FLOW CELL MODULES AND LIQUID SAMPLE ANALYZERS AND METHODS INCLUDING SAME

WIPO Patent Application WO/2016/053613

A3

A flow cell (250) for a fluorescence spectrometer includes a flow channel (254) to receive a flow of a liquid sample, an excitation light entrance window to receive excitation light from a light source, and an emission light exit window to transmit fluorescent emission light from the liquid sample in the flow channel from the flow cell. The excitation light entrance window and/or emission light exit window includes a waveguide including: a waveguide core (261, 262) formed of a core material; and a cladding medium (274) surrounding a portion of the waveguide core (261, 262), wherein the cladding medium (274) has a refractive index less than the refractive index of the core material. The waveguide defines a portion of the flow channel (254). At least one mirror (270, 272) integral with the flow cell body is positioned to reflect excitation light that has passed through the liquid sample in the flow channel (254) back into the liquid sample and/or to reflect emission light emitted from the liquid sample toward the emission light exit window. The excitation light entrance window is spaced a first distance from the flow channel and the emission light exit window is spaced a second distance from the flow channel, whereby the second distance is less than the first distance.

DICESARE JOSEPH L (US)
JIN FENG (US)
NEAL TIMOTHY P (US)
AIKENS DAVID (US)

PCT/US2015/050143

May 26, 2016

September 15, 2015

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PERKINELMER HEALTH SCI INC (US)

G01N21/03; G01J3/44; G01N21/05; G01N21/64

JPH03108641A	1991-05-08
US20050161623A1	2005-07-28

BEATTY, David, D. (P.AP.O. Box 3742, Raleigh North Carolina, US)

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