Title:
FO-6979 SUBSTANCES AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2002/074792
Kind Code:
A1
Abstract:
(Beauveria) sp. FO-6979 (FERM BP-6681), which belongs to the genus Beauveria and is capable of producing FO-6979-M0, -M1, -M2, -M3 and -M4 substances, is cultured in a medium to thereby accumulate the FO-6979-M0, -M1, -M2, -M3 and -M4 substances in the liquid culture medium. Then the FO-6979-M0, -M1, -M2, -M3 and -M4 substances are collected from the culture medium. The substances thus obtained are less toxic, specifically inhibit acyl-Coenzyme A: cholesterol acyltransferase, and inhibit the formation of oil droplets in macrophages. Owing to these characteristics, the above substances are useful in preventing and treating human diseases caused by cholesterol accumulation.
Inventors:
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
TOMODA HIROSHI (JP)
Application Number:
PCT/JP2002/002590
Publication Date:
September 26, 2002
Filing Date:
March 19, 2002
Export Citation:
Assignee:
GAKKOU HOUJIN KITASATO GAKUEN (JP)
JAPAN SOC PROMOTION MACH IND (JP)
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
JAPAN SOC PROMOTION MACH IND (JP)
OMURA SATOSHI (JP)
TOMODA HIROSHI (JP)
International Classes:
C12N9/99; A61K31/395; A61K38/00; A61K38/55; A61P3/06; A61P9/10; C07D273/00; C07K5/083; C07K5/087; C07K19/00; C12N1/14; C12P17/14; C12P21/02; C12R1/645; (IPC1-7): C07K5/083; C07K5/087; C12N1/14; C12P21/02
Foreign References:
| JPH11279195A | 1999-10-12 |
Other References:
KUZMA M. ET AL.: "Sequencing of new beauverolides by high-performance liquid chromatography and mass spectrometry", J. MASS. SPECTROM., vol. 36, September 2001 (2001-09-01), pages 1108 - 1115, XP002953511
MOCHIZUKI K. ET AL.: "The structures of bioactive cyclodepsipeptides, beauveriolides I and II, metabolites of entomopathogenic fungi beauveria sp.", BULL. CHEM. SOC. JPN., vol. 66, 1993, pages 3041 - 3046, XP002953512
NAMATAME I. ET AL.: "Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produces by beauveria sp. FO-6979", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 1, 1999, pages 1 - 6, XP002953513
JEGOROV A. ET AL.: "Beauverolides L and La from beauveria tenella and paecilomyces fumosoroseus", PHYTOCHEMISTRY, vol. 37, no. 5, 1994, pages 1301 - 1303, XP002953514
ELSWORTH J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana. Part 2. Beauverolides A to F and their relationship to isarolide", J. CHEM. SOC., PERKIN TRANS. 1, vol. 8, 1980, pages 1795 - 1799, XP002953515
GROVE J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana. Part 3. The isolation of beauverolides Ba, Ca, Ja and Ka", J. CHEM. SOC., PERKIN TRANS. 1, vol. 12, 1980, pages 2878 - 2880, XP002953516
ELSWORTH J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana Bals. Part 1. Beauverolides H and I", J. CHEM. SOC., PERKIN TRANS. 1, vol. 3, 1977, pages 270 - 273, XP002953517
MOCHIZUKI K. ET AL.: "The structures of bioactive cyclodepsipeptides, beauveriolides I and II, metabolites of entomopathogenic fungi beauveria sp.", BULL. CHEM. SOC. JPN., vol. 66, 1993, pages 3041 - 3046, XP002953512
NAMATAME I. ET AL.: "Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produces by beauveria sp. FO-6979", THE JOURNAL OF ANTIBIOTICS, vol. 52, no. 1, 1999, pages 1 - 6, XP002953513
JEGOROV A. ET AL.: "Beauverolides L and La from beauveria tenella and paecilomyces fumosoroseus", PHYTOCHEMISTRY, vol. 37, no. 5, 1994, pages 1301 - 1303, XP002953514
ELSWORTH J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana. Part 2. Beauverolides A to F and their relationship to isarolide", J. CHEM. SOC., PERKIN TRANS. 1, vol. 8, 1980, pages 1795 - 1799, XP002953515
GROVE J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana. Part 3. The isolation of beauverolides Ba, Ca, Ja and Ka", J. CHEM. SOC., PERKIN TRANS. 1, vol. 12, 1980, pages 2878 - 2880, XP002953516
ELSWORTH J.F. ET AL.: "Cyclodepsipeptides from beauveria bassiana Bals. Part 1. Beauverolides H and I", J. CHEM. SOC., PERKIN TRANS. 1, vol. 3, 1977, pages 270 - 273, XP002953517
Attorney, Agent or Firm:
Kobayashi, Kazunori (25-1 Kitaotsuka 2-chom, Toshima-ku Tokyo, JP)
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