Title:
FLUORESCENT MICROPARTICLES FOR MAPPING GLUCOSE CONCENTRATION INSIDE THREE-DIMENSIONAL TISSUE
Document Type and Number:
WIPO Patent Application WO/2019/142913
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a novel detection material and detection method which make it possible to conveniently, accurately and non-invasively perform continuous measurement of glucose inside three-dimensional cell tissues such as spheroids. [Solution] Fluorescent microparticles which measure glucose inside three-dimensional cell tissue, and include core particles, the average particle diameter of which is on the order of micrometers, a fluorescent pigment unit which exhibits a fluorescence response by bonding to glucose, and a cell adhesion unit having cell-adhesive molecules, wherein the fluorescent pigment unit and the cell adhesion unit are affixed by covalent bonds to the surface of the core particles.
Inventors:
TAKEUCHI SHOJI (JP)
SAWAYAMA JUN (JP)
SAWAYAMA JUN (JP)
Application Number:
PCT/JP2019/001475
Publication Date:
July 25, 2019
Filing Date:
January 18, 2019
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
G01N21/78; C12Q1/02
Domestic Patent References:
| WO2016182022A1 | 2016-11-17 |
Foreign References:
| JP2003508186A | 2003-03-04 | |||
| JP2004510527A | 2004-04-08 | |||
| JP2016503299A | 2016-02-04 | |||
| US5849595A | 1998-12-15 | |||
| JP2016516729A | 2016-06-09 | |||
| JP2014210730A | 2014-11-13 |
Other References:
DIBBLE, C.C. ET AL.: "Signal integration by mTORCl coordinates nutrient input with biosynthetic ou tput", NATURE CELL BIOLOGY, 15 June 2013 (2013-06-15), pages 555 - 564, XP055627604
Attorney, Agent or Firm:
ONO Makoto et al. (JP)
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