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Title:
FKI-1366 SUBSTANCES AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2005/023788
Kind Code:
A1
Abstract:
A microorganism belonging to Beauveria sp. and being capable of producing FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366, FERM BP-08459) is cultured in a medium and thus the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are accumulated in the culture medium. Then the FKI-1366 substance A and/or the FKI-1366 substance B and/or the FKI-1366 substance C are collected from the culture medium. The thus obtained FKI-1366 substance A, FKI-1366 substance B and FKI-1366 substance C or compositions thereof have an effect of potentiating the activity of azole antifungal agents. Thus, they act against various fungal infections such as deep-seated fungal infection at a low concentration and within a short time. Therefore, they are useful in lowering the appearance frequency of tolerant strains and overcoming tolerance, thereby being expected as useful drugs.

Inventors:
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
MASUMA ROKURO (JP)
ARAI MASAYOSHI (JP)
Application Number:
PCT/JP2003/011053
Publication Date:
March 17, 2005
Filing Date:
August 29, 2003
Export Citation:
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Assignee:
KITASATO INST (JP)
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
MASUMA ROKURO (JP)
ARAI MASAYOSHI (JP)
International Classes:
A61K31/395; A61P31/10; C07D273/00; C12P17/14; C12R1/645; (IPC1-7): C07D273/00; A61K31/395; A61P31/10; C12N1/14; C12P17/14
Other References:
LEE M.D. ET AL.: "Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance", FARMACO, vol. 56, no. 1-2, 2001, pages 81 - 85, XP002976515
OVCHINNIKOV Y.A. ET AL.: "The synthesis and some properties of beauvericin", TETRAHEDRON LETT., vol. 2, 1971, pages 159 - 162, XP000944316
PEETERS H. ET AL.: "Synthesis of beauvericin by a multifunctionasl enzyme", J. ANTIBIOT., vol. 41, no. 3, 1988, TOKYO, pages 352 - 359, XP002976516
SHEMYAKIN M.M. ET AL.: "The structure and total synthesis of enniatin B", TETRAHEDRON LETT., vol. 14, 1963, pages 885 - 890, XP002976517
See also references of EP 1659116A4
Attorney, Agent or Firm:
Kobayashi, Kazunori (25-1 Kitaotsuka 2-chom, Toshima-ku Tokyo, JP)
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