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Title:
FLUORESCENT PROBE FOR DETECTING CARBOXYPEPTIDASE ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2019/168199
Kind Code:
A1
Abstract:
[Problem] To provide a fluorescent probe which includes, as the base nucleus, a fluorescent skeleton functioning in the visible light region and which makes carboxypeptidase activity visible with high sensitivity. [Solution] A compound represented by general formula (I) or a salt of the compound.

Inventors:
URANO Yasuteru (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
KAMIYA Mako (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
KAWATANI Minoru (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
Iwaki Hirohisa (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
YAMAMOTO Kyoko (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
KUME Haruki (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
YAMADA Daisuke (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
Application Number:
JP2019/008403
Publication Date:
September 06, 2019
Filing Date:
March 04, 2019
Export Citation:
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Assignee:
THE UNIVERSITY OF TOKYO (3-1 Hongo 7-chome, Bunkyo-ku Tokyo, 54, 〒1138654, JP)
International Classes:
C09B29/01; C12Q1/37; G01N33/573; C07D311/90; C07D493/10
Foreign References:
US20060003383A12006-01-05
Other References:
MOCK, WILLIAM L. ET AL.: "Arazoformyl peptide surrogates as spectrophotometric kinetic asay substrates for carboxypeptidase A", ANALYTICAL BIOCHEMISTRY, vol. 239, no. 2, 1996, pages 218 - 222, XP002196534, ISSN: 0960-894X, doi:10.1006/abio.1996.0318
MOCK, WILLIAM L. ET AL.: "Catalytic activity of carboxypeptidase B and of carboxypeptidase Y with anisylazoformyl substrates", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, no. 2, 1999, pages 187 - 192, XP004152597, ISSN: 0960-894X, doi:10.1016/S0960-894X(98)00715-X
KURIKI, YUGO ET AL.: "Establishment of molecular desigh strategy to obtain activatable fluorescent probes for carboxypeptidases", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 140, no. 5, 2018, pages 1767 - 1773, XP055633935, ISSN: 1520-5126
1 February 2018 (2018-02-01), Retrieved from the Internet
Attorney, Agent or Firm:
ONO Makoto et al. (Anderson Mori & Tomotsune, Otemachi Park Building 1-1-1, Otemach, Chiyoda-ku Tokyo 36, 〒1008136, JP)
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