FLUORESCENT GEL FOR GLUCOSE DETECTION AND CONTINUOUS GLUCOSE MONITORING METHOD USING SAME

Title:

FLUORESCENT GEL FOR GLUCOSE DETECTION AND CONTINUOUS GLUCOSE MONITORING METHOD USING SAME

Document Type and Number:

WIPO Patent Application WO/2018/135535

Kind Code:

A1

Abstract:

[Problem] To provide a novel fluorescent gel for glucose detection, in which gel fibrillation can be prevented even during prolonged implantation and which enables continuous glucose level measurement in vivo, and a continuous glucose monitoring using the fluorescent gel. [Solution] A fluorescent gel for glucose detection having a three-dimensional network structure in which a plurality of tetra-armed polymers having a polyethylene glycol skeleton are crosslinked together at the termini thereof, wherein a fluorochrome unit, said fluorochrome unit being capable of exhibiting a fluorescent response when bound to glucose, is immobilized in the gel structure via a covalent bond.

Inventors:

TAKEUCHI SHOJI (JP)
SAWAYAMA JUN (JP)

Application Number:

PCT/JP2018/001239

Publication Date:

July 26, 2018

Filing Date:

January 17, 2018

Export Citation:

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Assignee:

UNIV TOKYO (JP)

International Classes:

G01N21/78; G01N21/64; C09K11/06

Foreign References:

JP2015059869A

2015-03-30

Other References:

SHIBATA, HIDEAKI ET AL.: "Injectable hydrogel microbeads for fluorescence-based in vivo continuous glucose monitaring", PNAS, vol. 107, no. 42, 19 October 2010 (2010-10-19), pages 17894 - 17898, XP055131431
SAKAI, TAKAMASA: "Correlation Between the Physical Properties and Structure of Tetra-PEG Gels", JOURNAL OF THE SOCIETY OF RUBBER SCIENCE AND TECHNOLOGY, vol. 87, no. 3, 1 January 2014 (2014-01-01), pages 89 - 95, XP055613848, ISSN: 0029-022X, DOI: 10.2324/gomu.87.89
SHIBATA ET AL., PROC. NAT. ACAD. SCI. USA, vol. 107, 2010, pages 17894 - 17898
See also references of EP 3572800A4