Title:
FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/188590
Kind Code:
A1
Abstract:
Fluorine-substituted indazole compounds, pharmaceutical compositions containing these compounds and uses thereof. The compounds and pharmaceutical compositions can be used as soluble guanylate cyclase simulators.
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Inventors:
ZUO YINGLIN (CN)
WANG XIAOJUN (CN)
YANG CHUANWEN (CN)
WANG JIANCHENG (CN)
CAO SHENGTIAN (CN)
WU FANGYUAN (CN)
ZHANG YINGJUN (CN)
GOLDMANN SIEGFRIED (CN)
WANG XIAOJUN (CN)
YANG CHUANWEN (CN)
WANG JIANCHENG (CN)
CAO SHENGTIAN (CN)
WU FANGYUAN (CN)
ZHANG YINGJUN (CN)
GOLDMANN SIEGFRIED (CN)
Application Number:
PCT/CN2018/082522
Publication Date:
October 18, 2018
Filing Date:
April 10, 2018
Export Citation:
Assignee:
SUNSHINE LAKE PHARMA CO LTD (CN)
International Classes:
A61K31/416; C07D401/14; A61K31/506; A61P9/00; C07D231/54; C07D401/04
Domestic Patent References:
| WO2011149921A1 | 2011-12-01 |
Foreign References:
| CN1692102A | 2005-11-02 | |||
| CN104853757A | 2015-08-19 | |||
| CN104822377A | 2015-08-05 | |||
| CN103748076A | 2014-04-23 | |||
| CN1512987A | 2004-07-14 | |||
| CA2346698A1 | 2000-04-20 |
Other References:
ELIEL, E.WILEN, S.: "Stereochemistry of Organic Compounds", 1994, JOHN WILEY & SONS, INC.
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
MCGRAW-HILL: "Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
BIOCHEM, vol. 11, 1972, pages 942 - 944
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS& WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
INACTIVE INGREDIENT GUIDE, 1996
"Handbook of Pharmaceutical Additives", 2002, SYNAPSE INFORMATION RESOURCES, INC.
See also references of EP 3609883A4
THOMAS SORRELL: "Organic Chemistry", 1999, UNIVERSITY SCIENCE BOOKS
SMITH ET AL.: "March's Advanced Organic Chemistry", 2007, JOHN WILEY & SONS
MCGRAW-HILL: "Dictionary of Chemical Terms", 1984, MCGRAW-HILL BOOK COMPANY
T. HIGUCHIV. STELLA: "Pro-drugs as Novel Delivery Systems", A.C.S. SYMPOSIUM SERIES, vol. 14
"Bioreversible Carriers in Drug Design", 1987, AMERICAN PHARMACEUTICAL ASSOCIATION AND PERGAMON PRESS
J. RAUTIO ET AL.: "Prodrugs: Design and Clinical Applications", NATURE REVIEW DRUG DISCOVERY, vol. 7, 2008, pages 255 - 270, XP055227338, DOI: 10.1038/nrd2468
S. J. HECKER ET AL.: "Prodrugs of Phosphates and Phosphonates", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, 2008, pages 2328 - 2345, XP008148502, DOI: 10.1021/jm701260b
J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 1 - 19
L. W. DEADY, SYN. COMM., vol. 7, 1977, pages 509 - 514
BIOCHEM, vol. 11, 1972, pages 942 - 944
"Remington: The Science and Practice of Pharmacy", 2005, LIPPINCOTT WILLIAMS& WILKINS
"Encyclopedia of Pharmaceutical Technology", 1988, MARCEL DEKKER
INACTIVE INGREDIENT GUIDE, 1996
"Handbook of Pharmaceutical Additives", 2002, SYNAPSE INFORMATION RESOURCES, INC.
See also references of EP 3609883A4
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