Title:
FLAVONOID GLYCOSIDE-ORGANIC AMINE NEUROAGONIST DOUBLE SALT COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/089598
Kind Code:
A1
Abstract:
A flavonoid glycoside and organic amine neuroagonist double salt compound, a preparation method therefor, and an application thereof, a pharmaceutical composition containing a therapeutically effective amount of the double salt compound and an application thereof, and a double salt nanoparticle obtained from the double salt compound by nanogrinding and an application thereof. Flavonoid glycoside has a structural general formula represented by formula (1) below, wherein R1-R9 are each independently selected from -H,-OH, C1-C6 alkyl, alkoxy or substituted alkyl, and at least one of R1 and R2 is selected from -OH.
Inventors:
WANG HUALU (CN)
WANG LUYING (CN)
WANG LUYING (CN)
Application Number:
PCT/CN2021/127490
Publication Date:
May 05, 2022
Filing Date:
October 29, 2021
Export Citation:
Assignee:
HANGZHOU LALIN INTELLIGENCE SCIENCE AND TECH CO LTD (CN)
International Classes:
C07H17/07; A61K31/135; A61K31/7048; A61P9/10; A61P25/16; A61P25/28; C07C221/00; C07C225/18; C07H1/00
Foreign References:
| CN103596939A | 2014-02-19 | |||
| CN101848907A | 2010-09-29 | |||
| CN103209692A | 2013-07-17 |
Other References:
MA YI;LIN JIE: "Clinical analysis of donepezil combined with Dengzhan Shengmai capsule in the treatment of cognitive dysfunction in post-stroke patients", WORLD CLINICAL DRUGS, vol. 37, no. 10, 27 October 2016 (2016-10-27), pages 698 - 702, XP055925897, ISSN: 1672-9188, DOI: 10.13683/j.wph.2016.10.009
CAI XUEFENG;OU XIAOFAN;HUANG ZONGWEN;LIN SIGE;LIN JING: "Curative effect of Shenzhi capsules combined with donepezil on Parkinson's disease and its effect on levels of brain neurotransmitters and neurotrophic factors", PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA, vol. 34, no. 1, 15 February 2018 (2018-02-15), pages 170 - 174, XP055925902, DOI: 10.13412/j.cnki.zyyl.2018.01.043
YUAN LIJUAN;WANG KEREN;SANG ZHIPEI: "Research advances of multi-targeted flavonoids in the intervention of Alzheimer's disease ", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 49, no. 1, 25 February 2018 (2018-02-25), pages 10 - 19, XP055925910, ISSN: 1000-5048, DOI: 10.11665/j.issn.1000-5048.20180102
CAI XUEFENG;OU XIAOFAN;HUANG ZONGWEN;LIN SIGE;LIN JING: "Curative effect of Shenzhi capsules combined with donepezil on Parkinson's disease and its effect on levels of brain neurotransmitters and neurotrophic factors", PHARMACOLOGY AND CLINICS OF CHINESE MATERIA MEDICA, vol. 34, no. 1, 15 February 2018 (2018-02-15), pages 170 - 174, XP055925902, DOI: 10.13412/j.cnki.zyyl.2018.01.043
YUAN LIJUAN;WANG KEREN;SANG ZHIPEI: "Research advances of multi-targeted flavonoids in the intervention of Alzheimer's disease ", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 49, no. 1, 25 February 2018 (2018-02-25), pages 10 - 19, XP055925910, ISSN: 1000-5048, DOI: 10.11665/j.issn.1000-5048.20180102
Attorney, Agent or Firm:
ACIP LAW OFFICES (CN)
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