Title:
FLAVONIOD-DERIVED HES-1 PROMOTER INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2012/014848
Kind Code:
A1
Abstract:
[Problem] To provide an HES-1 promoter inhibitor which has strong HES-1 promoter inhibitory activity and which is less toxic to neural stem cells. [Solution] An HES-1 promoter inhibitor which comprises a compound represented by the general formula or a derivative thereof.
Inventors:
ARAI MIDORI (JP)
ISHIBASHI MASAMI (JP)
YANASE NATSUKI (JP)
KORYUDZU KAZUNE (JP)
ISHIBASHI MASAMI (JP)
YANASE NATSUKI (JP)
KORYUDZU KAZUNE (JP)
Application Number:
PCT/JP2011/066866
Publication Date:
February 02, 2012
Filing Date:
July 25, 2011
Export Citation:
Assignee:
UNIV CHIBA NAT UNIV CORP (JP)
ARAI MIDORI (JP)
ISHIBASHI MASAMI (JP)
YANASE NATSUKI (JP)
KORYUDZU KAZUNE (JP)
ARAI MIDORI (JP)
ISHIBASHI MASAMI (JP)
YANASE NATSUKI (JP)
KORYUDZU KAZUNE (JP)
International Classes:
A61K31/4433; A61P25/00; A61P25/28; A61P43/00; C07D405/06
Foreign References:
| JP2009057306A | 2009-03-19 |
Other References:
MIDORI ARAI: "Tennenbutsu-yo Kagobutsu o Jiku to shita Shinkei Kansaibo, Gan Saibo eno Approach", ABSTRACTS OF 130TH ANNUAL MEETING OF PHARMACEUTICAL SOCIETY OF JAPAN, 5 March 2010 (2010-03-05), pages 56
ARAI, M. A. ET AL.: "Efficient Synthesis of Chromone and Flavonoid Derivatives with Diverse Heterocyclic Units", CHEMISTRY. ASIAN JOURNAL, vol. 3, 2008, pages 2056 - 2064
ARAI, M. A. ET AL.: "The first Hes1 dimer inhibitors from natural products", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 5778 - 5781, XP026624085, DOI: doi:10.1016/j.bmcl.2009.07.146
KATAKURA, M. ET AL.: "Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells", NEUROSCIENCE, vol. 160, 2009, pages 651 - 660, XP026053855, DOI: doi:10.1016/j.neuroscience.2009.02.057
ARAI, M. A. ET AL.: "Approaches to Neural Stem Cells and Cancer Cells Based on Natural Products", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 59, no. 4, April 2011 (2011-04-01), pages 417 - 426
ARAI, M. A. ET AL.: "Efficient Synthesis of Chromone and Flavonoid Derivatives with Diverse Heterocyclic Units", CHEMISTRY. ASIAN JOURNAL, vol. 3, 2008, pages 2056 - 2064
ARAI, M. A. ET AL.: "The first Hes1 dimer inhibitors from natural products", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 5778 - 5781, XP026624085, DOI: doi:10.1016/j.bmcl.2009.07.146
KATAKURA, M. ET AL.: "Docosahexaenoic acid promotes neuronal differentiation by regulating basic helix-loop-helix transcription factors and cell cycle in neural stem cells", NEUROSCIENCE, vol. 160, 2009, pages 651 - 660, XP026053855, DOI: doi:10.1016/j.neuroscience.2009.02.057
ARAI, M. A. ET AL.: "Approaches to Neural Stem Cells and Cancer Cells Based on Natural Products", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 59, no. 4, April 2011 (2011-04-01), pages 417 - 426
Attorney, Agent or Firm:
INOUE HARUKI (JP)
Inoue Spring (JP)
Inoue Spring (JP)
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