FRAGRANCE COMPOSITIONS

FIELD OF THE INVENTION

The present invention relates to the field of perfumery. In particular, the compositions of the present invention have improved intensity and/or longevity of the fragrance profile.

BACKGROUND OF THE INVENTION

It has been a long tradition that highly skilled perfumers carefully select fragrance materials to blend into a composition with the goal of achieveing an overall specific fragrance profile of strength and character. In so doing, they need to bear in mind differences in the individual character and volatility of the fragrance materials that are the components of the full fragrance. Conventional perfuming compositions have fragrance profile characterized by a high amount of the low volatile fragrance materials and lower amounts of the volatile fragrance materials. The low volatile fragrance materials are known as "base notes", while the volatile fragrance materials can be further divided into high volatile fragrance materials, identified as "top or head notes", and medium volatile fragrance materials, identified as "middle or heart notes".

The top notes tend to smell citrusy, green, light, fresh, and comprise typically from about 0.1 wt to 40 wt relative to the total weight of the perfume formulation. Top notes tend to evaporate quickly due to their high volatility and are characterized by vapor pressure > 0.1 Torr at 25°C (Calculated using Advanced Chemistry Development (ACD/Labs) Software VI 1.02 (© 1994-2013 ACD/Labs)). Typically, perfumers use top notes to deliver the initial impression of the composition but do not rely on them to contribute much to its overall fragrance profile over time after application.

Middle or heart notes make up from about 0.1 wt to about 40 wt relative to the total weight of the perfume formulation. Generally, they become dominant to the untrained nose from several minutes after application and can last up to a few hours afterwards. Middle notes are associated with floral aromas (e.g., jasmin, rose), fruity, marine or spicy aromas and have an intermediate volatity in the vapor pressure range of 0.001 to 0.1 Torr at 25°C.

Base or bottom notes can exist at >30 wt relative to the total weight of the perfume formulation. They are characterized as animalic, woody, sweet, amber or musky, not being very volatile and having a vapor pressure < 0.001 Torr at 25°C. Typically, they are not perceived as dominant until several hours after the application of the perfume or during "dry-down". Base notes are relied upon to improve the strength of the overall fragrance profile over time and replace the heart notes when these are declining, The consequence of using base notes at high levels is that they impart particular odour characters, such as for example, musky, woody, ambery, warm and sweet, which overpower and dominate the fragrance character over time. Some of these base notes have become such common materials (e.g., hedione, galaxolide, etc.) that many fragrance dry-downs appear repetitive, boring, non-memorable and un-interesting to consumers. However, if base notes are reduced or excluded then the fragrance strength weakens over time and does not last for a sufficient duration.

To date, due to the volatility of the fragrance materials, the possible types of fragrance profiles or characters have been somewhat limited. A common complaint by consumers is that middle notes tend to fade too quickly after application of the composition and that the character of the middle notes are undesirably altered by the presence of large amounts of the base notes during the period known as the "dry-down" phase.

Thus, it is desirable to have a composition which retains a significant portion of its initial fragrance character over time, hence, the floral, fruity or spicy characters of the 'heart notes' are perceived for many hours It is also desirable that the fragrance strength of the composition remains noticeable to the consumer over longer periods of time. It is further desirable to be able to create new to the world fragrance profiles wherein one, or several, well-recognized heart note characters, are maintained over time.

It is therefore a challenge to formulate a composition having improved longevity of the fragrance character, preferably components derived from the volatile fragrance materials, without having the fragrance character substantially altered over time by the presence of the base notes in the composition. One approach for addressing the challenge has been to formulate with higher proportions of perfume raw materials with a low volatility and which are therefore more substantive on the substrate. However, as discussed above, this restricts the type of fragrance profile that can be achieved over time.

Another approach, as disclosed in U.S. Patent 4,264,478 (Amerchol Corp.), has been to use a non-odorous material, such as an alkoxylated methyl glucoside, as a modulator to extend the longevity of the perfume raw materials, which are normally too volatile to last for very long. However, U.S. Patent '478 simply teaches the addition of the modulator to an existing fragrance composition with a traditional construction of high levels of base note materials. As such, the resultant overall effect on the fragrance profile of the composition would be to make the whole fragrance weaker because the impact of the modulator on the more volatile fragrance materials cannot be noticed due to the presence of excessive levels of the base notes in the composition. Similarly, Moshel, et ah, Perfumer & Flavorist, Vol. 7, pp.41-47, 1982, teaches that alkoxylated methyl glucosides function as a "fixative" and bind to individual perfume raw materials for improving the longevity of a particular perfume raw material. Moshel, et ah, shows that the fixative's ability to improve the longevity for any particular perfume raw material will depend on its boiling point. However, Moshel, et al., does not disclose or suggest how to formulate with the fixative for a full fragrance composition, which incorporates multiple perfume raw materials, so that the fragrance strength is maintained and the character of the middle notes is perceived as dominant after many hours.

As such the prior art teachings still have limitations, and does not adequately teach how to provide a composition wherein the prolonged fragrance profile has sufficient strength to be noticeable and remains distinctive in character over time. Therefore, there remains a need for a composition that is perceived by the consumer over long, preferably very long, duration after application. There is also a need for a composition which exhibits enhanced intensity of the fragrance profile over time, preferably so that the volatile fragrance materials remains significantly consistent from its initial impression to the end. It is desirable that the compositions are relevant to fragrances derived from volatile fragrance materials having a vapor pressure > 0.001 Torr at 25°C.

SUMMARY OF THE INVENTION

In a first aspect, the present invention is directed to a composition comprising a fragrance component present in the amount of from about 0.04 wt to about 30 wt%, relative to the total weight of the composition, and wherein the fragrance component comprises at least one low volatile fragrance material having a vapor pressure < 0.001 Torr at 25°C, present in an amount of from about 0.1 wt to about 30 wt%, relative to the total weight of the fragrance component, and at least one non-odorous fragrance modulator, preferably formed from an alkoxylated glucoside, present in the amount of from about 0.1 wt to about 20 wt%, relative to the total weight of the composition.

In another aspect, the present invention is directed to a composition wherein the fragrance component further comprising one or more volatile fragrance materials having a vapor pressure > 0.001 Torr at 25°C and present in the amount of from about 70 wt% to about 99.9 wt%, relative to the total weight of the fragrance component. In yet another aspect, the present invention is further directed to a method of modifying or enhancing the odour properties of a body surface with a composition of the present invention, by contacting or treating the body surface with the composition.

These and other features of the present invention will become apparent to one skilled in the art upon review of the following detailed description when taken in conjunction with the appended claims.

BRIEF DESCRIPTION OF THE DRAWINGS

While the specification concludes with claims particularly pointing out and distinctly claiming the invention, it is believed that the invention will be better understood from the following description of the accompanying figures wherein:

Figure 1 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition A" of the present invention comprising 8.00 wt of low volatile fragrance materials as compared to "Composition B", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 2 provides the panel test results of perceived fragrance profile, particularly fragrance character dominance, of "Composition A" of the present invention comprising 8.00 wt of low volatile fragrance materials as compared to "Composition B", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 3 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition C" of the present invention comprising 0.20 wt of low volatile fragrance materials as compared to "Composition D", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 4 provides the panel test results of perceived differences in the fragrance profile, particularly differences in the fragrance character, of "Composition C" of the present invention comprising 0.20 wt of low volatile fragrance materials as compared to "Composition D", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 5 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition N" of the present invention comprising 54 wt of low volatile fragrance materials as compared to "Composition O", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 6 provides the panel test results of perceived fragrance profile, particularly fragrance character dominance, of "Composition N" of the present invention comprising 54 wt of low volatile fragrance materials as compared to "Composition O", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 7 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition I" wherein the fragrance component comprises 40.14 wt of low volatile fragrance materials as compared to "Composition J", a control absent of a fragrance modulator (PPG-20 Methyl Glucose Ether), and as a function of time elapsed since application of the composition.

Figure 8 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition b" wherein the fragrance component comprises 1.0 wt of low volatile fragrance material as compared to "Composition a", a control composition absent of a fragrance modulator (Simulsol SLl 1 W™), and as a function of time elapsed since application of the composition.

Figure 9 provides the panel test results of perceived fragrance profile, particularly fragrance intensity, of "Composition d" wherein the fragrance component comprises 1.0 wt of low volatile fragrance material as compared to "Composition c", a control composition absent of a fragrance modulator (Plantacare ^® 810 UP), and as a function of time elapsed since application of the composition. DETAILED DESCRIPTION OF THE INVENTION

Definitions

As used herein, articles such as "a" and "an" when used in a claim, are understood to mean one or more of what is claimed or described.

As used herein, the terms "include", "includes" and "including" are meant to be non- limiting.

As used herein, the term "composition" includes a fine fragrance composition intended for application to a body surface, such as for example, skin or hair, i.e., to impart a pleasant odour thereto, or cover a malodour thereof. They are generally in the form of perfume concentrates, perfumes, eau de parfums, eau de toilettes, aftershaves, colognes, body splashes, or body sprays. The fine fragrance compositions may be ethanol based compositions. The term "composition" may also include a cosmetic composition, which comprises a fragrance material for the purposes of delivering a pleasant smell to drive consumer acceptance of the cosmetic composition. The term "composition" may also include cleaning compositions, such as fabric care composition or home care compositions, including air care compositions, for use on clothing or other substrates such as hard surfaces (e.g., dishes, floors, countertops). Additional non- limiting examples of "composition" may also include facial or body powder, foundation, body/facial oil, mousse, creams (e.g., cold creams), waxes, sunscreens and blocks, bath and shower gels, lip balms, self-tanning compositions , masks and patches.

As used herein, the term "consumer" means both the user of the composition and the observer nearby or around the user.

As used herein, the term "fragrance material" and "fragrance materials" relates to a perfume raw material, or a mixture of perfume raw materials, that are used to impart an overall pleasant odour or fragrance profile to a composition. "Fragrance materials" can encompass any suitable perfume raw materials for fragrance uses, including materials such as, for example, alcohols, aldehydes, ketones, esters, ethers, acetates, nitriles, terpene hydrocarbons, nitrogenous or sulfurous heterocyclic compounds and essential oils. However, naturally occurring plant and animal oils and exudates comprising complex mixtures of various chemical components are also know for use as "fragrance materials". The individual perfume raw materials which comprise a known natural oil can be found by reference to Journals commonly used by those skilled in the art such as "Perfume and Flavourist" or "Journal of Essential Oil Research", or listed in reference texts such as the book by S. Arctander, Perfume and Flavor Chemicals, 1969, Montclair, New Jersey, USA and more recently re-publisehd by Allured Publishing Corporation Illinois (1994). Additionally, some perfume raw materials are supplied by the fragrance houses (Firmenich, International Flavors & Fragrances, Givaudan, Symrise) as mixtures in the form of proprietary speciality accords. Non-limiting examples of the fragrance materials useful herein include pro- fragrances such as acetal pro-fragrances, ketal pro-fragrances, ester pro-fragrances, hydrolyzable inorganic-organic pro-fragrances, and mixtures thereof. The fragrance materials may be released from the pro-fragrances in a number of ways. For example, the fragrance may be released as a result of simple hydrolysis, or by a shift in an equilibrium reaction, or by a pH-change, or by enzymatic release. As used herein, the term "fragrance profile" means the description of how the fragrance perceived by the human nose evolves over time from when it is first applied. It is a result of the combination of the top, middle and base notes, if present, of a fragrance. A fragrance profile is composed of 2 characteristics: 'intensity' and 'character'. The 'intensity' relates to the perceived strength whilst 'character' refers to the odour impression or quality of the perfume, i.e., fruity, floral, woody, etc.

As used herein, the terms "perfume" and "fragrance" are used interchangeably to designate the component in the composition that is formed of fragrance materials, i.e., ingredients capable of imparting or modifying the odour of skin or hair or other substrate.

As used herein, the terms "modulator" and "fixative" are used interchangeably to designate an agent having the capacity to affect the fragrance profile by impacting the fragrance materials' evaporation rate. By incorporating the modulator, it is desired that the fragrance profile, preferably the volatile fragrance materials components, of the composition can be perceived by an observer or user thereof, over a longer period of time, as compared to the same perception in the absence of the modulator. In particular, according to the invention, alkoxylated glucoside, preferably PPG-20 Methyl Glucose Ether (Glucam™ P-20 available from Lubrizol (USA)), is a modulator of the perceived tenacity of the compositions of the present invention, i.e., it is used to prolong the perceived intensity of the fragrance profile over time, as compared to the perception when PPG-20 Methyl Glucose Ether is not used in the composition. However, as discovered by the inventors, simply adding modulators to a traditionally constructed fragrance composition will not ensure an improved or enhanced fragrance profile over time. Instead, it is only when the modulators are added in the presence of reduce levels of low volatile fragrance materials can the intensity of the fragrance profile, preferably the volatile fragrance materials, be perceived for longer periods as compared to control composition absent the modulators and low levels of low volatile fragrance materials.

As used herein, the term "co-modulator" means an agent that is added to the composition in addition to the modulators and has the similar function of impacting the evaporation rate and intensity of the fragrance materials, so as to improve or prolong the perception of the fragrance profile by the consumer. Preferred example of a co-modulator is isocetyl alcohol (CERAPHYL ^® ICA; see PCT Publication No. WO2013/64412 (Firmenich)).

As used herein, the term "non-odorous" means an agent that does not impart an odour of its own when added into a composition of the present invention. For example, a "non-odorous modulator" such as PPG-20 Methyl Glucose Ether does not impart a new odour that alters the character of the composition to which it is added.

As used herein, the term "vapor pressure" means the partial pressure in air at a defined temperature for a given chemical species. It defines a chemical species' desire to be in the gas phase rather than the liquid or solid state. The higher the vapour pressure the greater the proportion of the material that will, at equilibrium, be found in a closed headspace. It is also related to the rate of evaporation of a fragrance material which is defined in an open environment where material is leaving the system. The vapor pressure is determined according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 11.02, (© 1994-2013).

It is understood that the test methods that are disclosed in the Test Methods Section of the present application must be used to determine the respective values of the parameters of Applicants' inventions as described and claimed herein.

In all embodiments of the present invention, all percentages are by weight of the total composition, as evident by the context, unless specifically stated otherwise. All ratios are weight ratios, unless specifically stated otherwise, and all measurements are made at 25°C, unless otherwise designated.

Compositions

Specifically, in one aspect, the present invention provides for a composition comprising a fragrance component present in an amount of from about 0.04 wt to 30 wt%, preferably 1 wt to about 30 wt%, preferably less than about 25 wt%, preferably less than about 20 wt%, preferably less than about 15 wt%, preferably less than about 10 wt% or preferably less than about 8 wt%, relative to the total weight of the composition. Alternatively, the fragrance component is present in an amout of from about 0.04 wt%, 0.3 wt%, 1 wt%, 8 wt% or 10 wt%, to about 15 wt%, 20 wt%, 25 wt% or 30 wt%, relative to the total weight of the composition.

Further, the fragrance component comprises at least one low volatile fragrance material having a vapor pressure < 0.001 Torr at 25°C. In certain embodiments, the compositions of the present invention comprises at least 5 low volatile fragrance materials. It is preferred that the composition of the present invention comprises low, preferably very low, or even neglible, levels of the low volatile fragrance materials than would traditionally be present in a composition. As such, compositions of the present invention can comprise low levels of the volatile fragrance material present in an amount of from about 0.01 wt% to about 30 wt%, preferably less than about 25%, preferably less than about 20 wt%, preferably less than about 12 wt%, preferably less than about 10 wt%, preferably less than about 8 wt%, preferably less than about 5 wt%, preferably less than about 2 wt%, or preferably less than about 1 wt%, or combinations thereof, relative to the total weight of the fragrance component. Alternatively, the low volatile fragrance material is present in an amount of from about 0.01 wt%, 1 wt%, 2 wt%, 5 wt%, 8 wt%, 10 wt%, 12 wt%, 15 wt%, 20 wt%, 25 wt% or 30 wt%, relative to the total weight of the fragrance component. If there is more than one low volatile fragrance materials, then the ranges provided hereinabove cover the total of all of the low volatile fragrance materials.

The composition further comprises at least one non-odorous fragrance modulator formed from an alkoxylated glucoside, preferably selected from the group consisting of methyl glucoside polyol, ethyl glucoside polyol, and propyl glucoside polyol, wherein the alkoxylated glucoside is preferably PPG-20 Methyl Glucose Ether (GLUCAM™ P-20 avilable from Lubrizol, USA). The alkoxylated glucoside is present in an amount of from about 0.1 wt% to about 20 wt%, preferably from about 0.5 wt% to about 18 wt% or more preferably from about 2.5 wt% to about 15 wt% or combinations thereof, relative to the total weight of the composition. Alternatively, the alkoxylated glucoside is present in an amount of from about 0.1 wt%, 0.5 wt% or 2.5 wt% to about 15 wt%, 18 wt% or 20 wt%, relative to the total weight of the composition. If there is more than one non-odorous fragrance modulators, then the ranges provided hereinabove cover the total of all of the non-odorous fragrance modulators.

In an embodiment, the non-odorous modulator of the present invention is preferably a liquid at temperatures lower than 100°C, preferably at ambient temperature. Particularly preferred non-odorous modulators are fully miscible with the PRMs to form a single phase liquid. However, if the PRMs are not entirely miscible, or are immiscible, then co-solvents (e.g., dipropylene glycol (DPG), triethyl citrate, or others as well known to those skilled in the art) can be added to aid in the solubility of the PRMs.

The inventors have surprisingly discovered that by reducing the levels of the low volatile fragrance materials (i.e., base notes) in a composition, the effect of the non-odorous modulator on the fragrance profile, particularly the portion of the fragrance profile which is derived from volatile fragrance materials (i.e., top and middle notes), can be improved. By "improved" it is meant that the fragrance character of the composition, particular the components contributed by the volatile fragrance materials, can be perceived by the consumer at later time points such as, for example, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, and possibly all the way up to 24 hrs after application as compared to controls, i.e., compositions containing normal or large levels of the low volatile fragrance materials and the non-odorous modulator or compositions containing reduced levels of low volatility fragrance materials and no non-odorous modulator.

Alternatively, by "improved" it can mean that the perception of the components contributed by the volatile fragrance materials, by the consumer, is markedly increased or enhanced as compared to the controls. "Increased" or "enhanced" perception of the fragrance profile means that the consumer perceives the fragrance profile of a composition as not changing from its initial impression or the changes are minimal from when the composition was first applied to when it dissipates.

Typically, it has been very difficult to formulate fragrance profile with an accord, particularly a floral accord characteristic of the middle notes, which can last for very long periods, especially throughout the life of the composition after its application, without giving way to the stronger odours of the base notes. The present invention of reducing levels of the low volatile fragrance materials (i.e., base notes) with the modulators will allow perfumers to increase the perception of the volatile perfume materials, particularly the middle notes, to create new characters and address a re-occurring consumer issue that particular fragrance profiles, particularly the floral aromas, do not last long enough.

Such a solution as presented herein provides enhanced longevity of the fragrance profile, particularly amongst those composition formulated from volatile fragrance materials having medium to high vapor pressure ranges (> 0.001 Torr at 25°C), without having to rely on the presence or significant amounts of the low volatile fragrance materials, which has a tendency to overpower and alter the overall character of a fragrance. This provides the perfumer options to formulate accords having new fragrance profiles.

In another aspect, the present invention also provides a composition, wherein the fragrance component further comprising one or more volatile fragrance materials having a vapor pressure > 0.001 Torr at 25°C. The volatile fragrance material is present in an amount of from about 70 wt to about 99.9 wt%, preferably greater than about 80 wt%, or most preferably greater than 88 wt%, or combinations thereof, relative to the total weight of the fragrance component. Alternatievly, the volatile fragrance material is present in an amount of from about 70 wt%, 75 wt%, 80 wt%, 85 wt%, 88 wt%, 90 wt%, 92 wt , 95 wt%, 98 wt% or 99.9 wt%, relative to the total weight of the fragrance component. In certain embodiments, the compositions of the present invention comprise at least 5, at least 10, at least 15 or at least 20, volatile fragrance materials. If there is more than one volatile fragrance materials, then the ranges provided hereinabove cover the total weight of all of the volatile fragrance materials. In one embodiment, the volatile fragrance materials can be divided into: (i) a high volatile fragrance material having a vapor pressure > 0.1 Torr at 25°C, and (ii) a medium volatile fragrance material having a vapor pressure in the range of from 0.001 Torr at 25 °C to 0.1 Torr at 25°C. While the further classification of the volatile fragrance materials into high and medium volatile fragrance materials is provided to help illustrate the fragrance characters of the perfume raw materials and is useful for when it comes to formulating new fragrance profiles, it should not be construed as limiting on what qualifies as a volatile fragrance material.

In yet another aspect, the low volatile fragrance material is preferably selected from ingredients listed in Table 1 hereinafter.

In yet another aspect, the present invention also provides a composition further comprising one or more non-odorous fragrance co-modulators selected from the group consisting of:

(i) Isocetyl alcohol (CERAPHYL ^® ICA);

(ii) PPG-3 myristyl ether (preferably Tegosoft™ APM and/or Varonic ^® APM);

(iii) Neopentyl glycol diethylhexanoate (preferably Schercemol™ NGDO); and

(iv) mixture thereof preferably with isocetyl alcohol (CERAPHYL ^® ICA); wherein the fragrance co-modulators are present in an amount of from about 0.05 wt to about 10 wt%, preferably from about 0.5 wt to about 6 wt%, or combinations thereof, relative to the total weight of the composition. Alternatively, the fragrance co-modulators is present in an amount of from about 0.05 wt or 0.5 wt to about 6 wt or 10 wt%, relative to the total weight of the composition. If there is more than one non-odorous fragrance co-modulator, then the ranges provided hereinabove cover all of the non-odorous fragrance co-modulators.

In one embodiment, the non-odorous fragrance modulators are formed of at least 50 wt of a non-odorous fragrance modulator, relative to the total weight of the non-odorous modulators and the non-odorous co-modulators present in the composition.

In yet another aspect, the present invention provides a composition comprising:

(i) from about 50 wt to about 80 wt of ethanol;

(ii) from about 0.1 wt to about 20 wt of at least one non-odorous fragrance modulator formed of an alkoxylated glucoside selected from the group consisting of methyl glucoside polyol, ethyl glucoside polyol, and propyl glucoside polyol, preferably PPG-20 Methyl Glucose Ether; and (iii) a fragrance component;

and wherein wt of the non-odorous fragrance modulator is greater than the fragrance component.

Entrapment Materials

In yet another aspect, compositions of the present invention may comprise an entrapment material at a level such that the weight ratio of the entrapment material to the fragrance materials is in the range of from about 1:20 to about 20: 1. Preferably, the composition may comprise an entrapment material present in the amount of from about 0.001 wt to about 40 wt%, from about 0.1 wt% to about 25 wt%, from about 0.3 wt% to about 20 wt%, from about 0.5 wt% to about 10 wt%, or from about 0.75 wt% to about 5 wt%, relative to the total weight of the composition. The compositions disclosed herein may comprise from 0.001 wt% to 40%, from 0.1 wt% to 25 wt%, from 0.3 wt% to 20 wt%, from 0.5 wt% to 10 wt% or from 0.75 wt% to 5 wt%, relative to the total weight of the composition, of a cyclic oligosaccharide.

Suitable entrapment materials for use herein are selected from polymers; capsules, microcapsules and nanocapsules; liposomes, absorbents; cyclic oligosaccharides and mixtures thereof. Preferred are absorbents and cyclic oligosaccharides and mixtures thereof. Highly preferred are cyclic oligosaccharides {see PCT Publication Nos. WO2000/67721 (Procter & Gamble); and WO2000/67720 (Procter & Gamble); and U.S. Patent No. US 6,893,647 (Procter & Gamble)).

As used herein, the term "cyclic oligosaccharide" means a cyclic structure comprising six or more saccharide units. Preferred for use herein are cyclic oligosaccharides having six, seven or eight saccharide units and mixtures thereof, more preferably six or seven saccharide units and even more preferably seven saccharide units. It is common in the art to abbreviate six, seven and eight membered cyclic oligosaccharides to α, β and γ respectively.

The cyclic oligosaccharide of the compositions used for the present invention may comprise any suitable saccharide or mixtures of saccharides. Examples of suitable saccharides include, but are not limited to, glucose, fructose, mannose, galactose, maltose and mixtures thereof. However, preferred for use herein are cyclic oligosaccharides of glucose. The preferred cyclic oligosaccharides for use herein are a-cyclodextrins or β-cyclodextrins, or mixtures thereof, and the most preferred cyclic oligosaccharides for use herein are β-cyclodextrins.

The cyclic oligosaccharide, or mixture of cyclic oligosaccharides, for use herein may be substituted by any suitable substituent or mixture of substituents. Herein the use of the term "mixture of substituents" means that two or more different suitable substituents can be substituted onto one cyclic oligosaccharide. The derivatives of cyclodextrins consist mainly of molecules wherein some of the OH groups have been substituted. Suitable substituents include, but are not limited to, alkyl groups; hydroxyalkyl groups; dihydroxyalkyl groups; (hydroxyalkyl) alkylenyl bridging groups such as cyclodextrin glycerol ethers; aryl groups; maltosyl groups; allyl groups; benzyl groups; alkanoyl groups; cationic cyclodextrins such as those containing 2-hydroxy-3- (dimethylamino) propyl ether; quaternary ammonium groups; anionic cyclodextrins such as carboxyalkyl groups, sulphobutylether groups, sulphate groups, and succinylates; amphoteric cyclodextrins; and mixtures thereof.

The substituents may be saturated or unsaturated, straight or branched chain. Preferred substituents include saturated and straight chain alkyl groups, hydroxyalkyl groups and mixtures thereof. Preferred alkyl and hydroxyalkyl substituents are selected from C Cg alkyl or hydroxyalkyl groups or mixtures thereof, more preferred alkyl and hydroxyalkyl substituents are selected from CrC ₆ alkyl or hydroxyalkyl groups or mixtures thereof, even more preferred alkyl and hydroxyalkyl substituents are selected from CrC ₄ alkyl or hydroxyalkyl groups and mixtures thereof. Especially preferred alkyl and hydroxyalkyl substituents are propyl, ethyl and methyl, more especially hydroxypropyl and methyl and even more preferably methyl.

Preferred cyclic oligosaccharides for use in the present invention are unsubstituted, or are substituted by only saturated straight chain alkyl, or hydroxyalkyl substituents. Therefore, preferred examples of cyclic oligosaccharides for use herein are a-cyclodextrin, β-cyclodextrin, methyl-a-cyclodextrin, methyl- β-cyclodextrin, hydroxypropyl-a-cyclodextrin and hydroxypropyl-P-cyclodextrin. Most preferred examples of cyclic oligosaccharides for use herein are methyl-a-cyclodextrin and methyl-P-cyclodextrin. These are available from Wacker-Chemie GmbH Hanns-Seidel-Platz 4, Munchen, DE under the tradename Alpha W6 M and Beta W7 M respectively. Especially preferred is methyl-P-cyclodextrin.

The cyclic oligosaccharides of the compositions used for the present invention are preferably soluble in water, ethanol, or both water and ethanol. As used herein "soluble" means at least about 0.1 g of solute dissolves in 100 mL of solvent, at 25°C and 1 atm of pressure. Preferably the cyclic oligosaccharides for use herein have a solubility of at least about 1 g/100 mL, at 25°C and 1 atm of pressure. Preferred is that cyclic oligosaccharides are only present at levels up to their solubility limits in a given composition at room temperature. A person skilled in the art will recognise that the levels of cyclic oligosaccharides used in the present invention will also be dependent on the components of the composition and their levels, for example the solvents used or the exact fragrance oils, or combination of fragrance oils, present in the composition. Therefore, although the limits stated for the entrapment material are preferred, they are not exhaustive.

Volatile Solvents

In yet another aspect, the present invention provides the solution to the problem of extending the longevity of the fragrance profile of compositions, particularly fine fragrance and cosmetic compositions, preferably fine fragrance compositions, which commonly contain high levels of ethanol or other alcohols (e.g., methanol, propanol, isopropanol, butanol, and mixtures thereof) commonly found in commercial fine fragrance products. Accordingly, ethanol may be present in any of the compositions of the present invention, and more specifically, it will form from about 10 wt to about 80 wt%, or even from about 25 wt to about 75 wt of the composition, or combinations thereof, relative to the total weight of the composition. Alternatively, ethanol may be present in an amount of from about 10 wt or 25 wt to about 75 wt or 80 wt%, relative to the total weight of the composition. Any acceptable quality of ethanol, compatible and safe for the specific intended use of the composition such as, for example, topical applications of fine fragrance or cosmetic compositions, and is convenient for use in the compositions according to the present invention.

Non- Volatile Solvents

The composition may comprise a non-volatile solvent or a mixture of non-volatile solvents. Non-limiting examples of non-volatile solvents include benzyl benzoate, diethyl phthalate, isopropyl myristate, propylene glycol, dipropylene glycol, triethyl citrate, and mixtures thereof. These solvents often are introduced to the product via the perfume oil as many perfume raw materials may be purchased as a dilution in one of these solvents. Where non-volatile solvents are present, introduced either with the perfume materials or separately, then for the purposes of calculating the proportion of fragrance component having a vapour pressure of < 0.001 Torr at 25°C the total fragrance components does not include non- volatile solvents. In addition if present with cyclic oligosacchrides, the non-volatile solvent may be included at a weight ratio of the non- volatile solvent to the cyclic oligosaccharide of less than 1 : 1, less than 1 :2, less than 1 : 10, or less than 1 : 100.

Water

In yet another aspect, water may be present in any of the compositions of the present invention, and more specifically, it shall not exceed about 40 wt%, preferably about 20 wt or less, or more preferably about 10 wt or less, relative to the total weight of the composition. Alternatively, water may be present in an amount of from about 10 wt or 20 wt to about 40 wt%, relative to the total weight of the composition. When the composition is a cosmetic composition the level of water should not be so high that the product becomes cloudy thus negatively impacting the product aesthetics. It is understood that the amount of water present in the composition may be from the water present in the ethanol used in the composition, as the case may be.

Propellants

The compositions described herein may include a propellant. Some examples of propellants include compressed air, nitrogen, inert gases, carbon dioxide, and mixtures thereof. Propellants may also include gaseous hydrocarbons like propane, n-butane, isobutene, cyclopropane, and mixtures thereof. Halogenated hydrocarbons like 1,1-difluoroethane may also be used as propellants. Some non-limiting examples of propellants include 1,1,1,2,2- pentafluoroethane, 1,1,1,2-tetrafluoroethane, 1,1,1, 2,3, 3,3-heptafluoropropane, trans- 1,3,3, 3- tetrafluoroprop-l-ene, dimethyl ether, dichlorodifluoromethane (propellant 12), 1,1-dichloro- 1,1,2,2-tetrafluoroethane (propellant 114), l-chloro-l,l-difluoro-2,2-trifluoroethane (propellant 115), l-chloro-l,l-difluoroethylene (propellant 142B), 1,1-difluoroethane (propellant 152A), monochlorodifluoromethane, and mixtures thereof. Some other propellants suitable for use include, but are not limited to, A-46 (a mixture of isobutane, butane and propane), A-31 (isobutane), A- 17 (n-butane), A- 108 (propane), AP70 (a mixture of propane, isobutane and n- butane), AP40 (a mixture of propane, isobutene and n-butane), AP30 (a mixture of propane, isobutane and n-butane), and 152A (1,1 diflouroethane). The propellant may have a concentration from about 15%, 25%, 30%, 32%, 34%, 35%, 36%, 38%, 40%, or 42% to about 70%, 65%, 60%, 54%, 52%, 50%, 48%, 46%, 44%, or 42% by weight of the total fill of materials stored within the container.

Antiperspirant Active

The compositions described herein may be free of, substantially free of, or may include an antiperspirant active (i.e., any substance, mixture, or other material having antiperspirant activity). Examples of antiperspirant actives include astringent metallic salts, like the inorganic and organic salts of aluminum, zirconium and zinc, as well as mixtures thereof. Such antiperspirant actives include, for example, the aluminum and zirconium salts, such as aluminum halides, aluminum hydroxyhalides, zirconyl oxyhalides, zirconyl hydroxyhalides, and mixtures thereof. Other Ingredients

In yet another aspect, the composition consists essentially of the recited ingredients but may contain small amounts (not more than about 10 wt%, preferably no more than 5 wt%, or preferably no more than 2 wt thereof, relative to the total weight of the composition) of other ingredients that do not impact on the fragrance profile, particularly the evaporation rate and release of the fragrance materials. For example, a fine fragrance composition may comprise stabilizing or anti-oxidant agents, UV filters or quenchers, or colouring agents, commonly used in perfumery. There are a number of other examples of additional ingredients that are suitable for inclusion in the present compositions, particularly in compositions for cosmetic use. These include, but are not limited to, alcohol denaturants such as denatonium benzoate; UV stabilisers such as benzophenone-2; antioxidants such as tocopheryl acetate; preservatives such as phenoxyethanol, benzyl alcohol, methyl paraben, and propyl paraben; dyes; pH adjusting agents such as lactic acid, citric acid, sodium citrate, succinic acid, phosphoric acid, sodium hydroxide, and sodium carbonate; deodorants and anti-microbials such as farnesol and zinc phenolsulphonate; humectants such as glycerine; oils; skin conditioning agents such as allantoin; cooling agents such as trimethyl isopropyl butanamide and menthol; hair conditioning ingredients such as panthenol, panthetine, pantotheine, panthenyl ethyl ether, and combinations thereof; silicones; solvents such as hexylene glycol; hair-hold polymers such as those described in PCT Publication WO94/08557 (Procter & Gamble); salts in general, such as potassium acetate and sodium chloride and mixtures thereof.

In yet another aspect, the composition of the present invention, depending on its intended use, is a mixture of fragrance materials possibly together with other ingredients such as, for example, perfume carriers. By the term "perfume carrier", it is meant to include materials which are practically neutral from a perfumery point of view, i.e., which does not significantly alter the organoleptic properties of perfuming components. The perfume carrier may be a compatible liquid or solid fillers, diluents, extenders and the like. The term "compatible", as used herein, means that the components of the compositions of this invention are capable of being combined with the primary actives of the present invention, and with each other, in a manner such that there is no interaction which would substantially reduce the efficacy of the composition under ordinary use situations. The type of carrier utilized in the present invention depends on the type of product desired and may comprise, but are not limited to, solutions, aerosols, emulsions (including oil-in- water or water- in-oil), gels, and liposomes. Preferably, the carrier is a liquid and will be a solvent such as, for example, dipropyleneglycol, diethyl phthalate, isopropyl myristate, benzyl benzoate, 2-(2-ethoxyethoxy)-l-ethanol, or ethyl citrate (triethyl citrate).

In yet another aspect, the compositions for use in the present invention may take any form suitable for use, more preferably for perfumery or cosmetic use. These include, but are not limited to, vapour sprays, aerosols, emulsions, lotions, liquids, creams, gels, sticks, ointments, pastes, mousses, powders, granular products, substrates, cosmetics (e.g. semi-solid or liquid makeup, including foundations) and the like. Preferably the compositions for use in the present invention take the form of a vapour spray. Compositions of the present invention can be further added as an ingredient to other compositions, preferably fine fragrance or cosmetic compositions, in which they are compatible. As such they can be used within solid composition or applied substrates etc.

It has been ascertained that, amongst such compositions of the present invention, the preferred compositions are those comprising of:

(i) a fragrance component present in the amount of from about 1.0 wt to about 30 wt relative to the total weight of the composition, and wherein the fragrance component comprises:

(a) at least one low volatile fragrance material having a vapor pressure < 0.001 Torr at 25°C, present in the amount of from about 0.1 wt to about 30 wt%, preferably less than about 28 wt%, preferably less than about 25 wt%, preferably less than about 22 wt%, preferably less than 20 wt%, preferably less than 18 wt%, or preferably less than 15 wt%, relative to the total weight of the fragrance component; and

(b) at least one volatile fragrance material having a vapor pressure > 0.001 Torr at 25°C, present in the amount of from about 70 wt% to about 99.9 wt%, relative to the total weight of the fragrance component; and

(ii) at least one non-odorous fragrance modulator formed of an alkoxylated glucoside, preferably PPG-20 Methyl Glucose Ether, in the amount of from about 2.5 wt% to about 20 wt%, relative to the total weight of the composition.

In an embodiment, the composition further comprises one or more non-odorous fragrance co-modulators selected from the group consisting of isocetyl alcohol (CERAPHYL ^® ICA), PPG- 3 myristyl ether (preferably Tegosoft™ APM and/or Varonic® APM), neopentyl glycol diethylhexanoate (preferably Schercemol™ NGDO), and mixture thereof preferably with isocetyl alcohol (CERAPHYL ICA), present in the amount of from about 0.5 wt% to about 10 wt%, relative to the total weight of the composition.

Therefore, it goes without saying that the compositions of the present invention encompasses any composition comprising any of the ingredients cited herein, in any embodiment wherein each such ingredient is independently present in any appropriate amount as defined herein. Many such compositions, than what is specifically set out herein, can be encompassed. Article of Manufacture

The composition may be included in an article of manufacture comprising a spray dispenser. The spray dispenser may comprise a vessel for containing the composition to be dispensed. The spray dispenser may comprise an aerosolized composition (i.e. a composition comprising a propellant) within the vessel as well. Other non-limiting examples of spray dispensers include non-aerosol dispensers (e.g. vapor sprays), manually activated dispensers, pump-spray dispensers, or any other suitable spray dispenser available in the art.

Methods of Using the Compositions

The composition of the present invention according to any embodiments described herein is a useful perfuming composition, which can be advantangeously used as consumer products intended to perfume any suitable substrate. As used herein, the term "substrate" means any surface to which the composition of the present invention may be applied to without causing any undue adverse effect. For example, this can include a wide range of surfaces including human or animal skin or hair, paper (fragranced paper), air in a room (air freshner or aromatherapy composition), fabric, furnishings, dishes, hard surfaces and related materials. Preferred substrates include body surfaces such as, for example, hair and skin, most preferably skin.

The composition of the present invention may be used in a conventional manner for fragrancing a substrate. An effective amount of the composition, typically from about 1 μL· to about 10,000 μί, preferably from about 10 μΐ _^ to about 1,000 μί, more preferably from about 25 μL· to about 500 μί, or most preferably from about 50 μΐ _^ to about 100 μί, or combinations thereof, is applied to the suitable substrate. Alternatively, an effective amount of the composition of the present invention is from about 1 μί, 10 μί, 25 μΐ _^ or 50 μΐ _^ to about 100 μί, 500 μί, 1,000 μΐ _^ or 10,000 μΐ _^ . The composition may be applied by hand or applied utilizing a delivery apparatus such as, for example, vaporizer or atomizer. Preferably, the composition is allowed to dry after its application to the substrate. The scope of the present invention should be considered to cover one or more distinct applications of the composition or the continuous release of a composition via a vaporizer or other type of atomizer. In one embodiment, present invention preferably relates to fine fragrance compositions in the form of a perfume, an eau de toilette, an eau de parfum, a cologne, a body splash, or a body spray. Therefore, according to this embodiment, the present invention provides a method of modifying or enhancing the odour properties of a body surface, preferably hair or skin, comprising contacting or treating the body surface with a composition of the present invention.

In another embodiment, the present invention relates to compositions of the present invention that may be used as consumer products or articles selected from the group consisting of a fabric care product, an air care product, or a home care product. Therefore, according to this embodiment, the present invention provides a method of modifying or enhancing the odour properties of a substrate, preferably fabric, furnishings, dishes, hard surfaces and related materials, comprising contacting or treating the substrate with a composition of the present invention.

In another aspect, the present invention is directed to a method of enhancing the fragrance profile of a composition, preferably by improving the longevity of an aroma of the composition. The method comprises bringing into contact or mixing at least one non-odorous fragrance modulator with at least one low volatile fragrance material according to the composition of the present invention. Preferably, the aroma is derived from the volatile fragrance materials in the composition and is characterized by a floral aroma. Non-limiting examples of floral aroma include lavender-type note, a rose-type note, a lily of the valley-type note, a muguet-type note, a jasmine-type note, a magnolia- type note, a cyclamen-type note, a hyacinth-type note, a lilac-type note, an orange blossom-type note, a cherry blossom-type note, a peony-type note, a lotus-type note, a linden blossom-type note, an osmanthus-type note, a lilac-type note, a heliotrope-type note, a violet-type note, an orris-type note, a tiare-type note and the like.

In one embodiment, the fragrance profile or aroma of the composition is detectable by a consumer at later time points such as, for example, 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, and possibly all the way up to 24 hours after application of the composition to a substrate as compared to controls.

Fragrance Materials

In order that the compositions can be developed with the appropriate fragrance profile for the present invention, the "fragrance materials" have been classified by their vapour pressure, as determined according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 11.02, (1994-2013). For the purpose of clarity, when the fragrance materials refer to a single individual compound, its vapor pressure should be determined according to the reference program cited above. In the case that the fragrance materials are a natural oil, extract or absolute, which comprises a mixture of several compounds, the vapor pressure of the complete oil should be treated a a mixture of the individual perfume raw material components using the reference program cited above. The individual components and their level, in any given natural oil or extract, can be determined by direct injection of the oil into a GC-MS column for analysis as known by one skilled in the art. In the scenario that the fragrance materials are a proprietary speciality accord, so called 'bases', the vapor pressure, using the reference program cited above, should preferably be obtained from the supplier. However, it is understood by one skilled in the art that they can physically analyze the composition of a full fragrance oil available commercially to identity the fragrance raw materials and their levels using standard GC-MS techniques. This would be irrespective of wether they had been added to the fragrance oil as individual chemicals, as components of naturals or from proprietary bases. Although proprietary bases and and naturals are included in our examples, when analyzing a commercially available fragrance via GC-MS one could simply identify the components of the base or natural oil as part of the overall fragrance mixture and their levels, without being able to identify which proprietary base or natural oil the fragrance had come from.

The nature and type of fragrance materials in the compositions according to the present invention can be selected by the skilled person, on the basis of its general knowledge together with the teachings contained herein, with reference to the intended use or application of the composition and the desired fragrance profile effect. Examples of suitable fragrance materials are disclosed in U.S. Pat. No. 4,145,184, U.S. Pat. No. 4,209,417, U.S. Pat. No. 4,515,705, and U.S. Pat. No. 4,152,272, provided that the composition comprises low volatile fragrance materials at levels in an amount of from about 0.1 wt to about 30 wt%, preferably less than about 28 wt%, preferably less than about 25 wt%, preferably less than about 22 wt%, preferably less than 20 wt%, preferably less than 18 wt%, or preferably less than 15 wt%, or combinations thereof, relative to the total weight of the fragrance component.

Examples of fragrance materials having a vapor pressure < 0.001 Torr at 25°C (according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 11.02, (© 1994-2013)) to form the at most about 30 wt% of the low volatile fragrance materials are listed in Table 1 hereinafter. Table 1 - Low Volatile Fragrance Materials for Use in the Compositions

CAS Vapor Pressure Number Chemical name Common Name**

(Torr at 25°C)*

Cyclopentaneacetic acid, 3-oxo-

1211-29-6 2-(2Z)-2-penten-l-yl-, methyl Methyl jasmonate 0.00096500 ester, (1R.2R)-

2-Buten-l-ol, 2-methyl-4-(2,2,3-

28219-60-5 Hindinol 0.00096100 trimethyl-3-cyclopenten- 1-yl)-

Methyl beta-naphthyl

93-08-3 Ethanone, l-(2-naphthalenyl)- 0.00095700 ketone

Methyl Lavender

67633-95-8 3-Decanone, 1-hydroxy- 0.00095100

Ketone

Cyclopropanemethanol, 1- methyl-2- [(1,2,2-

198404-98-7 Javanol ^® 0.00090200 trimethylbicyclo[3.1.0]hex-3-yl)

methyl] -

Benzaldehyde, 3-ethoxy-4-

121-32-4 Ethyl vanillin 0.00088400 hydroxy-

2H-l,5-Benzodioxepin-3(4H)-

28940-11-6 Oxalone ^® 0.00083100 one, 7-methyl-

2-Butanol, l-[[2-(l,l-

139504-68-0 Amber core 0.00080300 dimethylethyl)cyclohexyl]oxy]-

Spiro[5.5]undec-8-en-l-

Spiro[5.5]undec-8-en-l-one, 2,2,

502847-01-0 one, 2,2,7,9- 0.00073100

7,9-tetramethyl- tetramethyl-

Cyclopentaneacetic acid, 3-oxo-

2570-03-8 2-pentyl-, methyl ester, (1R,2R)- trans-Hedione 0.00071000 rel-

Cyclopentaneacetic acid, 3-oxo- Methyl

24851-98-7 0.00071000

2-pentyl-, methyl ester dihydroj asmonate

Hexyl cinnamic

101-86-0 Octanal, 2-(phenylmethylene)- 0.00069700 aldehyde

Cyclopentanecarboxylic acid, 2-

37172-53-5 Dihydro Iso Jasmonate 0.00067500 hexyl-3-οχο-, methyl ester

3-Cyclopentene-l-butanol, α,β,2,

65113-99-7 Sandalore ^® 0.00062500

2,3-pentamethyl-

Cyclopentanone, 2-(3,7-dimethyl-

68133-79-9 Apritone 0.00062000

2,6-octadien-l-yl)- l,6,10-Dodecatrien-3-ol, 3,7,11-

7212-44-4 Nerolidol 0.00061600 trimethyl-

2-Pentenenitrile, 3-methyl-5-

53243-59-7 Citronitril 0.00061500 phenyl-, (2Z)-

Benzenepropanenitrile, 4-ethyl-a,

134123-93-6 Fleuranil 0.00057600 a-dimethyl-

* Vapor Pressures were acquired from Scifinder, which utilizes the ACD Software V.11.02, as described in the Test Methods Section.

** Origin: The low volatile fragrance materials may be obtained from one or more of the following companies: Firmenich (Geneva, Switzerland), Symrise AG (Holzminden, Germany), Givaudan (Argenteuil, France), IFF (Hazlet, New Jersey), Bedoukian (Danbury, Connecticut), Sigma Aldrich (St. Louis, Missouri), Millennium Speciality Chemicals (Olympia Fields, Illinois), Polarone International (Jersey City, New Jersey), and Aroma & Flavor Specialities (Danbury, Connecticut).

In one embodiment, the compositions of the present invention are those wherein the low volatile fragrance materials comprise at most about 30 wt%, preferably at most about 28 wt%, preferably at most about 25 wt%, preferably at most about 22 wt%, preferably at most about 20 wt%, preferably at most about 18 wt%, preferably at most about 15 wt „ or alternatively combinations thereof, relative to the total weight of the fragrance component. Exemplary low volatile fragrance materials selected from the group consisting of the ingredients mentioned in Table 1 are preferred. However, it is understood by one skilled in the art that other low volatile fragrance materials, not recited in Table 1, would also fall within the scope of the present invention, so long as they have a vapor pressure < 0.001 Torr at 25°C.

In another aspect, the compositions of the present invention further comprises one or more volatile fragrance material having a vapor pressure > 0.001 Torr at 25°C (according to the reference program Advanced Chemistry Development (ACD/Labs) Software Version 11.02, (© 1994-2013)). Examples of volatile fragrance materials are listed in the Table 2 hereinafter.

Table 2 -Volatile Fragrance Materials for Use in the Compositions

CAS Vapor Pressure Number Chemical name Common Name**

(Torr at 25°C)*

107-31-3 Formic acid, methyl ester Methyl Formate 732.00000000

Dimethyl Sulfide 1.0% In

75-18-3 647.00000000

Methane, l,l'-thiobis- DEP

141-78-6 Acetic acid ethyl ester Ethyl Acetate 112.00000000

105-37-3 Propanoic acid, ethyl ester Ethyl Propionate 44.50000000

Acetic acid, 2-methylpropyl

110-19-0 Isobutyl Acetate 18.00000000 ester

105-54-4 Butanoic acid, ethyl ester Ethyl Butyrate 13.90000000

14765-30-1 1-Butanol Butyl Alcohol 8.52000000

Butanoic acid, 2-methyl-,

7452-79-1 Ethyl-2-Methyl Butyrate 7.85000000

ethyl ester

1-Butanol, 3-methyl-, 1-

123-92-2 Iso Amyl Acetate 5.68000000

acetate

Butanoic acid, 2-methyl-, 1-

66576-71-4 Iso Propyl 2-Methylbutyrate 5.10000000

methylethyl ester

110-43-0 2-Heptanone Methyl Amyl Ketone 4.73000000

6728-26-3 2-Hexenal, (2E)- Trans-2 Hexenal 4.62000000 123-51-3 1-Butanol, 3-methyl- Isoamyl Alcohol 4.16000000

2-Buten-l-ol, 3-methyl-, 1-

1191-16-8 Prenyl acetate 3.99000000 acetate

l,3-Dioxolane-2-

57366-77-5 Methyl Dioxolan 3.88000000 methanamine, N-methyl-

Bicyclo[3.1.1]hept-2-ene, 2,6,

7785-70-8 Alpha Pinene 3.49000000

6-trimethyl-, (1R,5R)-

Bicyclo[2.2.1]heptane, 2,2-

79-92-5 Camphene 3.38000000 dimethyl- 3 -methylene-

2-Butanethiol, 4-methoxy-2- 4-Methoxy-2-Methyl-2-

3.31000000

94087-83-9 methyl- Butanenthiol

Pentanoic acid, 2-methyl-,

39255-32-8 Manzanate 2.91000000 ethyl ester

Bicyclo[3.1.0]hexane, 4-

3387-41-5 Sabinene 2.63000000 methylene- 1 - ( 1 -methylethyl) -

Bicyclo[3.1.1]heptane, 6,6-

127-91-3 Beta Pinene 2.40000000 dimethyl-2-methylene-

1-Butanol, 3-methyl-, 1-

105-68-0 Amyl Propionate 2.36000000 propanoate

1,6-Octadiene, 7-methyl-3-

123-35-3 Myrcene 2.29000000 methylene-

124-13-0 Octanal Octyl Aldehyde 2.07000000

2H-Pyran, 2-

7392-19-0 ethenyltetrahydro-2,6,6- Limetol 1.90000000 trimethyl-

111-13-7 2-Octanone Methyl Hexyl Ketone 1.72000000

123-66-0 Hexanoic acid, ethyl ester Ethyl Caproate 1.66000000

2-Oxabicyclo[2.2.2]octane, 1,

470-82-6 Eucalyptol 1.65000000

3,3-trimethyl-

Benzene, l-methyl-4-(l-

99-87-6 Para Cymene 1.65000000 methylethyl)-

Benzene, l-methoxy-4-

104-93-8 Para Cresyl Methyl Ether 1.65000000 methyl-

1,3,6-Octatriene, 3,7-

13877-91-3 Ocimene 1.56000000 dimethyl-

Cyclohexene, l-methyl-4-(l-

138-86-3 dl-Limonene 1.54000000 methylethenyl)-

Cyclohexene, l-methyl-4-(l-

5989-27-5 d-limonene 1.54000000 methylethenyl)-, (4R)-

106-68-3 3-Octanone Ethyl Amyl Ketone 1.50000000

Methyl Nonyl

110-41-8 Undecanal, 2-methyl- 1.43000000

Acetaldehyde

142-92-7 Acetic acid, hexyl ester Hexyl acetate 1.39000000

110-93-0 5-Hepten-2-one, 6-methyl- Methyl Heptenone 1.28000000

81925-81-7 2-Hepten-4-one, 5-methyl- Filbertone 1% in TEC 1.25000000

3681-71-8 3-Hexen-l-ol, 1 -acetate, (3Z)- cis-3-Hexenyl acetate 1.22000000

Propanoic acid, 2-hydroxy-,

97-64-3 Ethyl Lactate 1.16000000 ethyl ester 4-Heptanol, 2,6-dimethyl-, 4-

10250-45-0 Alicate 0.45400000 acetate

Hexanoic acid, 2-

105-79-3 Iso Butyl Caproate 0.41300000 methylpropyl ester

Propanoic acid, 2-methyl-,

2349-07-7 Hexyl isobutyrate 0.41300000 hexyl ester

Cyclohexanecarboxylic acid,

23250-42-2 1,4-dimethyl-, methyl ester, Cyprissate 0.40500000 trans-

122-78-1 Benzeneacetaldehyde Phenyl acetaldehyde 0.36800000

Butanoic acid, 3 -hydroxy-,

5405-41-4 Ethyl-3-Hydroxy Butyrate 0.36200000 ethyl ester

Propanedioic acid, 1,3-diethyl

105-53-3 Diethyl Malonate 0.34400000 ester

93-58-3 Benzoic acid, methyl ester Methyl Benzoate 0.34000000

16356-11-9 1,3,5-Undec atriene Undecatriene 0.33600000

65405-70-1 4-Decenal, (4E)- Decenal (Trans-4) 0.33100000

1,3-Dioxane, 2-butyl-4,4,6-

54546-26-8 Herboxane 0.33000000 trimethyl-

13254-34-7 2-Heptanol, 2,6-dimethyl- Dimethyl-2 6-Heptan-2-ol 0.33000000

98-86-2 Ethanone, 1-phenyl- Acetophenone 0.29900000

Benzeneacetaldehyde, a-

93-53-8 Hydratropic aldehyde 0.29400000 methyl-

Propanoic acid, 2-methyl-, 1,

80118-06-5 Iso Pentyrate 0.28500000

3-dimethyl-3-buten-l-yl ester

557-48-2 2,6-Nonadienal, (2E,6Z)- E Z-2,6-Nonadien-l-al 0.28000000

Pyrazine, 2-methoxy-3-(2- 2-Methoxy-3-Isobutyl

24683-00-9 0.27300000 methylpropyl)- Pyrazine

Formic acid, phenylmethyl

104-57-4 Benzyl Formate 0.27300000 ester

Benzene, l-methoxy-4-

104-45-0 Dihydroanethole 0.26600000 propyl-

Cyclohexanone, 5-methyl-2-

491-07-6 Iso Menthone 0.25600000

(1-methylethyl)-, (2R,5R)-rel-

Cyclohexanone, 5-methyl-2-

89-80-5 Menthone Racemic 0.25600000

(1-methylethyl)-, (2R,5S)-rel-

2463-53-8 2-Nonenal 2 Nonen-l-al 0.25600000

Cyclohexanone, 2-ethyl-4,4-

55739-89-4 Thuyacetone 0.25000000 dimethyl-

Hydroquinone Dimethyl

150-78-7 Benzene, 1,4-dimethoxy- 0.25000000

Ether

Benzene, l-(ethoxymethyl)-2-

64988-06-3 Rosacene 0.24600000 methoxy- Bicyclo[2.2. l]heptan-2-one,

76-22-2 Camphor gum 0.22500000

1,7,7-trimethyl-

2-Hexene, 6,6-dimethoxy-2,5,

67674-46-8 Methyl pamplemousse 0.21400000

5-trimethyl-

112-31-2 Decanal Decyl Aldehyde 0.20700000

16251-77-7 Benzenepropanal, β-methyl- Trifernal 0.20600000

Benzenemethanol, a- methyl-, Methylphenylc arbinol

93-92-5 0.20300000

1 -acetate acetate

143-13-5 Acetic acid, nonyl ester Nonyl Acetate 0.19700000

122-00-9 Ethanone, l-(4-methylphenyl)- Para Methyl Acetophenone 0.18700000

2H-Pyran, 6-butyl-3,6-

24237-00-1 Gyrane 0.18600000 dihydro-2,4-dimethyl-

Propanoic acid, 2-methyl-,

41519-23-7 Hexenyl isobutyrate 0.18200000

(3Z)-3-hexen-l-yl ester

93-89-0 Benzoic acid, ethyl ester Ethyl Benzoate 0.18000000

3-Octanol, 3,7-dimethyl-, 3-

20780-48-7 Tetrahydro Linalyl Acetate 0.18000000 acetate

1-Hexanol, 5-methyl-2-(l- Tetrahydro Lavandulyl

40853-55-2 0.17300000 methylethyl)-, 1 -acetate Acetate

Cyclohexanol, 3,3,5-

933-48-2 Trimethylcyclohexanol 0.17300000 trimethyl-, (lR,5R)-rel-

2-Hexenal, 5-methyl-2-(l-

35158-25-9 Lactone of Cis Jasmone 0.17200000 methylethyl)-

18479-58-8 7-Octen-2-ol, 2,6-dimethyl- Dihydromyrcenol 0.16600000

Acetic acid, phenylmethyl

140-11-4 Benzyl acetate 0.16400000 ester

Cyclohexanone, 2-(l- 2-sec-Butyl Cyclo

14765-30-1 0.16300000 methylpropyl)- Hexanone

20125-84-2 3-Octen-l-ol, (3Z)- Octenol 0.16000000

Heptanoic acid, 2-propen-l-yl

142-19-8 Allyl Heptoate 0.16000000 ester

100-51-6 Benzenemethanol Benzyl Alcohol 0.15800000

Butanoic acid, 2-methyl-,

10032-15-2 Hexyl-2-Methyl Butyrate 0.15800000 hexyl ester

2(3H)-Furanone, 5-

695-06-7 Gamma Hexalactone 0.15200000 ethyldihydro-

Cyclohexaneethanol, 1-

21722-83-8 Cyclohexyl Ethyl Acetate 0.15200000 acetate

111-79-5 2-Nonenoic acid, methyl ester Methyl-2-Nonenoate 0.14600000

Butanoic acid, (3Z)-3-hexen-

16491-36-4 Cis 3 Hexenyl Butyrate 0.13500000

1-yl ester

111-12-6 2-Octynoic acid, methyl ester Methyl Heptine Carbonate 0.12500000

Cyclohexanecarboxylic acid,

22471-55-2 2,2,6-trimethyl-, ethyl ester, Thesaron 0.07670000

(lR,6S)-rel-

60-12-8 Benzeneethanol Phenethyl alcohol 0.07410000

2,6-Octadienal, 3,7-dimethyl-,

106-26-3 Neral 0.07120000

(2Z)-

5392-40-5 2,6-Octadienal, 3,7-dimethyl- Citral 0.07120000

Cyclohexanol, 5-methyl-2-(l-

89-48-5 methylethyl)-, 1-acetate, (1R, Menthyl Acetate 0.07070000

2S,5R)-rel-

Benzoic acid, 2-hydroxy-,

119-36-8 Methyl salicylate 0.07000000 methyl ester

Benzene, l-methoxy-4-(lE)-

4180-23-8 Anethol 0.06870000

1-propen-l-yl-

2,6-Octadiene, 1,1-

7549-37-3 Citral Dimethyl Acetal 0.06780000 dimethoxy- 3 ,7 -dimethyl-

Cyclohexanemethanol, a,3,3-

25225-08-5 Aphermate 0.06780000 trimethyl-, 1 -formate

3913-81-3 2-Decenal, (2E)- 2-Decene-l-al 0.06740000

3-Cyclopentene- 1-acetonitrile,

15373-31-6 Cantryl ^® 0.06700000

2,2,3-trimethyl-

2-Cyclohexen-l-one, 2-

6485-40-1 methyl-5-( 1 -methylethenyl)-, Laevo carvone 0.06560000

(5R)-

Cyclohexanone, 4-(l,l-

16587-71-6 Orivone 0.06490000 dimethylpropyl)-

6, 10-Dioxaspiro[4.5]decane,

62406-73-9 8,8-dimethyl-7-(l- Opalal CI 0.06290000 methylethyl)-

2-Cyclohexen-l-one, 3-

3720-16-9 Livescone 0.06270000 methyl- 5 -propyl-

Benzonitrile, 4-(l-

13816-33-6 Cumin Nitrile 0.06230000 methylethyl)-

67019-89-0 2,6-Nonadienenitrile Violet Nitrile 0.06200000

Butanoic acid, 2-methyl-, (3Z) cis-3-Hexenyl Alpha

53398-85-9 0.06130000

-3-hexen-l-yl ester Methyl Butyrate

Benzene, 1-

16510-27-3 (cyclopropylmethyl)-4- Toscanol 0.05870000 methoxy-

111-80-8 2-Nonynoic acid, methyl ester Methyl Octine Carbonate 0.05680000

Acetic acid, 2-phenylethyl

103-45-7 Phenyl Ethyl Acetate 0.05640000 ester

Cyclohexanol, 2-(l,l-

13491-79-7 Verdol 0.05430000 dimethylethyl)-

7786-44-9 2,6-Nonadien-l-ol 2,6-Nonadien- 1 -ol 0.05370000

Propanoic acid, 2-methyl-,

103-28-6 Benzyl Iso Butyrate 0.05130000 phenylmethyl ester

Furan, tetrahydro-2,4-

82461-14-1 Rhubafuran ^® 0.03780000 dimethyl-4-phenyl-

Benzene, [2-(3-methylbutoxy)

56011-02-0 Phenyl Ethyl Isoamyl Ether 0.03690000 ethyl] -

Butanoic acid, phenylmethyl

103-37-7 Benzyl Butyrate 0.03660000 ester

Benzoic acid, 2-hydroxy-,

118-61-6 Ethyl salicylate 0.03480000 ethyl ester

Cyclohexanol, 4-(l,l-

98-52-2 Patchon 0.03480000 dimethylethyl)- l,6-Octadien-3-ol, 3,7-

115-99-1 Linalyl Formate 0.03440000 dimethyl-, 3-formate

112-54-9 Dodecanal Laurie aldehyde 0.03440000

53046-97-2 3,6-Nonadien-l-ol, (3Z,6Z)- 3,6 Nonadien-l-ol 0.03360000

76649-25-7 3,6-Nonadien- 1 -ol 3,6-Nonadien- 1 -ol 0.03360000

1975-78-6 Decanenitrile Decanonitrile 0.03250000

Cyclohexanol, 5-methyl-2-(l-

2216-51-5 L-Menthol 0.03230000 methylethyl)-, (1R,2S,5R)-

Propanoic acid, 2-methyl-, 4-

103-93-5 Para Cresyl iso-Butyrate 0.03120000 methylphenyl ester

Propanoic acid, 2-methyl-,

(1R,2S,4R)-1,7,7-

24717-86-0 Abierate 0.03110000 trimethylbicyclo[2.2. l]hept-2- yl ester, rel-

Acetaldehyde, 2- (4-

67845-46-9 Aldehyde XI 0.03090000 methylphenoxy) -

2-Butenoic acid, 2-methyl-,

67883-79-8 Cis-3-Hexenyl Tiglate 0.03060000

(3Z)-3-hexen-l-yl ester, (2E)-

Bicyclo [3.1.1 ]hept-2-ene-2-

33885-51-7 Pino Acetaldehyde 0.03040000 propanal, 6,6-dimethyl-

70214-77-6 2-Nonanol, 6,8-dimethyl- Nonadyl 0.03010000

Cyclohexanol, l-methyl-3-(2-

215231-33-7 Rossitol 0.02990000 methylpropyl)-

120-72-9 lH-Indole Indole 0.02980000

2463-77-6 2-Undecenal 2-Undecene-l-al 0.02970000

2H-Pyran-2-one, 4,6-

675-09-2 Levistamel 0.02940000 dimethyl-

3-Cyclohexene-l -methanol, a,

98-55-5 alpha- Terpineol 0.02830000 a,4-trimethyl-

3-Hepten-2-one, 3,4,5,6,6-

81786-73-4 Koavone 0.02750000 pentamethyl-, (3Z)-

2(3H)-Furanone, 5-

39212-23-2 Methyl Octalactone 0.02700000 butyldihydro-4-methyl-

7-Octen-2-ol, 2,6-dimethyl-,

53767-93-4 Dihydro Terpinyl Acetate 0.02690000

2-acetate

104-55-2 2-Propenal, 3-phenyl- Cinnamic Aldehyde 0.02650000 l,6-Octadien-3-ol, 3,7-

144-39-8 Linalyl Propionate 0.02630000 dimethyl-, 3-propanoate

l,6-Nonadien-3-ol, 3,7- 3,7-Dimethyl- 1 ,6-nonadien-

61931-80-4 0.02630000 dimethyl-, 3 -acetate 3-yl acetate

Cyclopentanone, 2,2,5-

65443-14-3 veloutone 0.02610000 trimethyl- 5 -pentyl-

2,6-Octadien-l-ol, 3,7-

141-12-8 Neryl Acetate 0.02560000 dimethyl-, 1-acetate, (2Z)-

2,6-Octadien-l-ol, 3,7-

105-87-3 Geranyl acetate 0.02560000 dimethyl-, 1-acetate, (2E)-

Methyl Nonyl

Undecane, l,l-dimethoxy-2-

68141-17-3 Acetaldehyde Dimethyl 0.02550000 methyl- Acetal

Benzenemethanol, a-

2206-94-2 Indocolore 0.02550000 methylene-, 1-acetate

123-11-5 Benzaldehyde, 4-methoxy- Anisic aldehyde 0.02490000

Cyclohexanol, 5-methyl-2-(l-

57576-09-7 methylethenyl)-, 1-acetate, Iso Pulegol Acetate 0.02480000

(1R,2S,5R)-

51566-62-2 6-Octenenitrile, 3,7-dimethyl- Citronellyl Nitrile 0.02470000

30385-25-2 6-Octen-2-ol, 2,6-dimethyl- Dihydromyrcenol 0.02440000

101-84-8 Benzene, l,l'-oxybis- Diphenyl Oxide 0.02230000

136-60-7 Benzoic acid, butyl ester 136-60-7 0.02170000

5,8-Methano-2H-l-

93939-86-7 benzopyran, 6- Rhuboflor 0.02120000 ethylideneoctahydro-

Cyclohexanepropanol, α,α-

83926-73-2 Coranol 0.02100000 dimethyl-

Benzenepropanal, yl-3-

125109-85-5 P-meth

Florhydral 0.02070000 (1-methylethyl)-

Benzenemethanol, 4-

104-21-2 Anisyl Acetate 0.02050000 methoxy-, 1-acetate

2563-07-7 Phenol, 2-ethoxy-4-methyl- Ultravanil 0.02030000

Benzene, [2-(l-

7493-57-4 Acetaldehyde 0.01990000 propoxyethoxy)ethyl] -

141-25-3 7-Octen-l-ol, 3,7-dimethyl- Rhodinol 0.01970000

Bicyclo[4.3.1]decane, 3- 3-Methoxy-7,7-dimethyl-

216970-21- methoxy-7,7-dimethyl- 10- 10-methylenebicyclo[4.3.1] 0.01960000 7

methylene- decane

Propanoic acid, 2-(l,l-

319002-92-1 dimethylpropoxy)-, propyl Sclareolate ^® 0.01960000 ester, (2S)-

Benzoic acid, 2-

85-91-6 Dimethyl anthranilate 0.01930000

(methylamino)-, methyl ester

6-Octen-l-ol, 3,7-dimethyl-,

7540-51-4 L-Citronellol 0.01830000

(3S)-

7-Octen-2-ol, 2-methyl-6-

Myrcenol 0.01820000

543-39-5 methylene- 4,6-Octadien-3-ol, 3,7-

18479-54-4 Muguol 0.01800000 dimethyl-

5-Oxatricyclo[8.2.0.04,6]

1209-61-6 dodecane, 4,9,12,12- Tobacarol 0.01730000 tetramethyl-

2-Cyclohexene- 1 -carboxylic

57934-97-1 acid, 2-ethyl-6,6-dimethyl-, Givescone 0.01710000 ethyl ester

3-Buten-2-one, 4-(2,6,6-

79-77-6 trimethyl- 1-cyclohexen- 1-yl)-, beta-Ionone 0.01690000

(3E)-

4,7-Methano- lH-inden-5-ol,

64001-15-6 Dihydro Cyclacet 0.01630000 octahydro-, 5-acetate

Benzoic acid, 2-amino-,

134-20-3 Methyl anthranilate 0.01580000 methyl ester

Spiro[ 1 ,3-dioxolane-2,8'(5'H)- [2H-2,4a]

methanonaphthalene] ,

154171-77-4 Ysamber K ^® 0.01470000 hexahydro-r,r,5',5'- tetramethyl-, (2'S,4'aS,8'aS)- (9CI)

Spiro[ 1 ,3-dioxolane-2,8'(5'H)- [2H-

154171-76-3 2,4a] methanonaphthalene] , Ysamber 0.01470000 hexahydro-r,r,5',5'- tetramethyl-

3-Buten-2-one, 4-(2,6,6-

127-41-3 trimethyl-2-cyclohexen- 1-yl)-, alpha-Ionone 0.01440000

(3E)-

Benzeneethanol, α,α- Dimethyl Benzyl Carbinyl

151-05-3 0.01390000 dimethyl-, 1 -acetate Acetate

4,7-Methano- lH-inden-5-ol,

2500-83-6 3a,4,5,6,7,7a-hexahydro-, 5- Flor Acetate 0.01370000 acetate

6-Octen-l-ol, 3,7-dimethyl-,

150-84-5 Citronellyl acetate 0.01370000

1 -acetate

2H-Pyran, tetrahydro-2-

30310-41-9 methyl-4-methylene-6- Pelargene 0.01350000 phenyl-

Bicyclo[3.3.1]nonane, 2-

68845-00-1 ethoxy-2,6,6-trimethyl-9- Boisiris 0.01350000 methylene-

2,6-Octadien-l-ol, 3,7-

106-24-1 Geraniol 0.01330000 dimethyl-, (2E)-

Bicyclo[7.2.0]undec-4-ene, 4,

75975-83-6 11,1 l-trimethyl-8-methylene-, Vetyvenal 0.01280000

(1R,4E,9S)- lH-3a,7-Methanoazulene,

octahydro-6-methoxy-3,6,8,8-

19870-74-7 Cedryl methyl ether 0.01280000 tetramethyl-, (3R,3aS,6S,7R,

8aS)-

Bicyclo[7.2.0]undec-4-ene, 4,

87-44-5 11,1 l-trimethyl-8-methylene-, Caryophyllene Extra 0.01280000

(1R,4E,9S)- lH-Inden-l-one, 2,3-dihydro-

54440-17-4 Safraleine 0.01260000

2,3,3-trimethyl-

110-98-5 2-Propanol, l,l'-oxybis- Ambrocenide 0.01250000

2-Octanol, 7-methoxy-3,7-

41890-92-0 Osyrol ^® 0.01250000 dimethyl-

71077-31-1 4,9-Decadienal, 4,8-dimethyl- Floral Super 0.01230000

65-85-0 Benzoic Acid Benzoic Acid 0.01220000

3-Hexenoic acid, (3Z)-3- cis-3-hexenyl-cis-3-

61444-38-0 0.01220000 hexen-l-yl ester, (3Z)- hexenoate

Bicyclo[2.2. l]hept-5-ene-2- carboxylic acid, 3-(l-

116044-44-1 Herbanate 0.01210000 methylethyl)-, ethyl ester,

(lR,2S,3S,4S)-rel-

104-54-1 2-Propen-l-ol, 3-phenyl- Cinnamic alcohol 0.01170000

Propanoic acid, 2-methyl-, 1-

78-35-3 ethenyl- 1 ,5-dimethyl-4- Linalyl isobutyrate 0.01170000 hexen-l-yl ester

Ethanol, 2-phenoxy-, 1-

23495-12-7 Phenoxy Ethyl Propionate 0.01130000 propanoate

2-Propenoic acid, 3 -phenyl-,

103-26-4 Methyl Cinnamate 0.01120000 methyl ester

Benzenepropanal, 2-ethyl-a,a-

67634-14-4 Florazon (ortho-isomer) 0.01110000 dimethyl-

5454-19-3 Propanoic acid, decyl ester N-Decyl Propionate 0.01100000

Benzene, l,2-dimethoxy-4-(l-

93-16-3 Methyl Iso Eugenol 0.01100000 propen-l-yl)-

81782-77-6 3-Decen-5-ol, 4-methyl- 4-Methyl-3-decen-5-ol 0.01070000

Phenol, 2-methoxy-4-(2-

97-53-0 Eugenol 0.01040000 propen-l-yl)-

1 ,3-Benzodioxole-5-

120-57-0 Heliotropin 0.01040000 carboxaldehyde

4826-62-4 2-Dodecenal 2 Dodecene-l-al 0.01020000

20407-84-5 2-Dodecenal, (2E)- Aldehyde Mandarin 0.01020000

Benzenepropanal, 4-methoxy-

5462-06-6 Canthoxal 0.01020000 a-methyl-

1 ,4-Cyclohexanedicarboxylic Dimethyl 1,4-

94-60-0 0.01020000 acid, 1,4-dimethyl ester cyclohexanedicarboxylate

2-Buten-l-one, l-(2,6,6-

57378-68-4 delta-damascone 0.01020000 trimethyl-3-cyclohexen- 1-yl)-

2-Butanone, 4-(2,6,6-

17283-81-7 Dihydro Beta Ionone 0.01020000 trimethyl- 1 -cyclohexen- 1 -yl)- 2-Propenenitrile, 3-phenyl-,

1885-38-7 Cinnamalva 0.01010000

(2E)-

Propanoic acid, 2-methyl-, 2-

103-48-0 Phenyl Ethyl Iso Butyrate 0.00994000 phenylethyl ester

2-Cyclopenten-l-one, 3-

488-10-8 Cis Jasmone 0.00982000 methyl-2-(2Z)-2-penten- 1-yl-

Acetaldehyde, 2-[(3,7-

7492-67-3 Citronellyloxyacetaldehyde 0.00967000 dimethyl-6-octen- l-yl)oxy]-

1 -Cyclohexene- 1 -ethanol, 4-

68683-20-5 Iso Bergamate 0.00965000

(1-methylethyl)-, 1 -formate

2,4-Decadienoic acid, ethyl

3025-30-7 Ethyl 2,4-Decadienoate 0.00954000 ester, (2E,4Z)-

2-Propen-l-ol, 3-phenyl-, 1-

103-54-8 Cinnamyl Acetate 0.00940000 acetate

Naphtho[2,l-b]furan,

dodecahydro-3a,6,6,9a-

6790-58-5 Synambran 0.00934000 tetramethyl-, (3aR,5aS,9aS,

9bR)-

Benzenepropanal, 4-(l,l-

18127-01-0 Bourgeonal 0.00934000 dimethylethyl)-

Naphtho[2,l-b]furan,

3738-00-9 dodecahydro-3a,6,6,9a- Ambroxan 0.00934000 tetramethyl- l,4-Methanonaphthalen-5(lH)

51519-65-4 -one, 4,4a,6,7,8,8a- Tamisone 0.00932000 hexahydro-

Dodecanoic acid, ^-hydroxy¬

148-05-1 s Dodecalactone 0.00931000

-lactone (6CI,7CI); 1,12-

Cyclohexanepropanoic acid, Allyl Cyclohexane

2705-87-5 0.00925000

2-propen-l-yl ester Propionate

2(3H)-Furanone, 5-

7011-83-8 Lactojasmone ^® 0.00885000 hexyldihydro-5-methyl-

2,6-Nonadienenitrile, 3,7-

61792-11-8 Lemonile ^® 0.00884000 dimethyl-

10-Undecenoic acid, ethyl

692-86-4 Ethyl Undecylenate 0.00882000 ester

Benzenepropanal, a-methyl-4-

103-95-7 Cymal 0.00881000

(1-methylethyl)- l-Oxaspiro[4.5]decan-2-one,

94201-19-1 Methyl Laitone 10% TEC 0.00872000

8-methyl-

2(3H)-Furanone, dihydro-5-

104-61-0 γ-Nonalactone 0.00858000 pentyl-

2(3H)-Furanone, 5-

706-14-9 γ -Decalactone 0.00852000 hexyldihydro-

2-Buten-l-one, l-(2,6,6-

24720-09-0 trimethyl-2-cyclohexen- 1-yl)-, a-Damascone 0.00830000

(2E)- 2-Buten-l-one, l-(2,4,4-

39872-57-6 trimethyl-2-cyclohexen- 1-yl)-, Isodamascone 0.00830000

(2E)-

2H-Pyran-2-one, tetrahydro-

705-86-2 Decalactone 0.00825000

6-pentyl-

Benzenepropanal, 4-ethyl-a,a-

67634-15-5 Floralozone 0.00808000 dimethyl-

1,3-Benzodioxole, 5-

40527-42-2 Heliotropin Diethyl Acetal 0.00796000

(diethoxymethyl)-

4-Penten-l-one, l-(5,5-

56973-85-4 Neobutenone a 0.00763000 dimethyl- 1 -cyclohexen- 1 -yl)-

Bicyclo [3.1.1 ]hept-2-ene-2-

128-51-8 ethanol, 6,6-dimethyl-, 2- Nopyl Acetate 0.00751000 acetate

2-Propenoic acid, 3 -phenyl-,

103-36-6 Ethyl Cinnamate 0.00729000 ethyl ester

1,3-Dioxane, 2,4,6-trimethyl-

5182-36-5 Floropal ^® 0.00709000

4-phenyl-

Cyclododecane,

42604-12-6 Boisambrene 0.00686000

(methoxymethoxy)-

Bicyclo [3.1.1 ]hept-2-ene-2-

33885-52-8 Pinyl Iso Butyrate Alpha 0.00685000 propanal, a,a,6,6-tetramethyl-

Benzeneacetonitrile, 4-(l,l-

3288-99-1 Marenil CI 0.00665000 dimethylethyl)-

2-Buten-l-one, l-(2,6,6-

35044-68-9 beta-Damascone 0.00655000 trimethyl- 1 -cyclohexen- 1 -yl)-

1 ,4-Methanonaphthalen-6(2H)

41724-19-0 Plicatone 0.00652000

-one, octahydro-7-methyl-

Bicyclo[3.2.1]octan-8-one, 1,

75147-23-8 Buccoxime ^® 0.00647000

5 -dimethyl-, oxime

Cyclohexene, 4-(l,5-

495-62-5 dimethyl-4-hexen- 1 -ylidene)- Bisabolene 0.00630000

1 -methyl-

2785-87-7 Phenol, 2-methoxy-4-propyl- Dihydro Eugenol 0.00624000

Benzoic acid, 2-hydroxy-, 2-

87-19-4 Iso Butyl Salicylate 0.00613000 methylpropyl ester

2H- l-Benzopyran-2-one,

4430-31-3 Octahydro Coumarin 0.00586000 octahydro-

Cyclohexanone, 2-(l-

38462-22-5 mercapto- 1 -methylethyl)-5- Ringonol 50 TEC 0.00585000 methyl-

2-Oxiranecarboxylic acid, 3-

77-83-8 Ethylmethylphenylglycidate 0.00571000 methyl- 3 -phenyl-, ethyl ester

3 -Cyclohexene- 1 -

Iso Hexenyl Cyclohexenyl

37677-14-8 carboxaldehyde, 4-(4-methyl- 0.00565000

Carboxaldehyde

3-penten-l-yl)-

Propanoic acid, 2-methyl-, 2-

103-60-6 Phenoxy Ethyl iso-Butyrate 0.00562000 phenoxyethyl ester

* Vapor Pressures were acquired from Scifinder, which utilizes the ACD Software V.11.02, as described in the Test Methods Section.

** Origin: The low volatile fragrance materials may be obtained from one or more of the following companies: Firmenich (Geneva, Switzerland), Symrise AG (Holzminden, Germany), Givaudan (Argenteuil, France), IFF (Hazlet, New Jersey), Bedoukian (Danbury, Connecticut), Sigma Aldrich (St. Louis, Missouri), Millennium Speciality Chemicals (Olympia Fields, Illinois), Polarone International (Jersey City, New Jersey) and Aroma & Flavor Specialities (Danbury, Connecticut). It is understood by one skilled in the art that other volatile fragrance materials, not recited in Table 2, would also fall within the scope of the present invention, so long as they have a vapor pressure of > 0.001 Torr at 25°C.

Modulators & Co-Modulators

In one aspect, compositions of the present invention comprise at least one non-odorous modulator formed from an alkoxylated glucoside, preferably selected from non-limiting example of the group consisting of methyl glucoside polyol, ethyl glucoside polyol and propyl glucoside polyol. The modulator is a compound of formula I):

wherein:

R ¹ is hydrogen, alkyl, alkenyl or alkynyl;

2 6 7 8 9

R is selected from hydrogen, alkyl, alkenyl, alkynyl, -[R R (R )0] _W R ,wherein w is from 1 to 10, preferably 2 to 9;

3 6 7 8 9

R is selected from hydrogen, alkyl, alkenyl, alkynyl, -[R R (R )0] _y R ,wherein y is from 1 to 10, preferably 2 to 9;

R ⁴ is selected from hydrogen, alkyl, alkenyl, alkynyl, -[R ⁶ R ⁷ (R ⁸ )0] _x R ⁹ ,wherein x is from 1 to 10, preferably 2 to 9;

R ⁵ is selected from hydrogen, alkyl, alkenyl, alkynyl, -R ⁶ OR ⁹ , -R ⁶ 0[R ⁶ R ⁷ (R ⁸ )0] _z R ⁹ , wherein z is from 1 to 10, preferably 2 to 9;

each R ⁶ and R ⁷ are independently selected from alkylene, alkenylene, or alkynylene; and

8 9

each R and R is independently selected from hydrogen or alkyl,

In an embodiment of formula (I), wherein the sum of w, y, x and z is equal to 4 to 40, preferably 8 to 36, more preferably 10 to 32, more preferably 10 to 28, or combinations thereof.

Preferably, the modulator is Undecyl Glucoside and is available under the tradename Simulsol ^® SL 11 W from SEPPIC, France. In another embodiment of formula (I), the modulator is a compound of formula (la):

In an embodiment of formula (la), wherein w + x + y + z is equal to 4 to 40, preferably 8 to 36, more preferably 10 to 32, more preferably 10 to 28, or combinations thereof. Preferably, the modulator is a PPG- 10 Methyl Glucose Ether available under the tradename Glucam™ P-10 or Ethoxylated Methyl Glucose Ether and is available under the tradename Glucam™ E-20, respectively, from Lubrizol (USA). More preferably, the modulator is a PPG-20 Methyl Glucose Ether, and is available under the tradename Glucam™ P-20 from Lubrizol (USA).

In an embodiment, th II):

wherein:

Pv ¹⁰ is hydrogen, alkyl, alkenyl or alkynyl;

each R ¹¹ is independently selected from hydrogen, alkyl, alkenyl, alkynyl;

each R 12 is independently selected from hydrogen, alkyl, alkenyl, or alkynyl;

each R 13 is independently selected from hydrogen, alkyl, alkenyl, or alkynyl;

each R ¹⁴ is selected from alkylene, alkenylene, or alkynylene; and

R ¹⁵ is hydrogen, alkyl, alkenyl or alkynyl;

wherein t is 5 or less, preferably 1, 2 or 3.

Preferably, the modulator of formula (II) is Caprylyl/Capryl Glucoside and is available under the tradename Plantacare ^® 810 UP from BASF, Ludwigshafen, Germany.

The inventors discovered that the alkoxylated glucoside acts as a modulator of the perceived intensity and/or longevity of the fragrance profile of the composition of the present invention when low levels of the low volatile fragrance materials are used. For example, the modulators act to prolong the duration during which the fragrance profile can be perceived as compared to a control composition in the absence of the modulators. As another example, the modulators can improve the intensity of the fragrance profile such that it remains significantly the same from initial impression to the end as compared to a control composition.

While not wishing to be bound by theory, it is believed that the modulators associate to the fragrance materials and retard evaporation.

In another aspect, compositions of the present invention further comprise one or more non-odorous fragrance co-modulators. The fragrance co-modulators consist of substances capable of increasing the intensity and/or longevity of the fragrance profile, and therefore of the composition, as compared to control composition absent the co-modulators. In one embodiment, the non-odorous fragrance co-modulators are selected from the group consisting of:

(i) Isocetyl alcohol (CERAPHYL ^® ICA);

(ii) PPG-3 myristyl ether (preferably Tegosoft™ APM and/or Varonic ^® APM);

(iii) Neopentyl glycol diethylhexanoate (preferably Schercemol™ NGDO ); and

(iv) mixture thereof preferably with isocetyl alcohol (CERAPHYL ^® ICA).

PPG-3 myristyl ether is commercialized by various suppliers including:

(i) Evonik-Goldschmidt under the tradename Tegosoft™ APM;

(ii) Degussa under the tradename Varonic ^® APM;

(iii) International Speciality Products as a mixture of PPG-3 myristyl ether with isocetyl alcohol;

(iv) Lubrizol Advanced Materials (USA) as a mixture of PPG-3 myristyl ether with neopentyl glycol diethylhexanoate under the tradename Schercemol™ NGDO ester; and

(v) combinations thereof.

However, any such commercial forms of PPG-3 myristyl ether and mixtures thereof, are appropriate for use as co-modulators in the compositions of the present invention.

The composition comprises the non-odorous fragrance co-modulators present in an amount of from about 0.05 wt to about 10 wt%, preferably from about 0.5 wt to about 6 wt%, or combinations thereof, relative to the total weight of the composition. Alternatively, the non- odorous fragrance co-modulators is present in an amount of from about 0.05 wt or 0.5 wt to about 6 wt or 10 wt%, relative to the total weight of the composition. Preferably, the non- odorous fragrance co-modulator exist as mixtures of PPG-3 myristyl ether together with CERAPHYL ^® ICA and Schercemol™ NGDO ester, wherein the PPG-3 myristyl ether is 50 wt% and the other two components thereof are present in equal wt in the mixture, wherein the wt is the total weight of all the co-modulators in the composition. In particular, mixtures of PPG-3 myristyl ether with CERAPHYL ^® ICA, in a 1: 1 weight ratio, is preferred (PCT Publication No. WO2013/064412 (Firmenich)).

In another embodiment, the co-modulators exist as mixtures of Neopentyl Glycol Diethylhexanoate together with CERAPHYL ^® ICA, wherein the Neopentyl Glycol Diethylhexanoate is 50 wt and CERAPHYL ^® ICA is 50 wt in the compositions are useful. Similarly, compositions of the present invention that contain at least 50 wt of Schercemol™ NGDO ester together with Tegosoft™ APM also proved to be useful to prolong the perception of the fragrance profile from the substrate on which it has been applied, as compared to control compositions (PCT Publication No. WO2013/060691 (Firmenich)).

It is understood that the addition of the co-modulators is intended to further improve the intensity and/or longevity of the fragrance profile of the composition above the improvement already provided for by the modulators. Preferably, at least 50 wt of the non-odorous fragrance modulator is PPG-20 Methyl Glucose Ether, with the remainder to 100 wt possibly being one or more other modulators or co-modulators.

In yet another aspect, compositions of the present invention comprises one or more non- odorous fragrance co-modulators selected from the group consisting of:

(v) Isocetyl alcohol (CERAPHYL ^® ICA);

(vi) PPG-3 myristyl ether (preferably Tegosoft™ APM and/or Varonic ^® APM);

(vii) Neopentyl glycol diethylhexanoate (preferably Schercemol™ NGDO ); and

(viii) mixture thereof preferably with isocetyl alcohol (CERAPHYL ^® ICA). and being essentially free of non-odorous modulators formed from an alkoxylated glucoside selected from the group consisting of methyl glucoside polyol, ethyl glucoside polyol and propyl glucoside polyol. As used herein, the term "essentially free" means that the composition is free of that ingredient or no ingredient is intended to be added to the composition.

In an embodiment, a composition comprising:

(i) a fragrance component present in an amount of from about 0.04 wt to about 30 wt%, preferably 1 wt to about 30 wt%, preferably less than about 25 wt%, preferably less than about 20 wt%, preferably less than about 15 wt%, preferably less than about 10 wt or preferably less than 8 wt%, relative to the total weight of the composition; and wherein:

(a) the fragrance component comprises at least one low volatile fragrance material having a vapor pressure < 0.001 Torr at 25°C; and

(b) the low volatile fragrance material is present in an amount of from about 0.1 wt to about 30 wt%, preferably less than about 28 wt%, preferably less than about 25 wt%, preferably less than about 22 wt%, preferably less than 20 wt%, preferably less than 18 wt%, or preferably less than 15 wt%, relative to the total weight of the fragrance component;

(ii) one or more non-odorous fragrance co-modulators selected from the group consisting of:

(a) Isocetyl alcohol (CERAPHYL ^® ICA);

(b) PPG-3 myristyl ether (preferably Tegosoft™ APM and/or Varonic ^® APM);

(c) Neopentyl glycol diethylhexanoate (preferably Schercemol™ NGDO ); and (d) mixture thereof preferably with isocetyl alcohol (CERAPHYL ^® ICA);

wherein the co-modulators are present in an amount of from about 0.05 wt% or 0.5 wt% to about 6 wt% or 10 wt%, relative to the total weight of the composition

TEST METHODS

The following assays set forth must be used in order that the invention described and claimed herein may be more fully understood.

Test Method 1: Determining Vapor Pressure

In order to determine the vapor pressure for the fragrance materials, go to the website https://scifinder.cas.org/scifinder/view/scifinder/scifinder Explore.jsf and follow these steps to acquire the vapor pressure.

1. Input the CAS registry number for the particular fragrance material.

2. Select the vapor pressure from the search results.

3. Record the vapor pressure (given in Torr at 25°C).

SciFinder uses Advanced Chemistry Development (ACD/Labs) Software Version 11.02. (© 1994-2013). If the CAS number for the particular fragrance material is unknown or does not exist, you can utilize the ACD/Labs reference program to directly determine the vapor pressure. Test Method 2: Olfactory Tests

In order to show the effect of the modulators/co-modulators and low volatile fragrance materials on the perception of fragrance profile in a composition of the present invention, test compositions are made, as described in the Example section, and given to panelists to evaluate.

At the testing facility, 50 μΐ _^ samples of the compositions or the controls are applied to glass slides and placed on a hot plate at 32°C to represent skin temperature for varying durations. The panelists are asked to evaluate the perceived fragrance profile (intensity and/or character) from each pair of samples, i.e., that of the test composition of the present invention vs. the corresponding control, at time 0 and later time points (1, 2, 3 4 and 6 hours post application) as the fragrance profile evolves. Their assessments are recorded. Panelists are selected from individuals who are either trained to evaluate fragrances according to the scales below or who have experience of fragrance evaluation in the industry,

(a) Fragrance Intensity:

The panelists are asked to give a score on a scale of 1 to 5 for perceived fragrance intensity according to the odour intensity scale set out in Table 3 herein below.

Table 3 - Odour Intensity Scale

(b) Fragrance Character:

The panelists are asked to assess the fragrance character in one of 2 ways:

i) a score on a scale of 0 to 3 for the dominance of particular characters that are relevant to that particular fragrance, e.g.: floral, rose, muguet, fruity, apple, berry, citrus, woody, musk just to name a few, according to the odour grading scale set out in Table 4i herein below;

ii) a score on a scale of 1 to 5 for changes in the perceived fragrance character change for the test compositions versus the controls according to the odour grading scale set out in Table 4ii herein below. Table 4i - Character Dominance Odour Grading Scale

Table 4ii - Character Difference Odour Grading Scale

The results of the panelists are averaged and then analysed using Analysis of Variance methods. The model treats the subject as a random effect and looks at the impact of product, time and the interaction between product and time. From the analysis the least square means for the product and time interaction are obtained. These means (as well as their confidence intervals) are then plotted to enable comparisons between products at each time point. It should be noted that the confidence levels plotted are intended as a guide, and not as a statistical comparison, as they do not take into account that multiple testing has been performed. As well as a graphical assessment, statistical comparisons between the two products at each of the time points are performed with a Sidak correction for multiple comparisons. The p-values for the product differences were obtained, with p-values < 0.05 indicating a statistical difference between the two products at 5% significance (or 95% confidence). EXAMPLES

The following examples are provided to further illustrate the present invention and are not to be construed as limitations of the present invention, as many variations of the present invention are possible without departing from its spirit or scope.

Examples 1 to 6 - Fragrances

Examples la to 5 are non-limiting examples of formulations of fragrance materials intended to form the fragrance component of the compositions of the present invention. The exemplary formulations of the fragrance materials span the range from "simple accords" (<10 fragrance materials) to "complex fragrances" (> 30 fragrance materials). Typically, full bodied fragrance compositions do not comprise less than about 30 fragrance materials. Examples lb and 6 are examples of a formulation of fragrance materials intended to form the fragrance component that fall outside the scope of the present invention. The following fragrance formulations are made by mixing the listed ingredients in the listed proportions (wt%) at room temperature, wherein the wt is relative to the total weight of the fragrance component.

Table 5a - Example la - Fresh Floral Accord (Fragrance I - 8.00 wt Low Volatile Fragrance Materials)

Ingredients CAS Number Vapor Pressure Parts

(Torr at 25°C) (wt%)

Benzyl acetate 140-11-4 0.1640 11.0

Linalool 78-70-6 0.0905 10.0

Phenethyl alcohol 60-12-8 0.0741 16.0

Indole 120-72-9 0.0298 1.0

a-Terpineol 98-55-5 0.0283 3.0

Geranyl acetate 105-87-3 0.0256 5.0

Cymal 103-95-7 0.00881 6.0

Hydroxycitronellal 107-75-5 0.00318 23.0

Majantol 103694-68-4 0.00224 17.0

Hexyl cinnamic

101-86-0 0.000697 8.0

aldehyde Table 5b - Example lb - Traditional Floral Accord (Fragrance VII - 54.00 wt Low Volatile Fragrance Materials)

Table 6 - Example 2 - Floral Gourmand Accord (Fragrance II - 0.20 wt Low Volatile Fragrance Materials)

* Supplied at 10% in TEC. Table 7 - Example 3 - Woody Accord (Fragrance III - 7.00 wt% Low Volatile Fragrance Materials)

Table 8 - Example 4 - Fresh Male Accord (Fragrance IV - 13.51 wt% Low Volatile Fragrance Materials)

Supplied at 50% in Isopropyl myristate. Table 9 - Example 5 - Sweet Dream 18 Fragrance (Fragrance V - 11.15 wt Low Volatile Fragrance Materials)

Ingredients CAS Number Vapor Pressure Parts

(Torr at 25°C) (wt%)

Prenyl acetate 1191-16-8 3.99000000 0.100

Manzanate 39255-32-8 2.91000000 0.200

Hexyl acetate 142-92-7 1.39000000 0.700 cis-3-Hexenyl

3681-71-8 1.22000000 0.200 acetate

Benzaldehyde 100-52-7 0.97400000 0.200

Liffarome 67633-96-9 0.72100000 0.150

Hexyl isobutyrate 2349-07-7 0.41300000 0.055

Dihydromyrcenol 18479-58-8 0.16600000 2.500

Benzyl acetate 140-11-4 0.16400000 0.700

Linalyl acetate 115-95-7 0.11600000 2.500

Verdox 88-41-5 0.10300000 4.000

Phenethyl alcohol 60-12-8 0.07410000 8.000

Rossitol 215231-33-7 0.02990000 1.500 alpha- Terpineol 98-55-5 0.02830000 1.500

Geranyl acetate 105-87-3 0.02560000 1.500

Rhodinol 141-25-3 0.01970000 0.700

Givescone 57934-97-1 0.01710000 0.700

Methyl anthranilate 134-20-3 0.01580000 0.050

Ysamber K 154171-77-4 0.01470000 1.000 alpha-Ionone 127-41-3 0.01440000 3.000

Citronellyl acetate 150-84-5 0.01370000 0.500 cis-3-hexenyl-cis-3-

61444-38-0 0.01220000 0.200 hexenoate

Cinnamic alcohol 104-54-1 0.01170000 0.100 delta-damascone 57378-68-4 0.01020000 0.200

Citronellyloxyacetal

7492-67-3 0.00967000 0.100 dehyde

Cymal 103-95-7 0.00881000 0.500

Floralozone 67634-15-5 0.00808000 0.100

Ethylmethylphenylg

77-83-8 0.00571000 0.200 lycidate

Floras a Q 63500-71-0 0.00557000 3.000

Ethyl linalool 10339-55-6 0.00520000 6.400

Pivarose 67662-96-8 0.00484000 2.500

Hydroxycitronellal 107-75-5 0.00318000 7.500

Methyl Ionone 7779-30-8 0.00286000 4.000 gamma-

104-67-6 0.00271000 0.500

Undecalactone

² Supplied at 50% in DiPG.

Proprietary bases that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.

⁴ Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of high volatility for the purposes of calculating % of low volatility PRMs.

⁵ Proprietary bases that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs.

⁶ Natural oils or extracts that contain a mixture of perfume raw materials, judged to be of low volatility for the purposes of calculating % of low volatility PRMs. Table 10 - Example 6 - Fresh Floral GF 6-7 Accord (Fragrance VI - 40.14 wt Low Volatile Fragrance Materials)

Examples 7 - Compositions Comprising Fragrance Modulators

Compositions A, C, E, G, and L are examples of fine fragrance compositions according to the present invention, made with Fragrances I to V, respectively. They are prepared by admixture of the components described in Tables 11a, in the proportions indicated. In parallel, control Compositions B, D, F, H, and M, are prepared by replacing the non-odorous fragrance modulator, Glucam™ P-20, by the same amount of demineralized water. Additionally, Compositions I and N are examples of a fine fragrance composition comprising excessive levels of low volatile fragrance materials, and Compositions J and O are their corresponding controls, minus the non-odorous fragrance modulator, Glucam™ P-20. Composition K is an example of a fine fragrance composition of the present invention with both modulator and co-modulator.

Table 1 la - Fine Fragrance Compositions

5 Wt is relative to the total weight of the composition.

Compositions AA, BB, CC, DD, EE, FF, HH, II, and JJ are examples of fine fragrance compositions according to the present invention, made with Fragrances I, II and V the non- odorous fragrance modulators: Glucam™ P-10, Glucam™ E-10, and Glucam™ E-20, respectively. They are prepared by admixture of the components in Table 1 lb, in the proportions indicated. In parallel, Compositions GG and KK, are prepared by incorporating a non-odorous fragrance modulator and a co-modulator (Glucam™ P-10and Isocetyl alcohol CERAPHYL ICA) or two non-odorous fragrance modulators (Glucam™ P-10, Glucam™ P-20), respectively. 5 Table 1 lb - Fine Fragrance Compositions

Compositions b and d are examples of compositions according to the present invention, made with single perfume raw materials and the non-odorous modulators Simulsol SL 11W™ and Plantacare ^® 810 UP, respectively. They are prepared by admixture of the components in Table 11c, in the proportions indicated. In parallel, control Compositions a and c are prepared without a non-odorous modulator as a control.

Table 11c - Single Pefume Raw Material Compositions

Composition (wt%) ¹

Ingredients

a b c d

Phenethyl - -

1.0 1.0

alcohol

Cymal - - 1.0 1.0

Simulsol - 2.7 - - SL11W™ ²

Plantacare ^® - - - 2.5

810 UP ³

Ethanol 75

Demineralized

to 100

water Wt% is relative to the total weight of the composition.

Added as a 55 wt active solution in water.

Added as a 62 wt active solution in water.

Compositions P and Q are examples of body spray compositions according to the present invention. They are prepared by admixture of the components described in Table 12, in the proportions indicated.

Table 12 - Body Spray Compositions

wt% relative to the total weight of the composition

Can be any Fragrances I, II, or V.

Composition R is an example of body lotion composition according to the present invention. It is prepared by admixture of the components described in Table 13, in the proportions indicated. Table 13 - Body Lotion Composition

wt% relative to the total weight of the composition

Can be any Fragrances I, II, or V.

Example 8 - Odour Test

Compositions disclosed in Table 11a are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 9 expert panelists evaluated the perceived fragrance profile at intial time 0, then at various time points typically 1 hour, 2 hours, 3 hours, 4 hours and 6 hours post application,

(a) Compositions A vs. B:

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 1 shows the effect of the fragrance modulator and reduced levels of low volatile fragrance materials for compositions A and B on fragrance intensity. Fragrance intensity is maintained for up to 6 hours in the presence of the modulator whilst it drops in the absence of the modulator. The modulator acts to maintain the continued evaporation over time of the perfume materials. The effect of the improved fragrance strength of the present invention is noticeable at 3 hours and 6 hours with an indication of a statistical difference at 6 hours after application on the slides as indicated graphically by the confidence intervals. Statistical analysis using the Sidak corrections for multiple comparisons confirm the statistically significant difference between the 2 products at 6 hours at 5% significance level (p = 0.0008, i.e., p < 0.05).

Panellists are are also asked to score the composition for the dominance of the muguet character on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panel test are then averaged. Figure 2 shows the effect of the fragrance modulator and reduced levels of low volatile fragrance materials for compositions A and B on muguet character dominance. The muguet character is reduced by the modulator at the initial time point but is then released over the remainder of the time for up to at least 6 hours. The effect of the improved fragrance character over time of the compositions of the present invention are noticeable at 3 and 6 hours with an indication of a statistical difference at 6 hours after application on the slides as indicated by the confidence intervals. Statistical analysis using both the Sidak corrections for multiple comparisons confirm the statistically significant difference between the 2 products at 0 and 6 hours at 5% significance level (p = 0.0261 respectively, i.e., p < 0.05).

(b) Compositions C vs. D:

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 3 shows the effect of the fragrance modulator and reduced levels of low volatile fragrance materials for compositions C and D on fragrance intensity. Fragrance intensity is maintained for up to 6 hours in the presence of the modulator whilst it drops in the absence of the modulator. The modulator acts to maintain the continued evaporation over time of the perfume materials. The effect of the improved fragrance strength of the present invention is noticeable at 2 and 4 hours and significant at 6 hours after application on the slides as indicated graphically by the confidence intervals. Statistical analysis using the Sidak corrections for multiple comparisons confirm the statistically significant difference between the 2 products at 4 hours at 5% significance level (p=0.035, i.e., p < 0.05) and at 6 hours at 5% significance level (p = < 0.0001, i.e., p < 0.05).

Panellists are asked to score the compositions on a scale of 1 to 5, wherein 1 represents the perfume character remains unchanged and 5 represents a total change in the perfume character. The results of the panel test were averaged and plotted together with the confidence intervals. Figure 4 shows the effect of the fragrance modulator and reduced levels of low volatile fragrance materials for compositions C and D. The presence of the modulator results in noticeable changes in perfume character. Statistical analysis using the Sidak corrections for multiple comparisons confirm the statistically significant difference between the 2 products at 1 hour (p = 0.002, i.e., p < 0.05), 4 hours (p = 0.0003, i.e., p < 0.05) and 6 hours (p = < 0.001, i.e., p < 0.05) at 5% significance level.

Similar effects are observed for compositions E to H, and L to M (data not shown), (c) Compositions N and O

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 5 shows the effect of the fragrance modulator and excessive levels of low volatile fragrance materials for compositions N and O on fragrance intensity. Fragrance intensity is unaffected by the addition of the modulator. There are no statistical differences between the 2 products.

Panellists are also asked to score the composition for the dominance of the muguet character on a scale of 0 to 3 wherein 0 represents not detectable and 3 represents it being the dominant character. The results of the panel test are then averaged. Figure 6 shows the effect of the fragrance modulator and excessive levels of low volatile fragrance materials for compositions Nand O on muguet character dominance. The muguet character is perceived initially but then drops quickly over time. After 1 hour it is only slightly perceived and after 6 hours it is not present in either composition. Addition of the modulator does not result in prolonged release of the muguet character as was seen in compositions A and B. There are no statistical differences between the 2 products. (d) Compositions I and J

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 7 shows the effect of the fragrance modulator in the presence of execessive levels of low volatile fragrance materials for compositions I and J. The effects of the modulator is negated in more traditional fragrance composition where execessive amounts of the low volatile fragrance materials are present. The fragrance appears to be suppressed with a loss of strength. This is noticeable at all time points and appears significant as indicated graphically by the confidence intervals. Statistical analysis using the Sidak corrections for multiple comparisons confirm the statistically significant difference between the 2 products at time 0 (p = 0.0229, i.e., p < 0.05), at 1 hour (p = 0.0013, i.e., p < 0.05), at 3 hours (p = 0.0013, i.e., p < 0.05) and at 6 hours (p = 0.0003, i.e., p < 0.05) at 5% significance level.

Compositions disclosed in Table 11c are applied to glass slides in accordance with the protocol described in the Method Section and a panel of 8 expert panelists evaluated the perceived fragrance profile at intial time 0, then at various time points typically 1 hour, 3 hours, 5 hours and 6 hours post application.

(e) Compositions a vs. b:

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 8 shows the effect of the non-odourous fragrance modulator Simulsol SL11 W™ on phenethyl alcohol. Addition of the non-odorous fragrance modulator maintains the intensity of the perfume raw material from 1 hour up to 5 hours whilst the control compositions, in the absence of the non-odorous fragrance modulator, drops in intensity over the 5 hours. The non-odourous fragrance modulator acts to maintain the continued evaporation over time of the perfume material. Statistical analysis using the Tukey correction for multiple comparisons confirm the statistically significant difference at 1 hour at 90% significance level (p = 0.0933, i.e., p < 0.10). (f) Compositions c vs. d:

Panellists are asked to score the compositions for the intensity of the fragrance on a scale of 1 to 5, wherein 1 represents a low fragrance intensity is detected and 5 represents a very strong fragrance intensity is detected. The results of the panel test are then averaged. Figure 9 shows the effect of the fragrance modulator Plantacare ^® 810UP on Cymal. Addition of the modulator maintains the intensity of the perfume raw material from 1 hour up to 6 hours whilst the control, in the absence of the modulator, drops over the 6 hours. The modulator acts to maintain the continued evaporation over time of the perfume material. Statistical analysis using the Tukey correction for multiple comparisons confirms the statistically significant difference at 3 hours at 95% significance level (p = 0.0002, i.e., p < 0.05) and at 6 hours at 95% significance level (p 0.0022, i.e., p < 0.05).

It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification will include every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification will include every narrower numerical range that falls within such broader numerical range, as if such narrower numerical.

The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm."

Every document cited herein, including any cross referenced or related patent or application and any patent application or patent to which this application claims priority or benefit thereof, is hereby incorporated herein by reference in its entirety unless expressly excluded or otherwise limited. The citation of any document is not an admission that it is prior art with respect to any invention disclosed or claimed herein or that it alone, or in any combination with any other reference or references, teaches, suggests or discloses any such invention. Further, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition assigned to that term in this document shall govern.

While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.