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Patent Searching and Data


Title:
FLUORESCENT MICROPARTICLES FOR MAPPING GLUCOSE CONCENTRATION INSIDE THREE-DIMENSIONAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2019/142913
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a novel detection material and detection method which make it possible to conveniently, accurately and non-invasively perform continuous measurement of glucose inside three-dimensional cell tissues such as spheroids. [Solution] Fluorescent microparticles which measure glucose inside three-dimensional cell tissue, and include core particles, the average particle diameter of which is on the order of micrometers, a fluorescent pigment unit which exhibits a fluorescence response by bonding to glucose, and a cell adhesion unit having cell-adhesive molecules, wherein the fluorescent pigment unit and the cell adhesion unit are affixed by covalent bonds to the surface of the core particles.

Inventors:
TAKEUCHI Shoji (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
SAWAYAMA Jun (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
Application Number:
JP2019/001475
Publication Date:
July 25, 2019
Filing Date:
January 18, 2019
Export Citation:
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Assignee:
THE UNIVERSITY OF TOKYO (3-1 Hongo 7-chome, Bunkyo-ku Tokyo, 54, 〒1138654, JP)
International Classes:
G01N21/78; C12Q1/02
Domestic Patent References:
WO2016182022A12016-11-17
Foreign References:
JP2003508186A2003-03-04
JP2004510527A2004-04-08
JP2016503299A2016-02-04
US5849595A1998-12-15
JP2016516729A2016-06-09
JP2014210730A2014-11-13
Other References:
DIBBLE, C.C. ET AL.: "Signal integration by mTORCl coordinates nutrient input with biosynthetic ou tput", NATURE CELL BIOLOGY, 15 June 2013 (2013-06-15), pages 555 - 564, XP055627604
Attorney, Agent or Firm:
ONO Makoto et al. (Anderson Mori & Tomotsune, Otemachi Park Building 1-1-1, Otemach, Chiyoda-ku Tokyo 36, 〒1008136, JP)
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