ANANDH: "Neuroprotection by Human Dental Pulp Mesenchymal Stem Cells: From Billions to Nano", CURRENT GENE THERAPY, BENTHAM SCIENCE PUBLISHERS LTD., NL, vol. 18, no. 5, 12 November 2018 (2018-11-12), NL , pages 307 - 323, XP093094869, ISSN: 1566-5232, DOI: 10.2174/1566523218666180913152615
SHARMA YOGITA, SHOBHA K, SUNDEEP MATA, PINNELLI VENKATA BHARATKUMAR, PARVEEN SHAGUFTA, DHANUSHKODI ANANDH: "Neural Basis of Dental Pulp Stem Cells and its Potential Application in Parkinson’s Disease", CNS & NEUROLOGICAL DISORDERS, BENTHAM SCIENCE PUBLISHERS LTD.,, NL, vol. 21, no. 1, 1 January 2022 (2022-01-01), NL , pages 62 - 76, XP093094873, ISSN: 1871-5273, DOI: 10.2174/1871527320666210311122921
AKVILE JARMALAVICIUTE VIRGINIJUS TUNAITIS, UGNE PIVORAITE, ALGIRDAS VENALIS, AUGUSTAS PIVORIUNAS: "Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis", CYTOTHERAPY, ISIS MEDICAL MEDIA, OXFORD,, GB, vol. 17, no. 7, 1 July 2015 (2015-07-01), GB , pages 932 - 939, XP055434854, ISSN: 1465-3249, DOI: 10.1016/j.jcyt.2014.07.013
Attorney, Agent or Firm:
SUGAWARA Tetsuro (JP)
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