Title:
FOCAL ADHESION KINASE SPLICING ISOMER AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/273422
Kind Code:
A1
Abstract:
The present invention provides a focal adhesion kinase splicing isomer and an application thereof, specifically provides an application of a reagent for detecting a focal adhesion kinase splicing isomer in preparing a diagnostic agent for diagnosing small-cell carcinoma, and also provides an application of the focal adhesion kinase splicing isomer as a target in screening and/or preparing a drug for treating the small-cell carcinoma.
Inventors:
ZHOU GUANGBIAO (CN)
WANG GUIZHEN (CN)
XIE DAWEI (CN)
SUN BEIBEI (CN)
WANG ZHENG (CN)
WANG GUIZHEN (CN)
XIE DAWEI (CN)
SUN BEIBEI (CN)
WANG ZHENG (CN)
Application Number:
PCT/CN2022/081428
Publication Date:
January 05, 2023
Filing Date:
March 17, 2022
Export Citation:
Assignee:
CANCER HOSPITAL CAMS (CN)
International Classes:
C12Q1/6886; A61K45/00; A61P35/00; G01N33/573; G01N33/574
Domestic Patent References:
| WO2020163553A1 | 2020-08-13 |
Foreign References:
| CN113186296A | 2021-07-30 | |||
| US20080206800A1 | 2008-08-28 | |||
| CN109112213A | 2019-01-01 |
Other References:
ABOUBAKAR NANA FRANK, HOTON DELPHINE, AMBROISE JÉRÔME, LECOCQ MARYLÈNE, VANDERPUTTEN MARIE, SIBILLE YVES, VANAUDENAERDE BART, PILE: "Increased Expression and Activation of FAK in Small-Cell Lung Cancer Compared to Non-Small-Cell Lung Cancer", CANCERS, vol. 11, no. 10, 1 January 2019 (2019-01-01), pages 1 - 18, XP093020165, DOI: 10.3390/cancers11101526
ZHOU BO, WANG GUI-ZHEN, WEN ZHE-SHENG, ZHOU YONG-CHUN, HUANG YUN-CHAO, CHEN YING, ZHOU GUANG-BIAO: "Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non–Small Cell Lung Cancer", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 110, no. 2, 1 February 2018 (2018-02-01), GB , pages 195 - 204, XP093020172, ISSN: 0027-8874, DOI: 10.1093/jnci/djx157
LING YAO , XIN-MIN ZHENG: "Progress in research of isoforms and mutations of FAK", CHEMISTRY OF LIFE, vol. 29, no. 1, 15 February 2009 (2009-02-15), pages 26 - 28, XP093020183, ISSN: 1000-1336, DOI: 10.13488/j.ismbx.2009.01.004
CHRISTEL DEVAUD; ANNE‐FRANÇOISE TILKIN‐MARIAMÉ; ALIX VIGNOLLE‐VIDONI; PHILIPPINE SOULERES; ALEXANDRE DENADAI‐SOUZA; CORINNE ROLLAN: "FAK alternative splice mRNA variants expression pattern in colorectal cancer", INTERNATIONAL JOURNAL OF CANCER, vol. 145, no. 2, 14 February 2019 (2019-02-14), US , pages 494 - 502, XP071290793, ISSN: 0020-7136, DOI: 10.1002/ijc.32120
FANG XUQIAN, LIU XIANGFAN, YAO LING, CHEN CHANGQIANG, LIN JIAFEI, NI PEIHUA, ZHENG XINMIN, FAN QISHI: "New Insights into FAK Phosphorylation Based on a FAT Domain-Defective Mutation", PLOS ONE, vol. 9, no. 9, 16 September 2014 (2014-09-16), pages 1 - 10, XP093020180, DOI: 10.1371/journal.pone.0107134
ZHOU BO, WANG GUI-ZHEN, WEN ZHE-SHENG, ZHOU YONG-CHUN, HUANG YUN-CHAO, CHEN YING, ZHOU GUANG-BIAO: "Somatic Mutations and Splicing Variants of Focal Adhesion Kinase in Non–Small Cell Lung Cancer", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 110, no. 2, 1 February 2018 (2018-02-01), GB , pages 195 - 204, XP093020172, ISSN: 0027-8874, DOI: 10.1093/jnci/djx157
LING YAO , XIN-MIN ZHENG: "Progress in research of isoforms and mutations of FAK", CHEMISTRY OF LIFE, vol. 29, no. 1, 15 February 2009 (2009-02-15), pages 26 - 28, XP093020183, ISSN: 1000-1336, DOI: 10.13488/j.ismbx.2009.01.004
CHRISTEL DEVAUD; ANNE‐FRANÇOISE TILKIN‐MARIAMÉ; ALIX VIGNOLLE‐VIDONI; PHILIPPINE SOULERES; ALEXANDRE DENADAI‐SOUZA; CORINNE ROLLAN: "FAK alternative splice mRNA variants expression pattern in colorectal cancer", INTERNATIONAL JOURNAL OF CANCER, vol. 145, no. 2, 14 February 2019 (2019-02-14), US , pages 494 - 502, XP071290793, ISSN: 0020-7136, DOI: 10.1002/ijc.32120
FANG XUQIAN, LIU XIANGFAN, YAO LING, CHEN CHANGQIANG, LIN JIAFEI, NI PEIHUA, ZHENG XINMIN, FAN QISHI: "New Insights into FAK Phosphorylation Based on a FAT Domain-Defective Mutation", PLOS ONE, vol. 9, no. 9, 16 September 2014 (2014-09-16), pages 1 - 10, XP093020180, DOI: 10.1371/journal.pone.0107134
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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