Title:
FREE RADICAL SCAVENGER CONTAINING SEMICARBAZIDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/093124
Kind Code:
A1
Abstract:
It is intended to provide a novel free radical scavenger for removing active oxygen which is causative for various diseases in vivo and results in degradation and color fade-out in commercial products. A free radical scavenger which contains a semicarbazide derivative represented by the following general formula (1) or its salt.
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Inventors:
OKAWARA TADASHI
IMAI KIMIE
OCHIAI TAKASHI
IMAI KIMIE
OCHIAI TAKASHI
Application Number:
PCT/JP2006/303703
Publication Date:
September 08, 2006
Filing Date:
February 28, 2006
Export Citation:
Assignee:
MANAC INC (JP)
Y NAT UNIVERSITY CORP KUMAMOTO
OKAWARA TADASHI
IMAI KIMIE
OCHIAI TAKASHI
Y NAT UNIVERSITY CORP KUMAMOTO
OKAWARA TADASHI
IMAI KIMIE
OCHIAI TAKASHI
International Classes:
A61K31/175; A23L1/30; A61K8/46; A61K31/381; A61K31/4409; A61K31/444; A61P39/06; C07C281/14; C07C337/08; C07D213/53; C07D333/20; C09K15/22
Domestic Patent References:
| WO2000038617A2 | 2000-07-06 |
Foreign References:
| JPH1059956A | 1998-03-03 | |||
| JP2003064359A | 2003-03-05 | |||
| US3734757A | 1973-05-22 | |||
| FR2058310A1 | 1971-05-28 |
Other References:
AGRAWAL K.C. ET AL.: "Potential Antitumor Agents. 14. 4-Substituted 2-Formylpyridine Thiosemicarbazones", JOURNAL OF MEDICINAL CHEMISTRY, vol. 19, no. 10, 1976, pages 1209 - 1214, XP002999169
DATABASE CAPLUS [online] SHABNAM A. ET AL.: "Synthesis of some thiocarbohydrazones and thiosemicarbazones as antibacterial and antitubercular agents", XP002999170, accession no. STN Database accession no. (1998:67895)
TOMCHIN A.B. ET AL.: "Semicarbazones and thiosemicarbazones of heterocyclic series. XXXVI. Antimycobacterial activity of hydrazones of alpha-dicarbonyl compounds", KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 10, no. 2, 1976, pages 45 - 48, XP002999171
HONG H. ET AL.: "Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 6, 1997, pages 930 - 936, XP002105987
CARLSON H.A. ET AL.: "Developing a Dynamic Pharmacophore Model for HIV-1 Integrase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 11, 2000, pages 2100 - 2114, XP002366667
DATABASE CAPLUS [online] ZABIN S.A. ET AL.: "Fluorescence, antibacterial and pigmentation studies of some binuclear Schiff base complexes", XP002999172, accession no. STN Database accession no. (1995:715840)
PATIL S.A. ET AL.: "COBALT(II) AND COPPER(II) COMPLEXES OF THIOCARBOHYDRAZONES AND COPPER(II) BIMETALLIC COMPLEXES OF NICKEL(II) THIOCARBOHYDRAZONES", ACTA CHIMICA HUNGARICA, vol. 118, no. 1, 1985, pages 3 - 10, XP002999173
DIMMOCK J.R. ET AL.: "Some aryl semicarbazones possessing anticonvulsant activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 4, 1995, pages 287 - 301, XP002014744
BACCHI A. ET AL.: "Antimicrobial and mutagenic activity of some carbono- and thiocarbonohydrazone ligands and their copper(II), iron(II) and zinc(II) complexes", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 75, no. 2, 1999, pages 123 - 133, XP002999174
WARAD D.U. ET AL.: "Synthesis, structure and reactivity of zirconium(IV), vanadium(IV), cobalt(II), nickel(II) and copper(II) complexes derived from carbohydrazide schiff base ligands", INDIAN JOURNAL OF CHEMISTRY, SECTION A (INORGANIC BIO-INORGANIC, PHYSICAL, THEORETICAL & ANALYTICAL CHEMISTRY), vol. 39A, no. 4, 2000, pages 415 - 420, XP002999175
DATABASE CAPLUS [online] SHABNAM A. ET AL.: "Synthesis of some thiocarbohydrazones and thiosemicarbazones as antibacterial and antitubercular agents", XP002999170, accession no. STN Database accession no. (1998:67895)
TOMCHIN A.B. ET AL.: "Semicarbazones and thiosemicarbazones of heterocyclic series. XXXVI. Antimycobacterial activity of hydrazones of alpha-dicarbonyl compounds", KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 10, no. 2, 1976, pages 45 - 48, XP002999171
HONG H. ET AL.: "Discovery of HIV-1 Integrase Inhibitors by Pharmacophore Searching", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 6, 1997, pages 930 - 936, XP002105987
CARLSON H.A. ET AL.: "Developing a Dynamic Pharmacophore Model for HIV-1 Integrase", JOURNAL OF MEDICINAL CHEMISTRY, vol. 43, no. 11, 2000, pages 2100 - 2114, XP002366667
DATABASE CAPLUS [online] ZABIN S.A. ET AL.: "Fluorescence, antibacterial and pigmentation studies of some binuclear Schiff base complexes", XP002999172, accession no. STN Database accession no. (1995:715840)
PATIL S.A. ET AL.: "COBALT(II) AND COPPER(II) COMPLEXES OF THIOCARBOHYDRAZONES AND COPPER(II) BIMETALLIC COMPLEXES OF NICKEL(II) THIOCARBOHYDRAZONES", ACTA CHIMICA HUNGARICA, vol. 118, no. 1, 1985, pages 3 - 10, XP002999173
DIMMOCK J.R. ET AL.: "Some aryl semicarbazones possessing anticonvulsant activities", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 30, no. 4, 1995, pages 287 - 301, XP002014744
BACCHI A. ET AL.: "Antimicrobial and mutagenic activity of some carbono- and thiocarbonohydrazone ligands and their copper(II), iron(II) and zinc(II) complexes", JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 75, no. 2, 1999, pages 123 - 133, XP002999174
WARAD D.U. ET AL.: "Synthesis, structure and reactivity of zirconium(IV), vanadium(IV), cobalt(II), nickel(II) and copper(II) complexes derived from carbohydrazide schiff base ligands", INDIAN JOURNAL OF CHEMISTRY, SECTION A (INORGANIC BIO-INORGANIC, PHYSICAL, THEORETICAL & ANALYTICAL CHEMISTRY), vol. 39A, no. 4, 2000, pages 415 - 420, XP002999175
Attorney, Agent or Firm:
Tsukuni, Hajime (22-12 Toranomon 1-chom, Minato-ku Tokyo 01, JP)
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