Title:
FLOW-CYTOMETRIC AXIAL PATTERN ANALYSIS OF MULTICELLULAR ORGANISMS
Document Type and Number:
WIPO Patent Application WO2003016875
Kind Code:
A3
Abstract:
This invention relates to a method of using elongate multicellular organisms in conjunction with a specialized flow cytometer for drug discovery and compound screening. A stable, optically detectable linear marker pattern on each organism is used to construct a longitudinal map of each organism as it passes through the analysis region of the flow cytometer. This pattern is used to select and sort multicellular organisms based on particular phenotypic characteristics. The invention further combines the selection and sorting aspects with an identification aspect so that the genotype of each multicellular organism can be identified.
Inventors:
HANSEN W PETER (US)
FERRANTE ANTHONY A (US)
PERRAULT DONALD F (US)
GERSHMAN RUSSELL J (US)
KRAULEDAT PETRA B (US)
PULAK ROCK (US)
FERRANTE ANTHONY A (US)
PERRAULT DONALD F (US)
GERSHMAN RUSSELL J (US)
KRAULEDAT PETRA B (US)
PULAK ROCK (US)
Application Number:
PCT/US2002/026334
Publication Date:
September 04, 2003
Filing Date:
August 19, 2002
Export Citation:
Assignee:
UNION BIOMETRICA INC (US)
HANSEN W PETER (US)
FERRANTE ANTHONY A (US)
PERRAULT DONALD F (US)
GERSHMAN RUSSELL J (US)
KRAULEDAT PETRA B (US)
PULAK ROCK (US)
HANSEN W PETER (US)
FERRANTE ANTHONY A (US)
PERRAULT DONALD F (US)
GERSHMAN RUSSELL J (US)
KRAULEDAT PETRA B (US)
PULAK ROCK (US)
International Classes:
G01N15/02; G01N15/14; G01N33/50; (IPC1-7): G01N15/14
Domestic Patent References:
| WO2000036396A2 | 2000-06-22 | |||
| WO1999037814A1 | 1999-07-29 | |||
| WO2000011449A1 | 2000-03-02 |
Foreign References:
| US20020176069A1 | 2002-11-28 | |||
| US4110043A | 1978-08-29 | |||
| US4765737A | 1988-08-23 |
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