A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE

Title:

A FORMULATION OF A CONJUGATE OF A TUBULYSIN ANALOG TO A CELL-BINDING MOLECULE

Document Type and Number:

WIPO Patent Application WO/2020/258893

Kind Code:

A1

Abstract:

A formulation of conjugates of tubulysin analogs with a cell-binding molecule having a structure represented by Formula (I), wherein T, L, m, n, -----, R 1, R 2, R 3, R 4, R 5, R 6, R 7, R 8, R 9, R 10, R 11, R 12, and R 13 are as defined herein, can be used for targeted treatment of cancer, autoimmune disease, and infectious disease.

Inventors:

ZHAO ROBERT (US)
YANG QINGLIANG (CN)
HUANG YUANYUAN (CN)
GAI SHUN (CN)
YE HANGBO (CN)
ZHAO LINYAO (CN)
GUO HUIHUI (CN)
BAI LU (CN)
LI WENJUN (CN)
JIA JUNXIANG (CN)
GUO ZHIXIANG (CN)
ZHENG JUN (CN)
CHEN XIAOXIAO (CN)
KONG XIANGFEI (CN)
LIN CHEN (CN)
DU YONG (CN)
ZHANG YU (CN)
ZHOU LEI (CN)
ZHANG XIOUZHENG (CN)
ZHENG XIOUHONG (CN)
CHEN BINGBING (CN)
YANG YANLEI (CN)
DAI MENG (CN)
XU YIFANG (CN)
FANG ZHONGLIANG (CN)
ZHOU XIAOMAI (CN)
JIANG XINGYAN (CN)
CHEN MIAIMIAO (CN)
ZHANG LINGLI (CN)
LI YANHUA (CN)

Application Number:

PCT/CN2020/075709

Publication Date:

December 30, 2020

Filing Date:

February 18, 2020

Export Citation:

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Assignee:

HANGZHOU DAC BIOTECH CO LTD (CN)

International Classes:

A61K47/68; A61K9/08; A61K31/426; A61P35/00; C07D277/56

Domestic Patent References:

WO2019127607A1	2019-07-04
WO2016077260A1	2016-05-19
WO2017196598A1	2017-11-16

Foreign References:

CN109912683A	2019-06-21
CN109912683A	2019-06-21
US20150314017A1	2015-11-05
US20150322155A1	2015-11-12

Other References: