Title:
FLUORINATED PYRIMIDINE COMPOUND AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2020/116296
Kind Code:
A1
Abstract:
Provided are: a novel fluorinated pyrimidine compound having a substituent at position 4 and position 6, and a pyridine ring structure or a diazine ring structure at position 2; and a production method that enables easy production of the fluorinated pyrimidine compound. This fluorinated pyrimidine compound is represented by general formula (1), (2), (3), (4), (5), or (6). (In general formulas (1)-(6), R represents a hydrocarbon group having 1-12 carbon atoms, X and Y each independently represent a hydrogen atom, a halogen atom, a hydrocarbon group having 1-10 carbon atoms, -CnF2n+1 (n represents an integer of 1-10), a nitro group, a boronic acid group, -OA1, -SOmA1 (m represents an integer of 0-3), -NA1A2, -COOA1, or -CONA1A2, and A1 and A2 each independently represent a hydrogen atom or a hydrocarbon group having 1-10 carbon atoms.)
Inventors:
SEINO JUNYA (JP)
AOTSU RIE (JP)
KOKIN KEISUKE (JP)
AOTSU RIE (JP)
KOKIN KEISUKE (JP)
Application Number:
PCT/JP2019/046489
Publication Date:
June 11, 2020
Filing Date:
November 28, 2019
Export Citation:
Assignee:
UNIMATEC CO LTD (JP)
International Classes:
C07D401/04; C07D239/34; C07D403/04; C07B61/00
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Foreign References:
| JP2013515688A | 2013-05-09 | |||
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Other References:
INOUYE, Y. ET AL.: "A Facile One-pot Preparation of 2-Methyl- and 2-Phenyl-4- fluoro-5-trifluoromethyl-6-methoxypyrimidine from Methyl 2-hydryl-2-(F- methyl)-F-propyl Ether", JOURNAL OF FLUORINE CHEMISTRY, vol. 27, no. 2, February 1985 (1985-02-01), pages 231 - 236, XP055717031
ORGANIC LETTERS, vol. 57, 2018, pages 6926 - 6929
TETRAHEDRON, vol. 72, 2016, pages 3250 - 3255
ACS CATALYSIS, vol. 8, 2018, pages 2839 - 2843
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, 2018, pages 6926 - 6929
See also references of EP 3892617A4
ORGANIC LETTERS, vol. 57, 2018, pages 6926 - 6929
TETRAHEDRON, vol. 72, 2016, pages 3250 - 3255
ACS CATALYSIS, vol. 8, 2018, pages 2839 - 2843
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 57, 2018, pages 6926 - 6929
See also references of EP 3892617A4
Attorney, Agent or Firm:
EINSEL Felix-Reinhard et al. (JP)
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