Title:
FLUORINATED ORGANIC COMPOUND PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2019/189862
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a fluorinated organic compound production method that makes it possible to easily separate and recover iodosylbenzene derivatives. A fluorinated organic compound production method that includes: a step A in which an organic compound (1) is fluorinated by reaction with a fluorine source (3) in the presence of a hypervalent iodo aromatic ring compound (2a) or in the presence of an iodo aromatic ring compound (2b) and an oxidizing agent (2bo) (the fluorine source (3) being a fluorine source (3a) that is represented by the formula MFn (in which M is H, a group 1 metal, or a group 2 metal, and n is 1 or 2)); and a step B in which, after step A has begun, iodo aromatic ring compounds are separated from a reaction liquid.
Inventors:
HIGASHI MASAHIRO (JP)
KISHIKAWA YOSUKE (JP)
KITAMURA TSUGIO (JP)
KISHIKAWA YOSUKE (JP)
KITAMURA TSUGIO (JP)
Application Number:
PCT/JP2019/014278
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
UNIV SAGA (JP)
UNIV SAGA (JP)
International Classes:
C07C67/307; C07C69/757
Foreign References:
| JP2015157788A | 2015-09-03 | |||
| JP2014234355A | 2014-12-15 | |||
| JP2003113131A | 2003-04-18 | |||
| JP2015157788A | 2015-09-03 |
Other References:
KITAMURA, T. ET AL.: "A Practical and Convenient Fluorination of 1,3-Dicarbonyl Compounds Using Aqueous HF in the Presence of Iodosylbenzene", ORGANIC LETTERS, vol. 13, no. 9, 2011, pages 2392 - 2394, XP002688137, ISSN: 1523-7052, doi:10.1021/OL200632D
KITAMURA, T. ET AL.: "Facile synthesis of 2-fluoro-1, 3-dicarbonyl compounds with aqueous hydrofluoric acid mediated by iodosylarenes", SYNTHESIS, vol. 45, no. 22, 29 August 2013 (2013-08-29), pages 3125 - 3130, XP055639163, ISSN: 0039-7881
KITAMURA, T. ET AL.: "A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine", SYNTHESIS, vol. 47, no. 20, 12 August 2015 (2015-08-12), pages 3241 - 3245, XP055639169, ISSN: 1437-210X
NASH, T. J. ET AL.: "Apparent Electrophilic Fluorination of 1,3-Dicarbonyl Compounds Using Nucleophilic Fluoride Mediated by PhI(OAc)2", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2015, no. 17, 5 May 2015 (2015-05-05) - June 2015 (2015-06-01), pages 3779 - 3786, XP055639172, ISSN: 1099-0690
YAMADA, Y. ET AL.: "Syntheses and reactions of functional polymers. LXIII . Syntheses of phenyl polystyryliodonium salts", MAKROMOLEKULARE CHEMIE, vol. 152, 5 May 1971 (1971-05-05) - 18 February 1972 (1972-02-18), pages 153 - 162, XP055639177, ISSN: 0025-116X
See also references of EP 3778548A4
KITAMURA, T. ET AL.: "Facile synthesis of 2-fluoro-1, 3-dicarbonyl compounds with aqueous hydrofluoric acid mediated by iodosylarenes", SYNTHESIS, vol. 45, no. 22, 29 August 2013 (2013-08-29), pages 3125 - 3130, XP055639163, ISSN: 0039-7881
KITAMURA, T. ET AL.: "A Convenient Synthesis of 2-Fluoro- and 2-Chloromalonic Esters Mediated by Hypervalent Iodine", SYNTHESIS, vol. 47, no. 20, 12 August 2015 (2015-08-12), pages 3241 - 3245, XP055639169, ISSN: 1437-210X
NASH, T. J. ET AL.: "Apparent Electrophilic Fluorination of 1,3-Dicarbonyl Compounds Using Nucleophilic Fluoride Mediated by PhI(OAc)2", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2015, no. 17, 5 May 2015 (2015-05-05) - June 2015 (2015-06-01), pages 3779 - 3786, XP055639172, ISSN: 1099-0690
YAMADA, Y. ET AL.: "Syntheses and reactions of functional polymers. LXIII . Syntheses of phenyl polystyryliodonium salts", MAKROMOLEKULARE CHEMIE, vol. 152, 5 May 1971 (1971-05-05) - 18 February 1972 (1972-02-18), pages 153 - 162, XP055639177, ISSN: 0025-116X
See also references of EP 3778548A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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