Title:
FOLLICLE-STIMULATING HORMONE WITH HIGH SPECIFIC ACTIVITY AND PREPARATION METHOD THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/115318
Kind Code:
A1
Abstract:
A follicle-stimulating hormone(FSH) with high specific activity and preparation method thereof are disclosed, wherein specific activity of the follicle-stimulating hormone is not less than 7000 international unit (IU)/mg protein. The method for preparing the follicle-stimulating hormone with high specific activity comprises using cation exchange chromatography(CEX) to purify low-purity follicle-stimulating hormone, and using dye affinity chromatography to purify FSH after the CEX step sequentially. Thereby the follicle-stimulating hormone with high specific activity is obtained.
Inventors:
JI XIAOMING (CN)
GAO XIAOLIANG (CN)
JI BIN (CN)
YAN HUIMIN (CN)
HONG YUNHAI (CN)
GAO XIAOLIANG (CN)
JI BIN (CN)
YAN HUIMIN (CN)
HONG YUNHAI (CN)
Application Number:
PCT/CN2009/071981
Publication Date:
October 14, 2010
Filing Date:
May 26, 2009
Export Citation:
Assignee:
SHANGHAI TECHWELL BIOPHARMACEU (CN)
JI XIAOMING (CN)
GAO XIAOLIANG (CN)
JI BIN (CN)
YAN HUIMIN (CN)
HONG YUNHAI (CN)
JI XIAOMING (CN)
GAO XIAOLIANG (CN)
JI BIN (CN)
YAN HUIMIN (CN)
HONG YUNHAI (CN)
International Classes:
C07K14/59; A61K38/24; A61P15/08; C07K1/18; C07K1/22
Foreign References:
| US20080070832A1 | 2008-03-20 | |||
| US7446090B2 | 2008-11-04 | |||
| US5990288A | 1999-11-23 | |||
| CN1587276A | 2005-03-02 |
Attorney, Agent or Firm:
SHANGHAI PATENT & TRADEMARK LAW OFFICE, LLC (Xuhui, Shanghai 3, CN)
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