FIVE-MEMBERED HETEROCYCLIC COMPOUNDS - TAKEDA CHEMICAL INDUSTRIES LTD

Title:

FIVE-MEMBERED HETEROCYCLIC COMPOUNDS

Document Type and Number:

WIPO Patent Application WO/2004/024705

Kind Code:

A1

Abstract:

Compounds represented by the general formula (&Verbar ) or salts thereof, which have excellent effects of lowering the weight of fatty tissue, blood sugar level and blood lipid level and are useful as preventive and therapeutic agents for obesity, diabetes, hyperlipidemia, impaired glucose tolerance, hypertension, and so on: (&Verbar ) wherein R¹ is a group derived from an optionally substituted five-membered heterocycle; X, Y and V are each independently a free bond, oxygen, sulfur, or the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; A is an aromatic ring which may have one to three additional substituents; Z is -(CH₂)_n-Z¹- or -Z¹-(CH₂)_n- (wherein n is an integer of 0 to 8 and Z¹ is a free bond, oxygen, sulfur, or the like); B is a nitrogenous heterocycle which may have one to three additional substituents; W is a free bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; and R² is hydrogen, cyano, -PO(OR⁹)(OR¹⁰) (wherein R⁹ and R¹⁰ are each independently hydrogen or optionally substituted hydrocarbyl, or R⁹ and R¹⁰ may be united to form an optionally substituted ring), or the like.

Inventors:

MOMOSE YU (JP)
TAKAKURA NOBUYUKI (JP)
MAEKAWA TSUYOSHI (JP)
ODAKA HIROYUKI (JP)
KIMURA HIROYUKI (JP)

Application Number:

PCT/JP2003/011511

Publication Date:

March 25, 2004

Filing Date:

September 09, 2003

Export Citation:

Click for automatic bibliography generation Help

Assignee:

TAKEDA CHEMICAL INDUSTRIES LTD (JP)
MOMOSE YU (JP)
TAKAKURA NOBUYUKI (JP)
MAEKAWA TSUYOSHI (JP)
ODAKA HIROYUKI (JP)
KIMURA HIROYUKI (JP)

International Classes:

A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P43/00; C07D263/32; C07F9/6558; (IPC1-7): C07D263/32; C07D413/12; C07D413/14; C07D417/14; C07D417/12; C07D401/14; C07D403/12; C07F7/18; C07F9/6558; A61K31/422; A61K31/4439; A61K31/427; A61K31/4245; A61K31/454; A61K31/5377; A61K31/675; A61K31/695; A61K31/662; A61P3/06; A61P3/04; A61P3/10; A61P9/12; A61P43/00

Domestic Patent References:

WO2001016111A2	2001-03-08
WO2001000603A1	2001-01-04
WO1996013264A1	1996-05-09
WO2003015774A1	2003-02-27
WO2001038325A1	2001-05-31

Foreign References:

US4171365A	1979-10-16
GB2110211A	1983-06-15
JPS63159373A	1988-07-02
US4996216A	1991-02-26
US6214842B1	2001-04-10

Other References:

WINKELMANN,E ET AL.: "Chemotherapeutically Active Nitro Compounds", ARZNEIM.-FORSCH., vol. 28, no. 5, 1978, pages 739 - 749, XP000652674
WINKELMANN,E ET AL.: "Chemotherapeutically Active Nitro Compounds", ARZNEIM.-FORSCH., vol. 28, no. 3, 1978, pages 351 - 366, XP002974178
BALDWIN J.JOHN ET AL.: "Beta 1 - Selective Adrenoceptor Antagonists:Examples of the 2-[4-[3-(Substituted amino)-2-hydroxypropoxy]phenyl]imidazole Class. 2", JOURNAL OF MEDICINAL CHEMISTRY, vol. 29, no. 6, 1986, pages 1065 - 1080, XP002974179
MOMOSE,YU ET AL.: "Novel 5-Substituted-1H-tetrazole Derivative as Potent Glucose and Lipid Lowering Agents", CHEM.PHARM. BULL., vol. 50, no. 1, 1 January 2002 (2002-01-01), pages 100 - 111, XP001153123
MOMOSE, YU ET AL.: "Novel 5-Substituted 2,4-Thiazolidinedione and 2,4-Oxazolidinedione Derivatives as Insulin Sensitizers with Antidiabetic Activities.", J. MED. CHEM., vol. 45, no. 7, 28 March 2002 (2002-03-28), pages 1518 - 1534, XP002244369

Attorney, Agent or Firm:

Takahashi, Shuichi c/o Osaka Plant of TAKEDA CHEMICAL INDUSTRIES LTD. (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka, JP)

Download PDF:

View/Download PDF PDF Help

Previous Patent: NOVEL CARBOXAMIDE COMPOUNDS HAVING AN MCH-ANTAGONISTIC EFFECT, MEDICAMENTS CONTAINING SAID COMPOUNDS...

Next Patent: TAXANE DERIVATIVES FUNCTIONALIZED AT THE 14- POSITION AND A PROCESS FOR THE PREPARATION THEREOF