Title:
FLUORESCENCE MODULATORS
Document Type and Number:
WIPO Patent Application WO/2012/110833
Kind Code:
A3
Abstract:
The present invention relates to fluorescence lifetime modulators, conjugates comprising fluorescence lifetime modulators moieties and methods of making them. The present invention further relates to the use of the fluorescence lifetime modulators and conjugates comprising the fluorescence lifetime modulator moieties for measuring the activity and detection of enzymes and for the study of protein-protein and protein-ligand interactions.
Inventors:
ANDERSON DAVID (GB)
MALTMAN BEATRICE (GB)
DUNSMORE COLIN (GB)
HARRISON TIMOTHY (GB)
COTTON GRAHAM (GB)
TIRNAVEANU ADINA-ELANA (GB)
MALTMAN BEATRICE (GB)
DUNSMORE COLIN (GB)
HARRISON TIMOTHY (GB)
COTTON GRAHAM (GB)
TIRNAVEANU ADINA-ELANA (GB)
Application Number:
PCT/GB2012/050374
Publication Date:
December 20, 2012
Filing Date:
February 20, 2012
Export Citation:
Assignee:
ALMAC SCIENCES SCOTLAND LTD (GB)
ANDERSON DAVID (GB)
MALTMAN BEATRICE (GB)
DUNSMORE COLIN (GB)
HARRISON TIMOTHY (GB)
COTTON GRAHAM (GB)
TIRNAVEANU ADINA-ELANA (GB)
ANDERSON DAVID (GB)
MALTMAN BEATRICE (GB)
DUNSMORE COLIN (GB)
HARRISON TIMOTHY (GB)
COTTON GRAHAM (GB)
TIRNAVEANU ADINA-ELANA (GB)
International Classes:
C07D209/82; C07C229/36; C07C309/40; C07D215/14; C07D241/46; C07D265/38; C07D271/12; C07D279/22; C07D307/80; C07D333/60; G01N33/542
Domestic Patent References:
| WO2002094778A2 | 2002-11-28 |
Foreign References:
| DE102007017051A1 | 2008-10-16 |
Other References:
B. KÖNIG ET AL, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 121, no. 8, 1999, pages 1681 - 1687, XP002680037
K. KAWAI ET AL, JOURNAL OF PHYSICAL CHEMISTRY B, vol. 112, no. 7, 2008, pages 2144 - 2149, XP002679797
H.-W. RHEE ET AL: "A Bifunctional Molecule as an Artificial Flavin Mononucleotide Cyclase and a Chemosensor for Selective Fluorescent Detection of Flavins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 29, 2009, pages 10107 - 10112, XP002680098
H.-W. RHEE ET AL: "Detection of Kinase Activity Using Versatile Fluorescence Quencher Probes", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, no. 29, 10 June 2010 (2010-06-10), pages 4919 - 4923, XP055014537, ISSN: 1433-7851, DOI: 10.1002/anie.201000879
O. WICHMANN ET AL, ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 45, 2006, pages 508 - 512, XP002680147
K. KAWAI ET AL, JOURNAL OF PHYSICAL CHEMISTRY B, vol. 112, no. 7, 2008, pages 2144 - 2149, XP002679797
H.-W. RHEE ET AL: "A Bifunctional Molecule as an Artificial Flavin Mononucleotide Cyclase and a Chemosensor for Selective Fluorescent Detection of Flavins", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 131, no. 29, 2009, pages 10107 - 10112, XP002680098
H.-W. RHEE ET AL: "Detection of Kinase Activity Using Versatile Fluorescence Quencher Probes", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, no. 29, 10 June 2010 (2010-06-10), pages 4919 - 4923, XP055014537, ISSN: 1433-7851, DOI: 10.1002/anie.201000879
O. WICHMANN ET AL, ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 45, 2006, pages 508 - 512, XP002680147
Attorney, Agent or Firm:
PRATT, Michelle (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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