FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Title:

FORMAMIDE COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2019/206120

Kind Code:

A1

Abstract:

The present invention relates to a formamide compound, a preparation method therefor and an application thereof. The structure of the compound is shown in formula (I), and the definition of each variable in the formula is as provided in the description. The compound is capable of inhibiting the activity of ASK1 kinase. The compound of the present invention may be used in the treatment/prevention of diseases associated with ASK1 kinase, such as inflammatory diseases, metabolic diseases, autoimmune diseases, cardiovascular diseases, neurodegenerative diseases, cancers and other diseases.

More Like This:

JPS5528919	MEDICINE COMPRISING 5-(3'-PYRIDYL)-2-MERCAPTOIMIDAZOLE DERIVATIVE AS ACTIVE CONSTITUENT
JP2022536092	N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidine-4 as a human CTPS1 inhibitor for the treatment of proliferative diseases -yl)tetrahydro-2H-pyran-4-carboxamide derivatives and related compounds
JP2012525336	Pilidinone antagonist of α-4 integrin

Inventors:

YANG QIANJIAO (CN)
LU XIANPING (CN)
LI ZHIBIN (CN)
PAN DESI (CN)
SHAN SONG (CN)
WANG XIAOLIANG (CN)
SONG YONGLIAN (CN)
ZHANG KUN (CN)

Application Number:

PCT/CN2019/083829

Publication Date:

October 31, 2019

Filing Date:

April 23, 2019

Export Citation:

Click for automatic bibliography generation Help

Assignee:

SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD (CN)

International Classes:

C07D401/04; A61K31/4196; A61K31/4439; A61P3/00; A61P9/00; A61P25/00; A61P29/00; A61P35/00; A61P37/00; C07D403/04; C07D403/14; C07D411/04

Domestic Patent References:

WO2009027283A1	2009-03-05
WO2011041293A1	2011-04-07
WO2011008709A1	2011-01-20

Foreign References:

CN104080771A	2014-10-01
CN104918936A	2015-09-16
CN101878212A	2010-11-03
CN102482257A	2012-05-30
CN201810404758A	2018-04-28
US20120004267A1	2012-01-05
US20170173031A1	2017-06-22
US20110009410A1	2011-01-13

Other References:

CARGNELLO M.ROUX P. P., MICROBIOL. MOL. BIOL. REV., vol. 75, 2011, pages 50 - 83
SOGA M.MATSUZAWA A.ICHIJO H., INT. J. CELL BIOL., 2012, pages 1 - 5
HAYAKAWA R.HAYAKAWA T.TAKEDA K. ET AL., PROC.JPN.ACAD.SER.BPHYS.BIOL.SCI., vol. 88, 2012, pages 434 - 453
CISBIO, NATURE METHOD, 23 June 2006 (2006-06-23)
See also references of EP 3789384A4

Attorney, Agent or Firm:

SHENPAT INTELLECTUAL PROPERTY AGENCY (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: STACK FRAME FOR FLOW BATTERY

Next Patent: MANUFACTURING METHOD AND DEVICE OF FLOW BATTERY ELECTROLYTE