Title:
FLUORESCENT COMPOUND, AND FLUORESCENTLY-LABELED BIOLOGICAL SUBSTANCE USING SAME
Document Type and Number:
WIPO Patent Application WO/2019/230963
Kind Code:
A1
Abstract:
Provided are: any one of the following fluorescent compounds; and a fluorescently-labeled biological substance having the compound. X represents CR5 or N, and R1-R7, Q1, Q2, L1, and L2 represent specific groups. The number of ring members in ring β1 and ring β2 are 5-8. At least one among R1-R7, Q1, Q2, L1, and L2 has a specific hydrophilic group. When the number of ring members in ring β1 and ring β2 is 6, and L1 and L2 are arylene groups, R5 is not a C18 or higher linear alkyl group-substituted aryl group. In addition to said definitions of ring β1, ring β2, L1, and L2, when R5 has a substituent having a dipyrometheneboron complex structure, the dipyrometheneboron complex structure has a structure in which a dipyrromethene skeleton is coordinated to a boron atom in a tridentate or tetradentate configuration.
Inventors:
NAKATA HIYOKU (JP)
WATANABE KOUSUKE (JP)
ASAKURA AKIHIRO (JP)
MAKITA KEIKO (JP)
KANAZAWA YOSHINORI (JP)
KANEKO KAZUHEI (JP)
WATANABE KOUSUKE (JP)
ASAKURA AKIHIRO (JP)
MAKITA KEIKO (JP)
KANAZAWA YOSHINORI (JP)
KANEKO KAZUHEI (JP)
Application Number:
PCT/JP2019/021770
Publication Date:
December 05, 2019
Filing Date:
May 31, 2019
Export Citation:
Assignee:
FUJIFILM CORP (JP)
International Classes:
C07F5/02; C09B23/00; C09K11/06; G01N21/64
Domestic Patent References:
| WO2013035303A1 | 2013-03-14 |
Foreign References:
| JP2013032297A | 2013-02-14 | |||
| JP2010184880A | 2010-08-26 | |||
| CN106946919A | 2017-07-14 | |||
| CN106947469A | 2017-07-14 | |||
| JP2016193907A | 2016-11-17 | |||
| US20090192298A1 | 2009-07-30 | |||
| JP2018106460A | 2018-07-05 | |||
| JP2019025958A | 2019-02-21 |
Other References:
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YAMAMURA, MASAKI ET AL.: "A facile and high-yield formation of dipyrrin-boronic acid dyads and triads: a light-harvesting system in the visible region based on the efficient energy transfer", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 13, no. 9, 7 March 2015 (2015-03-07), pages 2574 - 2581, XP055662065, ISSN: 1477-0520, DOI: 10.1039/C4OB02351J
SIRBU, DUMITRU ET AL.: "One-Pot Synthesis of a Mono-0,B,N-strapped BODIPY Derivative Displaying Bright Fluorescence in the Solid State", ORGANIC LETTERS, vol. 19, no. 7, 20 March 2017 (2017-03-20), pages 1626 - 1629, XP055662068, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00435
CHEN, NA ET AL.: "Sterically protected N20-type benzopyrromethene boron complexes from boronic acids with intense red/near-infrared fluorescence", ORGANIC LETTERS, vol. 19, no. 8, 2017331, pages 2026 - 2029, XP055662070, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.7b00601
DING, ZHAOYANG ET AL.: "Thermo-responsive fluorescent polymers with di verse LCSTs for ratiometric temperature sensing through FRET", POLYMERS (BASEL, SWITZER LAND, vol. 10, no. 3, 8 March 2018 (2018-03-08), pages 1 - 10, XP055662073, DOI: 10.3390/polym10030283
THE JOURNAL OF PHYSICAL CHEMISTRY A, vol. 120, 2016, pages 2537 - 2546
DEAN, JOHN, A: "Lange's Handbook of Chemistry", MCGRAW-HILL, article "PROPERTIES OF ATOMS, RADICALS, AND, BONDS"
J. ORG. CHEM., vol. 73, no. 5, 2008, pages 1963 - 1970
J. MATER. CHEM. B, vol. 2, 2014, pages 1576 - 1583
LUCAS C. D. DE REZENDEFLAVIO DA SILVA EMERY: "A Review of the Synthetic Strategies for the Development of BODIPY Dyes for Conjugation with Proteins", ORBITAL: THE ELECTRONIC JOURNAL OF CHEMISTRY, vol. 5, no. l, pages 62 - 83
CHEM. EUR. J., vol. 22, 2016, pages 93 - 96
ORG. PROCESS RES. DEV., vol. 19, 2015, pages 1774 - 1783
Attorney, Agent or Firm:
IIDA & PARTNERS et al. (JP)
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