Title:
FLUORESCENT PROBE FOR DETECTING ADENOSINE TRIPHOSPHATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/114573
Kind Code:
A1
Abstract:
The present invention relates to a fluorescent probe for detecting adenosine triphosphate and a use thereof, wherein the fluorescent probe can selectively detect adenosine triphosphate without interference from in vivo molecules having a similar structure. In addition, the fluorescent probe according to the present invention has the advantages of having a simple structure and enabling fast mass synthesis. The fluorescent probe according to the present invention has the form of a nanoparticle in an aqueous solution and selectively exhibits fluorescence turn-on properties when bound to adenosine triphosphate, and thus not only overcomes the problems of existing fluorescent probes having a complex structure for detecting adenosine triphosphate and problems due to interference from molecules having a similar structure to adenosine triphosphate, but also has the advantages of high sensitivity and selectivity, fast reaction time, and having wide applicability, such as in the detection of adenosine triphosphate in mitochondria in cells, and thus can be efficiently utilized for selective detection and imaging.
Inventors:
KIM DO KYOUNG (KR)
OH YO HAN (KR)
KIM NA HEE (KR)
OH YO HAN (KR)
KIM NA HEE (KR)
Application Number:
PCT/KR2021/015807
Publication Date:
June 02, 2022
Filing Date:
November 03, 2021
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
IUCF HYU (KR)
IUCF HYU (KR)
International Classes:
C07C211/52; G01N21/64; G01N33/58
Foreign References:
| CN109097027A | 2018-12-28 | |||
| CN105154066A | 2015-12-16 |
Other References:
BIN LI, CHEN TIANHONG, PEÑA JHAIR, XING JINFENG, ZENG LINTAO: "Hyaluronic Acid-Modified Fluorescent Probe for Dual Color Imaging of Living Cell", ACS APPLIED BIO MATERIALS, vol. 3, no. 4, 20 April 2020 (2020-04-20), US , pages 1893 - 1901, XP055933190, ISSN: 2576-6422, DOI: 10.1021/acsabm.9b01065
LOK NATH NEUPANE, EUN-TAEX OH, HEON JOO PARK, KEUN-HYEUNG LEE: "Selective and Sensitive Detection of Heavy Metal Ions in 100% Aqueous Solution and Cells with a Fluorescence Chemosensor Based on Peptide Using Aggregation-Induced Emission", ANALYTICAL CHEMISTRY, vol. 88, no. 6, 15 March 2016 (2016-03-15), US , pages 3333 - 3340, XP055433456, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.5b04892
LI BIN, CHEN TIANHONG, WANG ZHIPENG, GUO ZHIMING, PEÑA JHAIR, ZENG LINTAO, XING JINFENG: "A novel cross-linked nanoparticle with aggregation-induced emission properties for cancer cell imaging", JOURNAL OF MATERIALS CHEMISTRY. B, vol. 8, no. 12, 25 March 2020 (2020-03-25), GB , pages 2431 - 2437, XP055933199, ISSN: 2050-750X, DOI: 10.1039/C9TB02701G
LOK NATH NEUPANE, EUN-TAEX OH, HEON JOO PARK, KEUN-HYEUNG LEE: "Selective and Sensitive Detection of Heavy Metal Ions in 100% Aqueous Solution and Cells with a Fluorescence Chemosensor Based on Peptide Using Aggregation-Induced Emission", ANALYTICAL CHEMISTRY, vol. 88, no. 6, 15 March 2016 (2016-03-15), US , pages 3333 - 3340, XP055433456, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.5b04892
LI BIN, CHEN TIANHONG, WANG ZHIPENG, GUO ZHIMING, PEÑA JHAIR, ZENG LINTAO, XING JINFENG: "A novel cross-linked nanoparticle with aggregation-induced emission properties for cancer cell imaging", JOURNAL OF MATERIALS CHEMISTRY. B, vol. 8, no. 12, 25 March 2020 (2020-03-25), GB , pages 2431 - 2437, XP055933199, ISSN: 2050-750X, DOI: 10.1039/C9TB02701G
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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