Title:
FLUORESCENT RED-EMISSIVE COMPOUNDS FOR CELLULAR ORGANELLE IMAGING
Document Type and Number:
WIPO Patent Application WO/2020/253756
Kind Code:
A1
Abstract:
Small molecule fluorescent compounds having aggregation-induced emission (AIE) characteristics are disclosed. The compounds exhibit red to near-infrared solid-state emission, large Stokes shift, high fluorescence quantum yield and good two-photon absorption cross section. The compounds can provide specific organelle staining in live cells and deep tissues. The compounds also exhibit high biocompatibility and high photostability under one-photon and two-photon continuous irradiation.
Inventors:
TANG BENZHONG (CN)
ALAM PARVEJ (CN)
NIU GUANGLE (CN)
HE WE (CN)
LEUNG NELSON LIK CHING (CN)
ALAM PARVEJ (CN)
NIU GUANGLE (CN)
HE WE (CN)
LEUNG NELSON LIK CHING (CN)
Application Number:
PCT/CN2020/096689
Publication Date:
December 24, 2020
Filing Date:
June 18, 2020
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
C07D213/20; C09K11/06; C07D213/24
Domestic Patent References:
| WO2017080449A1 | 2017-05-18 |
Foreign References:
| CN108530419A | 2018-09-14 |
Other References:
GUANGLE NIU; ZHENG XIULI; ZHAO ZHENG; ZHANG HAOKE; WANG JIANGUO; HE XUEWEN; CHEN YUNCONG; SHI XIUJUAN; MA CHAO; KWOK RYAN T K; LAM: "Functionalized Acrylonitriles with Aggregation-Induced Emission: Structure Tuning by Simple Reaction-Condition Variation， Efficient Red Emission， and Two-Photon Bioimaging", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 141, no. 38, 22 August 2019 (2019-08-22), pages 15111 - 15120, XP055719635, ISSN: 0002-7863, DOI: 10.1021/jacs.9b06196
PARVEJ ALAM, HE WEI, LEUNG NELSON L. C., MA CHAO, KWOK RYAN T. K., LAM JACKY W. Y., SUNG HERMAN H. Y., WILLIAMS IAN D., WONG KAM S: "Red AIE-Active Fluorescent Probes with Tunable Organelle-Specific Targeting", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 10, 20 January 2020 (2020-01-20), pages 1 - 9, XP055766989, ISSN: 1616-301X, DOI: 10.1002/adfm.201909268
XIAOJING LI, HU WENRUI, WANG YUXIANG, QUAN YIWU, CHENG YIXIANG: "Strong CPL of Achiral AIE-active Dyes Induced by Supramolecular Self-assemble in Chiral Nematic Liquid Crystals (AIE-N-LCs)", CHEMICAL COMMUNICATIONS, vol. 55, no. 35, 5 April 2019 (2019-04-05), pages 5179 - 5182, XP055766995
ALEXANDRE FAURIE, GROLLEAU JÉRÉMIE, GOHIER FRÉDÉRIC, ALLAIN MAGALI, LEGOUPY STÉPHANIE, FRÈRE PIERRE: "Toward Sustainable Organic Semiconductors from a Broad Palette of Green Reactions", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, no. 19, 18 May 2017 (2017-05-18), pages 2707 - 2714, XP055767000, ISSN: 1434-193X, DOI: 10.1002/ejoc.201700317
BYEONG KWAN AN , SOON-KI KWON , SANG-DON JUNG , SOO YOUNG PARK: "Enhanced Emission and Its Switching in Fluorescent Organic Nanoparticles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, no. 28, 1 January 2002 (2002-01-01), pages 14410 - 14415, XP009052989, ISSN: 0002-7863, DOI: 10.1021/ja0269082
BYEONG-KWAN AN, KWON SOON-KI, PARK SOO YOUNG: "Photopatterned Arrays of Fluorescent Organic Nanoparticles", ANGEW. CHEM. INT. ED., vol. 46, no. 12, 2 March 2007 (2007-03-02), pages 1978 - 1982, XP055767008, ISSN: 1433-7851, DOI: 10.1002/anie.200604209
PARVEJ ALAM, HE WEI, LEUNG NELSON L. C., MA CHAO, KWOK RYAN T. K., LAM JACKY W. Y., SUNG HERMAN H. Y., WILLIAMS IAN D., WONG KAM S: "Red AIE-Active Fluorescent Probes with Tunable Organelle-Specific Targeting", ADVANCED FUNCTIONAL MATERIALS, vol. 30, no. 10, 20 January 2020 (2020-01-20), pages 1 - 9, XP055766989, ISSN: 1616-301X, DOI: 10.1002/adfm.201909268
XIAOJING LI, HU WENRUI, WANG YUXIANG, QUAN YIWU, CHENG YIXIANG: "Strong CPL of Achiral AIE-active Dyes Induced by Supramolecular Self-assemble in Chiral Nematic Liquid Crystals (AIE-N-LCs)", CHEMICAL COMMUNICATIONS, vol. 55, no. 35, 5 April 2019 (2019-04-05), pages 5179 - 5182, XP055766995
ALEXANDRE FAURIE, GROLLEAU JÉRÉMIE, GOHIER FRÉDÉRIC, ALLAIN MAGALI, LEGOUPY STÉPHANIE, FRÈRE PIERRE: "Toward Sustainable Organic Semiconductors from a Broad Palette of Green Reactions", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, no. 19, 18 May 2017 (2017-05-18), pages 2707 - 2714, XP055767000, ISSN: 1434-193X, DOI: 10.1002/ejoc.201700317
BYEONG KWAN AN , SOON-KI KWON , SANG-DON JUNG , SOO YOUNG PARK: "Enhanced Emission and Its Switching in Fluorescent Organic Nanoparticles", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 124, no. 28, 1 January 2002 (2002-01-01), pages 14410 - 14415, XP009052989, ISSN: 0002-7863, DOI: 10.1021/ja0269082
BYEONG-KWAN AN, KWON SOON-KI, PARK SOO YOUNG: "Photopatterned Arrays of Fluorescent Organic Nanoparticles", ANGEW. CHEM. INT. ED., vol. 46, no. 12, 2 March 2007 (2007-03-02), pages 1978 - 1982, XP055767008, ISSN: 1433-7851, DOI: 10.1002/anie.200604209
Attorney, Agent or Firm:
TEE&HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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