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Title:
FREE RADICAL CONSUMPTION SPEED INFORMATION ACQUISITION METHOD AND NASH DETERMINATION METHOD
Document Type and Number:
WIPO Patent Application WO/2017/217340
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for obtaining an index for non-invasively identifying NASH. Provided is a NASH determination method that includes a method for non-invasively detecting, in real time, a redox reaction in the liver of a test animal and acquiring information on free radical consumption speed, the NASH determination method including: a step (1) for obtaining free radical concentration data by applying a magnetic resonance method to the liver to be measured, after insertion of a probe into the body; a step (2) for obtaining imaging information by processing the obtained free radical concentration data; and a step (3) for kinematically measuring the imaging information over time and deriving the free radical consumption speed. The NASH determination method is characterized by including a step for determining whether the test animal has NASH, on the basis of the free radical consumption speed information obtained by applying the steps (1-3) to the test animal.

Inventors:
MURATA MASAHARU (JP)
HYODO FUMINORI (JP)
HASHIZUME MAKOTO (JP)
NAKATA RYOSUKE (JP)
AKAHOSHI TOMOHIKO (JP)
Application Number:
PCT/JP2017/021524
Publication Date:
December 21, 2017
Filing Date:
June 09, 2017
Export Citation:
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Assignee:
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
G01R33/48; A61B5/055; G01N24/12; G01N33/15; G01N33/50; G01R33/28
Domestic Patent References:
WO2014192894A12014-12-04
WO2011052760A12011-05-05
Foreign References:
JP2010022293A2010-02-04
JP2014055146A2014-03-27
Other References:
KEN'ICHI YAMADA ET AL.: "Seitainai Redox Hanno no Mushinshu Kaiseki o Mezashita Yugogata ESRI/MRI Sochi no Kaihatsu", THE 16TH SYMPOSIUM ON BIOMEDICAL-ANALYTICAL SCIENCES KOEN YOSHISHU, 2 August 2003 (2003-08-02), pages 112 - 113, XP 008160456
HIROHITO TSUBOUCHI: "Sanka Stress to NASH", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 206, 2 August 2003 (2003-08-02), pages 371 - 374, XP009511204
See also references of EP 3470867A4
Attorney, Agent or Firm:
KATO, Hisashi et al. (JP)
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