Title:
SIRNA/NANOPARTICLE FORMULATIONS FOR TREATMENT OF MIDDLE-EAST RESPIRATORY SYNDROME CORONAVIRAL INFECTION
Document Type and Number:
WIPO Patent Application WO/2017/044507
Kind Code:
A3
Abstract:
The present invention relates to compositions and methods for siRNA therapeutics for prevention and treatment of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) infections. The compositions include a pharmaceutical composition comprising siRNA cocktails that target viral genes and pharmaceutically acceptable polymeric nanoparticle carriers and liposomal nanoparticle carriers.
Inventors:
LU PATRICK Y (US)
SIMONENKO VERA (US)
CAI YIBIN (US)
XU JOHN (US)
EVANS DAVID (US)
SIMONENKO VERA (US)
CAI YIBIN (US)
XU JOHN (US)
EVANS DAVID (US)
Application Number:
PCT/US2016/050590
Publication Date:
May 26, 2017
Filing Date:
September 07, 2016
Export Citation:
Assignee:
SIRNAOMICS INC (US)
International Classes:
A61K39/215; A61K39/12; C07K16/10
Domestic Patent References:
| WO2015057966A2 | 2015-04-23 | |||
| WO2015081155A1 | 2015-06-04 | |||
| WO2011109698A1 | 2011-09-09 |
Foreign References:
| US20110275785A1 | 2011-11-10 | |||
| US20080070354A1 | 2008-03-20 | |||
| US20100204266A1 | 2010-08-12 | |||
| US20140235605A1 | 2014-08-21 |
Other References:
YANG, X ET AL.: "Proteolytic Processing, Deubiquitinase And Interferon Antagonist Activities Of Middle East Respiratory Syndrome Coronavirus Papain-Like Protease", JOURNAL OF GENERAL VIROLOGY, vol. 95, no. 3, 2014, pages 614 - 626, XP055383781
MEVEL, M ET AL.: "DODAG; A Versatile New Cationic Lipid That Mediates Efficient Delivery Of pDNA And siRNA'.", JOURNAL OF CONTROLLED RELEASE, vol. 143, no. 2, 2010, pages 222 - 232, XP055383792
MEVEL, M ET AL.: "DODAG; A Versatile New Cationic Lipid That Mediates Efficient Delivery Of pDNA And siRNA'.", JOURNAL OF CONTROLLED RELEASE, vol. 143, no. 2, 2010, pages 222 - 232, XP055383792
Attorney, Agent or Firm:
KARNY, Geoffrey, M. (US)
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