Title:
FIVE-MEMBERED RING HETEROARYL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2015/152254
Kind Code:
A1
Abstract:
The present invention provides a compound that has a strong α7 nicotinic acetylcholine receptor (α7 nAChR)-regulating effect and is useful as a therapeutic drug for diseases associated with cholinergicity of the central nervous system (CNS) and/or peripheral nervous system (PNS), diseases associated with smooth muscle contraction, endocrine diseases, diseases associated with neurodegeneration, etc. Provided is a compound of formula (I) or a pharmaceutically acceptable salt of said compound [In the formula, X-Y-Z represents N-CO-NR3AR3B or the like, A represents an optionally substituted phenyl or the like, B represents optionally substituted imidazole or the like, R2A, R2B, R2C, and R2D may be the same or different and represent hydrogen atoms or the like, and R3A and R3B may be the same or different and represent optionally substituted C3-10 cycloalkyls or the like].
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Inventors:
IWATA MITSUTAKA (JP)
ISHIDA KYOJI (JP)
SHIMADA NAOAKI (JP)
ISHIDA KYOJI (JP)
SHIMADA NAOAKI (JP)
Application Number:
PCT/JP2015/060155
Publication Date:
October 08, 2015
Filing Date:
March 31, 2015
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
C07D261/08; A61K31/42; A61K31/454; A61K31/4545; A61K45/00; A61P25/00; A61P25/14; A61P25/18; A61P25/28; A61P29/00; A61P43/00; C07D261/14; C07D401/04; C07D401/14; C07D413/04; C07D413/08; C07D413/14; C07D417/04; C07D417/14
Domestic Patent References:
| WO2007070433A2 | 2007-06-21 | |||
| WO1993020061A1 | 1993-10-14 | |||
| WO1996016049A1 | 1996-05-30 | |||
| WO2013083741A1 | 2013-06-13 | |||
| WO2014054635A1 | 2014-04-10 |
Other References:
FLIPO M. ET AL.: "Ethionamide Boosters. 2. Combining Bioisosteric Replacement and Structure-Based Drug Design To Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 55, no. 1, 2012, pages 68 - 83, XP055068481
DATABASE REGISTRY [o] 25 March 2010 (2010-03-25), retrieved from STN Database accession no. 1214439-84-5
CARROLL F. I.: "Epibatidine structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 8, 2004, pages 1889 - 96, XP009082279
DATABASE REGISTRY [o] 25 March 2010 (2010-03-25), retrieved from STN Database accession no. 1214439-84-5
CARROLL F. I.: "Epibatidine structure-activity relationships", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 8, 2004, pages 1889 - 96, XP009082279
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Mutsumi Sameshima (JP)
Mutsumi Sameshima (JP)
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