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Title:
FLUORESCENT PROTEIN
Document Type and Number:
WIPO Patent Application WO/2016/182019
Kind Code:
A1
Abstract:
Provided is a light switching type fluorescent protein in which the on/off states of the fluorescence and all fluorescence excitation wavelengths are independent, wherein a recovering rate from a non-fluorescent state to a fluorescent state is enhanced due to thermal equilibration. In an embodiment, a fluorescent protein having an amino acid sequence in which at least S208G mutation is introduced into SEQ ID NO: 1 is provided. In another embodiment, a fluorescent protein having an amino acid sequence in which at least three mutations, i.e., I47V, M153T, and S208G are introduced into SEQ ID NO: 1 is provided. In another embodiment, a fluorescent protein having an amino acid sequence in which at least five mutations, i.e., I47V, T59S, M153T, S208G, and M233T are introduced into SEQ ID NO: 1 is provided. In another embodiment, a fluorescent protein having an amino acid sequence in which at least six mutations, i.e., I47V, T59S, M69Q, M153T, S208G, and M233T are introduced into SEQ ID NO: 1 is provided.

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Inventors:
NAGAI TAKEHARU (JP)
TAKAUCHI HIROKI (JP)
ARAI YOSHIYUKI (JP)
NAKANO MASAHIRO (JP)
Application Number:
PCT/JP2016/064132
Publication Date:
November 17, 2016
Filing Date:
May 12, 2016
Export Citation:
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Assignee:
UNIV OSAKA (JP)
International Classes:
C07K14/435; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; G01N21/64
Domestic Patent References:
WO2012045733A12012-04-12
WO2015037674A12015-03-19
Other References:
JENSEN NA ET AL.: "Coordinate-targeted and coordinate-stochastic super-resolution microscopy with the reversibly switchable fluorescent protein Dreiklang", CHEMPHYSCHEM., vol. 15, no. 4, 2014, pages 756 - 762, XP055329123, ISSN: 1439-4235
BRAKEMANN T ET AL.: "A reversibly photoswitchable GFP-like protein with fluorescence excitation decoupled from switching", NAT. BIOTECHNOL., vol. 29, no. 10, 2011, pages 942 - 947, XP055016082, ISSN: 1087-0156
Attorney, Agent or Firm:
IKEUCHI SATO & PARTNER PATENT ATTORNEYS (JP)
Patent business corporation Ikeuchi and Sato and partners (JP)
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