Title:
FLOW CHANNEL STRUCTURE AND LIPID PARTICLE OR MICELLE FORMATION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2018/190423
Kind Code:
A1
Abstract:
Provided are: a flow channel structure with which lipid particles or micelles, which are useful as nano-sized carriers, for example, in drug delivery systems, are produced with good control of particle size; and a method for forming lipid particles or micelles using the same. Said flow channel structure has a two-dimensional structure such as one in which multiple structural elements (baffles) of a specified width are alternately disposed from the two side faces in a micro-sized flow channel through which feedstock solutions are flowed.
Inventors:
TOKESHI MANABU (JP)
MAEKI MASATOSHI (JP)
SATO YUSUKE (JP)
HARASHIMA HIDEYOSHI (JP)
MAEKI MASATOSHI (JP)
SATO YUSUKE (JP)
HARASHIMA HIDEYOSHI (JP)
Application Number:
PCT/JP2018/015550
Publication Date:
October 18, 2018
Filing Date:
April 13, 2018
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
B01J13/04; A61K9/127
Foreign References:
| JP2015502337A | 2015-01-22 | |||
| US20030031090A1 | 2003-02-13 | |||
| JP2006167600A | 2006-06-29 | |||
| CN101618308A | 2010-01-06 |
Other References:
MORIKAWA, ANRI: "Noteworthy Manufacturing Devices 1: Microreactors", DRUG SUBSTANCE MANUFACTURE, 27 October 2016 (2016-10-27), pages 1 - 3, XP009517282, Retrieved from the Internet [retrieved on 20180607]
CHANG C. C. ET AL.: "Computational analysis of electrokinetically driven flow mixing in microchannels with patterned blocks", JOURNAL OF MICROMECHANICS AND MICROENGINEERING, vol. 14, no. 4, 19 January 2004 (2004-01-19), pages 550 - 558, XP055559576, Retrieved from the Internet
M. MAEKIT. SAITOY. SATOT. YASUIN. KAJIA. ISHIDAH. TANIY. BABAH. HARASHIMAM. TOKESHI: "A Strategy for Synthesis of Lipid Nanoparticles Using Microfluidic Devices with a Mixer Structure", RSC ADVANCES, vol. 5, 2015, pages 46181
Y. SATOY. NOTEM. MAEKIN. KAJIY. BABAM. TOKESHIH. HARASHIMA: "Elucidation of the Physicochemical Properties and Potency of siRNA-Loaded Small-Sized Lipid Nanoparticles for siRNA Delivery", JOURNAL OF CONTROLLED RELEASE, vol. 229, 2016, pages 48, XP029521836, DOI: 10.1016/j.jconrel.2016.03.019
I. V. ZHIGALTSEVN. BELLIVEAUI. HAFEZA. K. K. LEUNGC. HANSENP. R. CULLIS: "Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing", LANGMUIR, vol. 38, 2012, pages 3633
D. CHENK. T. LOVEY. CHENA. A. ELTOUKHYC. KASTRUPG. SAHAYA. JEONY. DONGK. A. WHITEHEADD. G. ANDERSON: "Rapid Discovery of Protein siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 6948
CHANG C. C. ET AL.: "Computational analysis of electrokinetically driven flow mixing in microchannels with patterned blocks", JOURNAL OF MICROMECHANICS AND MICROENGINEERING, vol. 14, no. 4, 19 January 2004 (2004-01-19), pages 550 - 558, XP055559576, Retrieved from the Internet
M. MAEKIT. SAITOY. SATOT. YASUIN. KAJIA. ISHIDAH. TANIY. BABAH. HARASHIMAM. TOKESHI: "A Strategy for Synthesis of Lipid Nanoparticles Using Microfluidic Devices with a Mixer Structure", RSC ADVANCES, vol. 5, 2015, pages 46181
Y. SATOY. NOTEM. MAEKIN. KAJIY. BABAM. TOKESHIH. HARASHIMA: "Elucidation of the Physicochemical Properties and Potency of siRNA-Loaded Small-Sized Lipid Nanoparticles for siRNA Delivery", JOURNAL OF CONTROLLED RELEASE, vol. 229, 2016, pages 48, XP029521836, DOI: 10.1016/j.jconrel.2016.03.019
I. V. ZHIGALTSEVN. BELLIVEAUI. HAFEZA. K. K. LEUNGC. HANSENP. R. CULLIS: "Bottom-Up Design and Synthesis of Limit Size Lipid Nanoparticle Systems with Aqueous and Triglyceride Cores Using Millisecond Microfluidic Mixing", LANGMUIR, vol. 38, 2012, pages 3633
D. CHENK. T. LOVEY. CHENA. A. ELTOUKHYC. KASTRUPG. SAHAYA. JEONY. DONGK. A. WHITEHEADD. G. ANDERSON: "Rapid Discovery of Protein siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formation", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, 2012, pages 6948
Attorney, Agent or Firm:
INTECT INTERNATIONAL PATENT OFFICE et al. (JP)
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