Title:
FREE BASE CRYSTAL FORM OF POLYCYCLIC COMPOUND OF NITROGEN-CONTAINING HETEROCYCLE, AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2024/056016
Kind Code:
A1
Abstract:
The present invention relates to a free base crystal form of a polycyclic compound of a nitrogen-containing heterocycle, and a preparation method therefor. Specifically, the present invention provides a free base crystal form of a compound having general formula (I), a preparation method therefor, a pharmaceutical composition containing a therapeutically-effective amount of the crystal form, and a use thereof as an orexin receptor antagonist in the preparation of drugs for treating nervous system diseases.
Inventors:
YANG TONG (CN)
CHEN JINYAO (CN)
CHEN JINYAO (CN)
Application Number:
PCT/CN2023/118743
Publication Date:
March 21, 2024
Filing Date:
September 14, 2023
Export Citation:
Assignee:
JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
SHANGHAI HANSOH BIOMEDICAL CO LTD (CN)
International Classes:
C07D487/04; A61K31/407; A61P25/00
Domestic Patent References:
| WO2022194122A1 | 2022-09-22 | |||
| WO2020100011A1 | 2020-05-22 |
Foreign References:
| CN102781942A | 2012-11-14 | |||
| CN108299437A | 2018-07-20 | |||
| CN108883110A | 2018-11-23 | |||
| CN106749269A | 2017-05-31 | |||
| CN109988170A | 2019-07-09 |
Other References:
DEFLORIAN FRANCESCA, PEREZ-BENITO LAURA, LENSELINK EELKE B, CONGREVE MILES, VAN VLIJMEN HERMAN W. T., MASON JONATHAN S., GRAAF CHR: "Accurate Prediction of GPCR Ligand Binding Affinity with Free Energy Perturbation", JOURNAL OF CHEMICAL INFORMATION AND MODELING, AMERICAN CHEMICAL SOCIETY , WASHINGTON DC, US, vol. 60, no. 11, 23 November 2020 (2020-11-23), US , pages 5563 - 5579, XP055968396, ISSN: 1549-9596, DOI: 10.1021/acs.jcim.0c00449
SONGLIANG WU, YU SUN, YI HU, HONGMEI ZHANG, LIJUAN HOU, XING LIU, YUFENG LI, HAIYING HE, ZHI LUO, YUAN CHEN, YUHE WANG, WEIHUA SHI: "Discovery of novel substituted octahydropyrrolo[3,4- c ]pyrroles as dual orexin receptor antagonists for insomnia treatment", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 6, 1 March 2017 (2017-03-01), Amsterdam NL , pages 1458 - 1462, XP055493385, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.01.075
MICHAEL A. LETAVIC, PASCAL BONAVENTURE, NICHOLAS I. CARRUTHERS, CHRISTINE DUGOVIC, TATIANA KOUDRIAKOVA, BRIAN LORD, TIMOTHY W. LOV: "Novel Octahydropyrrolo[3,4- c ]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 14, 23 July 2015 (2015-07-23), US , pages 5620 - 5636, XP055493378, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b00742
SONGLIANG WU, YU SUN, YI HU, HONGMEI ZHANG, LIJUAN HOU, XING LIU, YUFENG LI, HAIYING HE, ZHI LUO, YUAN CHEN, YUHE WANG, WEIHUA SHI: "Discovery of novel substituted octahydropyrrolo[3,4- c ]pyrroles as dual orexin receptor antagonists for insomnia treatment", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 27, no. 6, 1 March 2017 (2017-03-01), Amsterdam NL , pages 1458 - 1462, XP055493385, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2017.01.075
MICHAEL A. LETAVIC, PASCAL BONAVENTURE, NICHOLAS I. CARRUTHERS, CHRISTINE DUGOVIC, TATIANA KOUDRIAKOVA, BRIAN LORD, TIMOTHY W. LOV: "Novel Octahydropyrrolo[3,4- c ]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 58, no. 14, 23 July 2015 (2015-07-23), US , pages 5620 - 5636, XP055493378, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.5b00742
Attorney, Agent or Firm:
GE CHENG & CO., LTD. (CN)
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