Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
FLUORENE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES
Document Type and Number:
WIPO Patent Application WO/2010/041748
Kind Code:
A1
Abstract:
Disclosed is a prophylactic or therapeutic agent for diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, heart failure, cardiomyopathy, myocardial ischemia, cerebral ischemia, stroke, pulmonary hypertension, hyperlactatemia, mitochondrial disorders, mitochondrial encephalomyopathy or cancer, i.e., a PDHK inhibitor or the like. Specifically disclosed is a compound represented by general formula [I], a pharmaceutically acceptable salt of the compound, or a solvate of the compound or the pharmaceutically acceptable salt. [In the formula, each symbol is as defined in the description.]

Inventors:
MOTOMURA TAKAHISA (JP)
NAGAMORI HIRONOBU (JP)
SUZAWA KOICHI (JP)
ITO HIROTSUGU (JP)
MORITA TORU (JP)
KOBAYASHI SATORU (JP)
SHINKAI HISASHI (JP)
Application Number:
PCT/JP2009/067668
Publication Date:
April 15, 2010
Filing Date:
October 09, 2009
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
JAPAN TOBACCO INC (JP)
MOTOMURA TAKAHISA (JP)
NAGAMORI HIRONOBU (JP)
SUZAWA KOICHI (JP)
ITO HIROTSUGU (JP)
MORITA TORU (JP)
KOBAYASHI SATORU (JP)
SHINKAI HISASHI (JP)
International Classes:
C07C35/52; A61K31/045; A61K31/05; A61K31/085; A61K31/10; A61K31/121; A61K31/136; A61K31/166; A61K31/167; A61K31/192; A61K31/235; A61K31/277; A61K31/381; A61K31/397; A61K31/40; A61K31/401; A61K31/41; A61K31/415; A61K31/4155; A61K31/4196; A61K31/421; A61K31/4245; A61K31/425; A61K31/435; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4439; A61K31/4453; A61K31/4523; A61K31/505; A61K31/5375; A61P3/00; A61P3/06; A61P3/10; A61P5/50; A61P9/04; A61P9/10; A61P35/00; A61P43/00; C07C39/42; C07C43/23; C07C43/253; C07C49/83; C07C59/54; C07C59/72; C07C65/17; C07C69/716; C07C69/76; C07C215/44; C07C215/70; C07C217/20; C07C233/18; C07C233/25; C07C235/06; C07C235/08; C07C235/42; C07C235/66; C07C255/12; C07C255/53; C07C259/10; C07C271/16; C07C271/30; C07C311/04; C07C317/22; C07D203/18; C07D205/04; C07D207/06; C07D207/16; C07D207/27; C07D213/30; C07D221/06; C07D231/12; C07D239/26; C07D249/08; C07D257/04; C07D263/32; C07D271/06; C07D271/10; C07D275/02; C07D295/08; C07D295/18; C07D333/22; C07D401/06; C07D401/12; C07D403/12; C07F7/10
Domestic Patent References:
WO2003011844A22003-02-13
Other References:
KARPOV, V. M. ET AL.: "Skeletal transformations of perfluoro-1-phenylindan under the action of antimony pentafluoride", JOURNAL OF FLUORINE CHEMISTRY, vol. 107, no. 1, 2001, pages 53 - 57, XP004228143
AICHER, T. D. ET AL.: "(R)-3,3,3-Trifluoro-2- hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 15, 1999, pages 2741 - 2746, XP002122777
See also references of EP 2345629A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Download PDF:



 
Previous Patent: WO/2010/041747

Next Patent: VIBRATION DAMPING DEVICE