FLUORESCENT PERYLENE DERIVATIVES FOR DIRECT DETECTION OF HEPARIN

Title:

FLUORESCENT PERYLENE DERIVATIVES FOR DIRECT DETECTION OF HEPARIN

Document Type and Number:

WIPO Patent Application WO/2011/020887

Kind Code:

A1

Abstract:

The invention relates to a perylene diimide derivative and to an in vitro method for preparing the same. In addition, the invention relates to a method for detecting heparin in a sample using perylene diimide derivatives, wherein the interaction of the perylene diimide derivative with heparin modulates the intensity of the fluorescent signal of the mixture compared to the solution. The invention also comprises a diagnostic kit for detecting heparin in a sample in vitro, comprising the perylene diimide derivative, as well as the use of the perylene diimide derivative for neutralizing the anticoagulant activity of heparin.

Inventors:

KRAEMER ROLAND (DE)
SZELKE HELGA (DE)
HARENBERG JOB (DE)
POECK ARMIN (DE)

Application Number:

PCT/EP2010/062118

Publication Date:

February 24, 2011

Filing Date:

August 19, 2010

Export Citation:

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Assignee:

UNIV RUPRECHT KARLS HEIDELBERG (DE)
KRAEMER ROLAND (DE)
SZELKE HELGA (DE)
HARENBERG JOB (DE)
POECK ARMIN (DE)

International Classes:

C09B5/62

Foreign References:

US20070004919A1	2007-01-04
US5811307A	1998-09-22
US20020012947A1	2002-01-31

Other References:

FRANCESCHIN, BIOORG.MED.CHEM, vol. 16, 31 December 2007 (2007-12-31), pages 2292 - 2304, XP002573600
MECCA, ORG.BIOMOL.CHEM., vol. 4, 30 August 2006 (2006-08-30), pages 3763 - 3768, XP002573601
SAUCEDA, CHEMBIOCHEM, vol. 8, 23 January 2007 (2007-01-23), pages 391 - 394, XP002573608
DESPOTIS, G.J.; GRAVLEE, G.; FILOS, K.; LEVY, J., ANESTHESIOLOGY, vol. 91, 1999, pages 1122
FRANCESCHIN; M.; LOMBARDO; C.M.; PASCUCCI; E.; D'AMBROSIO; D.; MICHELI; E.; BIANCO,A; ORTAGGI, M; SAVINO, M, BIOORG. MED. CHEM, vol. 16, 2008, pages 2292
WANG, S.; CHANG, Y.-T., COMMUN., vol. 10, 2008, pages 1173
WRIGHT, A.T.; ZHONG, Z.L.; ANSLYN E.V., ANGEW.CHEM.INT.ED., vol. 44, 2005, pages 5679

Attorney, Agent or Firm:

ELBEL, Michaela (Altheimer Eck 13, Munich, DE)

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