Title:
FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL
Document Type and Number:
WIPO Patent Application WO/2010/017343
Kind Code:
A3
Abstract:
The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.
Inventors:
KALOFONOS ISABEL (US)
STAHLY G PATRICK (US)
MARTIN-DOYLE WILLIAM (US)
KALOFONOS DIMITRIS (US)
STULTS JEFFREY S (US)
HANKO JASON A (US)
SHIPPLETT REX A (US)
STAHLY G PATRICK (US)
MARTIN-DOYLE WILLIAM (US)
KALOFONOS DIMITRIS (US)
STULTS JEFFREY S (US)
HANKO JASON A (US)
SHIPPLETT REX A (US)
Application Number:
PCT/US2009/052925
Publication Date:
May 14, 2010
Filing Date:
August 06, 2009
Export Citation:
Assignee:
BIONEVIA PHARMACEUTICALS INC (US)
KALOFONOS ISABEL (US)
STAHLY G PATRICK (US)
MARTIN-DOYLE WILLIAM (US)
KALOFONOS DIMITRIS (US)
STULTS JEFFREY S (US)
HANKO JASON A (US)
SHIPPLETT REX A (US)
KALOFONOS ISABEL (US)
STAHLY G PATRICK (US)
MARTIN-DOYLE WILLIAM (US)
KALOFONOS DIMITRIS (US)
STULTS JEFFREY S (US)
HANKO JASON A (US)
SHIPPLETT REX A (US)
International Classes:
C07D213/75; A61K31/44; A61P25/00; A61P25/04; C07D211/36
Domestic Patent References:
| WO2004078163A2 | 2004-09-16 | |||
| WO2008007117A1 | 2008-01-17 | |||
| WO2005058319A1 | 2005-06-30 |
Foreign References:
| US4481205A | 1984-11-06 |
Other References:
See also references of EP 2361247A4
Attorney, Agent or Firm:
LINDEMAN, Jeffrey, A. (PLLC8200 Greensboro Drive, Suite 1020, McLean VA, US)
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