Title:
FOSAPREPITANT-CONTAINING LIQUID PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/078171
Kind Code:
A1
Abstract:
A Fosaprepitant-containing liquid pharmaceutical composition, a preparation method therefor, and a use thereof. The Fosaprepitant-containing liquid pharmaceutical composition comprises an active pharmaceutical ingredient, a chelating agent, a stabilizer, and a pH regulator. The active pharmaceutical ingredient comprises Fosaprepitant, and a pharmaceutically acceptable salt, hydrate or solvate of the Fosaprepitant-containing liquid pharmaceutical composition. The Fosaprepitant-containing liquid pharmaceutical composition does not contain polysorbate 80 and lactose. The Fosaprepitant-containing liquid pharmaceutical composition has the advantages of simple preparation process, good physical and chemical stability, convenience in clinical use, no need of redissolution, low microbial pollution risk in the preparation process, suitability for industrial production and the like.
Inventors:
CHEN ZHIXIANG (CN)
JIN HAIGANG (CN)
GUO ZHEN (CN)
FU JUN (CN)
WANG TINGTING (CN)
YING SHUHUAN (CN)
JIN HAIGANG (CN)
GUO ZHEN (CN)
FU JUN (CN)
WANG TINGTING (CN)
YING SHUHUAN (CN)
Application Number:
PCT/CN2022/128205
Publication Date:
May 11, 2023
Filing Date:
October 28, 2022
Export Citation:
Assignee:
SHANGHAI BOCIMED PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/675; A61K9/08; A61K47/02; A61P1/08
Foreign References:
| CN112243376A | 2021-01-19 | |||
| CN106943358A | 2017-07-14 | |||
| CN104042572A | 2014-09-17 | |||
| CN104414980A | 2015-03-18 | |||
| US20170216205A1 | 2017-08-03 |
Other References:
MARK ALLEN T. BIBERA ET AL.,: "Potential cross-reactivity of polysorbate 80 and cremophor: A case report", JOURNAL OF ONCOLOGY PHARMACY PRACTICE, vol. 26, no. 5, 31 December 2020 (2020-12-31), pages 1279 - 1281, XP009546029
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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