Title:
FLUOROALKYLOXY-CONTAINING COMBRETASTATIN DERIVATIVES, PREPARATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2007/140662
Kind Code:
A1
Abstract:
Combretastatin derivatives of formula (I) , preparation and use thereof are
disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine
atoms , R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate
or amino acid side chain. Said derivatives have a capability to inhibit the polymerization
of microtubules and are useful in treatment against tumor and neovascularization.
Inventors:
SHEN WEIPING (CN)
WANG JIANPING (CN)
WANG JIANGUO (CN)
JIN HONGMEI (CN)
QIAN FENG (CN)
WANG FEI (CN)
WANG JIANPING (CN)
WANG JIANGUO (CN)
JIN HONGMEI (CN)
QIAN FENG (CN)
WANG FEI (CN)
Application Number:
PCT/CN2006/003149
Publication Date:
December 13, 2007
Filing Date:
November 22, 2006
Export Citation:
Assignee:
ZHEJIANG DADE PHARMACEUTICAL G (CN)
SHEN WEIPING (CN)
WANG JIANPING (CN)
WANG JIANGUO (CN)
JIN HONGMEI (CN)
QIAN FENG (CN)
WANG FEI (CN)
SHEN WEIPING (CN)
WANG JIANPING (CN)
WANG JIANGUO (CN)
JIN HONGMEI (CN)
QIAN FENG (CN)
WANG FEI (CN)
International Classes:
A61K31/09; C07C43/23; A61K31/136; A61K31/16; A61K31/661; A61P35/00; C07C43/225; C07C217/84; C07C237/04; C07F9/12
Domestic Patent References:
| WO2006036743A2 | 2006-04-06 | |||
| WO1999035150A1 | 1999-07-15 | |||
| WO2002058535A2 | 2002-08-01 |
Foreign References:
| GB2403949A | 2005-01-19 | |||
| US5561122A | 1996-10-01 | |||
| US6773702B2 | 2004-08-10 | |||
| US6919324B2 | 2005-07-19 |
Other References:
LAWRENCE N.J. ET AL.: "Synthesis and anticancer activity of fluorinated analogues of cembretastatin A-4", JOURNAL OF FLUORINE CHEMISTRY, no. 123, 2003, pages 101 - 108, XP004456427
THORPE PE., CLIN CANCER RES., vol. 10, no. 2, 15 January 2004 (2004-01-15), pages 415 - 27
WEST CM; PRICE P., ANTICANCER DRUGS, vol. 15, no. 3, March 2004 (2004-03-01), pages 179 - 87
YOUNG SL; CHAPLIN DJ., EXPERT OPIN INVESTIG DRUGS, vol. 13, no. 9, September 2004 (2004-09-01), pages 1171 - 82
PETTIT,G.R. ET AL., ANTI-CANCER DRUG DESIGN, vol. 13, 1998, pages 183 - 191
PETTIT,G.R. ET AL., J.MEDCHEM., vol. 46, 2002, pages 525 - 31
THORPE PE., CLIN CANCER RES., vol. 10, no. 2, 15 January 2004 (2004-01-15), pages 415 - 27
WEST CM; PRICE P., ANTICANCER DRUGS, vol. 15, no. 3, March 2004 (2004-03-01), pages 179 - 87
YOUNG SL; CHAPLIN DJ., EXPERT OPIN INVESTIG DRUGS, vol. 13, no. 9, September 2004 (2004-09-01), pages 1171 - 82
PETTIT,G.R. ET AL., ANTI-CANCER DRUG DESIGN, vol. 13, 1998, pages 183 - 191
PETTIT,G.R. ET AL., J.MEDCHEM., vol. 46, 2002, pages 525 - 31
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC. (435 Guiping Road, Shanghai 3, CN)
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