Title:
FLUORINATED PROSTAGLANDIN DERIVATIVES AND MEDICINES
Document Type and Number:
WIPO Patent Application WO/1998/012175
Kind Code:
A1
Abstract:
Fluorinated prostaglandin derivatives represented by general formula (1) or salts thereof; and medicines containing the same as the active ingredient, particularly ones to be used for preventing or treating eye diseases. In said formula A represents vinylene, ethylene, ethynylene, etc.; R?1� represents aryloxyalkyl, alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl, etc.; R?2� and R?3� represent each hydrogen, acyl, etc.; Z represents -OR?4�, -NHCOR?5�, -NHSO�2?R?6�, -SR?7� (wherein R?4�, R?5�, R?6� and R?7� represent each hydrogen, alkyl, etc.); and the combination of the solid line with the broken line represents a single bond, a <u>cis</u> double bond or a <u>trans</u> double bond. The medicines are excellent as a medicine for eye diseases with high pharmacological effects and low side effects.
Inventors:
SHIRASAWA EIICHI (JP)
KAGEYAMA MASAAKI (JP)
MORI NOBUAKI (JP)
SAKATA KAZUHISA (JP)
NAKANO TAKASHI (JP)
MATSUMURA YASUSHI (JP)
MORIZAWA YOSHITOMI (JP)
KAGEYAMA MASAAKI (JP)
MORI NOBUAKI (JP)
SAKATA KAZUHISA (JP)
NAKANO TAKASHI (JP)
MATSUMURA YASUSHI (JP)
MORIZAWA YOSHITOMI (JP)
Application Number:
PCT/JP1997/003236
Publication Date:
March 26, 1998
Filing Date:
September 12, 1997
Export Citation:
Assignee:
ASAHI GLASS CO LTD (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
SHIRASAWA EIICHI (JP)
KAGEYAMA MASAAKI (JP)
MORI NOBUAKI (JP)
SAKATA KAZUHISA (JP)
NAKANO TAKASHI (JP)
MATSUMURA YASUSHI (JP)
MORIZAWA YOSHITOMI (JP)
SANTEN PHARMACEUTICAL CO LTD (JP)
SHIRASAWA EIICHI (JP)
KAGEYAMA MASAAKI (JP)
MORI NOBUAKI (JP)
SAKATA KAZUHISA (JP)
NAKANO TAKASHI (JP)
MATSUMURA YASUSHI (JP)
MORIZAWA YOSHITOMI (JP)
International Classes:
C07C405/00; C07D307/935; C07D313/00; (IPC1-7): C07C405/00; C07D313/00; A61K31/557; A61K31/335
Foreign References:
| JPH03501025A | 1991-03-07 | |||
| JPH07165703A | 1995-06-27 |
Other References:
BIOORG. KHIM., Vol. 7, No. 3, (1981), BEZUGLOV V.V. et al., "Synthesis of Tritium-Labeled 15-Fluoro-15-Deoxyprostaglandins A2, B2 and F2Alpha", pages 448-454.
See also references of EP 0930296A4
See also references of EP 0930296A4
Attorney, Agent or Firm:
Ogawa, Toshiharu (38 Kanda-Higashimatsushitach, Chiyoda-ku Tokyo 101, JP)
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